Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

(2014) Shereen Jamaladdin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function

(2013) M. R. Heideman et al.   BLOOD

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Transcription and beyond: the role of mammalian class I lysine deacetylases

(2013) Mirjam Andrea Moser et al.   CHROMOSOMA

Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis

(2013) Mircea Winter et al.   EMBO JOURNAL

Dynamic distribution of HDAC1 and HDAC2 during mitosis: Association with F-actin

(2013) Shihua He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

(2013) Zheng Sun et al.   MOLECULAR CELL

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression

(2013) Srividya Bhaskara et al.   Epigenetics & Chromatin

Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma

(2013) T. Clozel et al.   Cancer Discovery

Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives

(2012) Giuseppe Giannini et al.   Future Medicinal Chemistry

BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8

(2012) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC inhibitor-based therapies: Can we interpret the code?

(2012) Maria New et al.   Molecular Oncology

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes

(2012) Cedric R. Clapier et al.   NATURE

Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells

(2012) N Chapman-Rothe et al.   ONCOGENE

Role for histone deacetylase 3 in maintenance of genome stability

(2011) Srividya Bhaskara et al.   CELL CYCLE

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies

(2011) A. Petrella et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin

(2011) Jennifer K. Sims et al.   MOLECULAR BIOLOGY OF THE CELL

Histone Deacetylase Inhibitors: Emerging Mechanisms of Resistance

(2011) Robert W. Robey et al.   MOLECULAR PHARMACEUTICS

Relapsed/Refractory Diffuse Large B-Cell Lymphoma

(2011) J. W. Friedberg   Hematology-American Society of Hematology Education Program

Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

(2010) Srividya Bhaskara et al.   CANCER CELL

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

(2010) T. Yamaguchi et al.   GENES & DEVELOPMENT

Targeting histone deacetyalses in the treatment of B- and T-cell malignancies

(2010) Jasmine Zain et al.   INVESTIGATIONAL NEW DRUGS

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL

(2009) W. Ci et al.   BLOOD

Epigenetic control of skull morphogenesis by histone deacetylase 8

(2009) M. Haberland et al.   GENES & DEVELOPMENT

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Genetic dissection of histone deacetylase requirement in tumor cells

(2009) M. Haberland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

(2008) Stella M. Ranuncolo et al.   BLOOD CELLS MOLECULES AND DISEASES

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

(2008) Sarah K Knutson et al.   EMBO JOURNAL

Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion

(2008) G. Eot-Houllier et al.   GENES & DEVELOPMENT

BCL6-mediated Attenuation of DNA Damage Sensing Triggers Growth Arrest and Senescence through a p53-dependent Pathway in a Cell Context-dependent Manner

(2008) Stella Maris Ranuncolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

(2008) Srividya Bhaskara et al.   MOLECULAR CELL

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH