The mechanism of genome replication and transcription in bunyaviruses

Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription

(2022) Benoît Arragain et al.   Nature Communications

The C-terminal LCAR of host ANP32 proteins interacts with the influenza A virus nucleoprotein to promote the replication of the viral RNA genome

(2022) Fangzheng Wang et al.   NUCLEIC ACIDS RESEARCH

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals

(2022) Jingru Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture

(2022) Francis R. Hopkins et al.   mBio

Structural insights into RNA polymerases of negative-sense RNA viruses

(2021) Aartjan J. W. te Velthuis et al.   NATURE REVIEWS MICROBIOLOGY

Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus

(2021) Tim Krischuns et al.   Annual Review of Biochemistry

Reply to: Errors in the deposited SFTSV L protein structure

(2021) Panpan Wang et al.   Nature Microbiology

Errors in the deposited SFTSV L protein structure

(2021) Stephen Cusack et al.   Nature Microbiology

Isolation of reconstructed functional ribonucleoprotein complexes of Machupo virus

(2021) Jesse D. Pyle et al.   JOURNAL OF VIROLOGY

Structural basis for recognition and regulation of arenavirus polymerase L by Z protein

(2021) Huiling Kang et al.   Nature Communications

Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals

(2021) Xin Xu et al.   Nature Microbiology

The Host Factor ANP32A Is Required for Influenza A Virus vRNA and cRNA Synthesis

(2021) Benjamin E. Nilsson-Payant et al.   JOURNAL OF VIROLOGY

Structure of Rift Valley Fever Virus RNA-Dependent RNA Polymerase

(2021) Xue Wang et al.   JOURNAL OF VIROLOGY

Structure of Machupo virus polymerase in complex with matrix protein Z

(2021) Jun Ma et al.   Nature Communications

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

(2021) Tomas Kouba et al.   Nature Communications

The Cap-Snatching Mechanism of Bunyaviruses

(2020) Silke Olschewski et al.   TRENDS IN MICROBIOLOGY

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target

(2020) Wenjie Wang et al.   Cell Reports

A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase

(2020) Joanna M. Wandzik et al.   CELL

Mutation of an influenza virus polymerase 3′ RNA promoter binding site inhibits transcription elongation

(2020) Alexander P Walker et al.   JOURNAL OF VIROLOGY

Structural insight into arenavirus replication machinery

(2020) Ruchao Peng et al.   NATURE

Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein

(2020) Dominik Vogel et al.   NUCLEIC ACIDS RESEARCH

Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation

(2020) Panpan Wang et al.   Nature Microbiology

Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

(2020) Benoît Arragain et al.   Nature Communications

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Host ANP32A mediates the assembly of the influenza virus replicase

(2020) Loïc Carrique et al.   NATURE

High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

(2019) Benoît Arragain et al.   eLife

Biochemical characterization of the Lassa virus L protein

(2019) Dominik Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a functional cap-binding domain in Rift Valley fever virus L protein

(2019) Nadja Gogrefe et al.   PLoS Pathogens

Structural snapshots of actively transcribing influenza polymerase

(2019) Tomas Kouba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

(2019) Haitian Fan et al.   NATURE

Structure and function of the Toscana virus cap-snatching endonuclease

(2019) Rhian Jones et al.   NUCLEIC ACIDS RESEARCH

Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018

(2018) Piet Maes et al.   ARCHIVES OF VIROLOGY

Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses

(2018) Tobias Holm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses—The representatives of genus Hartmanivirus, family Arenaviridae

(2018) Jussi Hepojoki et al.   PLoS Pathogens

Toscana virus cap-snatching and initiation of transcription

(2017) Abdennour Amroun et al.   JOURNAL OF GENERAL VIROLOGY

A proteomic survey of Junín virus interactions with human proteins reveals host factors required for arenavirus replication

(2017) Christopher M. Ziegler et al.   JOURNAL OF VIROLOGY

Asymmetric Trimeric Ring Structure of the Nucleocapsid Protein of Tospovirus

(2017) Keisuke Komoda et al.   JOURNAL OF VIROLOGY

WHO R&D Blueprint: a global coordination mechanism for R&D preparedness

(2017) Marie Paule Kieny et al.   LANCET

Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

(2017) François Ferron et al.   VIRUS RESEARCH

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein

(2017) Kseniya Khamina et al.   PLoS Pathogens

Structural insights into reptarenavirus cap-snatching machinery

(2017) Maria Rosenthal et al.   PLoS Pathogens

Toscana virus nucleoprotein oligomer organization observed in solution

(2017) Amal Baklouti et al.   Acta Crystallographica Section D-Structural Biology

Activity inhibition and crystal polymorphism induced by active-site metal swapping

(2017) Elsie Yekwa et al.   Acta Crystallographica Section D-Structural Biology

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases

(2016) Juan Reguera et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

(2016) Eric Thierry et al.   MOLECULAR CELL

Structural basis of an essential interaction between influenza polymerase and Pol II CTD

(2016) Maria Lukarska et al.   NATURE

Making Bunyaviruses Talk: Interrogation Tactics to Identify Host Factors Required for Infection

(2016) Amber Riblett et al.   Viruses-Basel

Structure of the Hantavirus Nucleoprotein Provides Insights into the Mechanism of RNA Encapsidation

(2016) Daniel Olal et al.   Cell Reports

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases

(2016) Juan Reguera et al.   PLoS Pathogens

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein

(2016) Yaiza Fernández-García et al.   PLoS Pathogens

The role of the priming loop in influenza A virus RNA synthesis

(2016) Aartjan J. W. te Velthuis et al.   Nature Microbiology

Past, present, and future of arenavirus taxonomy

(2015) Sheli R. Radoshitzky et al.   ARCHIVES OF VIROLOGY

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

(2015) Piotr Gerlach et al.   CELL

Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation

(2015) Yu Guo et al.   JOURNAL OF VIROLOGY

Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins

(2015) Wenming Wang et al.   JOURNAL OF VIROLOGY

A Virus-Like Particle System Identifies the Endonuclease Domain of Crimean-Congo Hemorrhagic Fever Virus

(2015) Stephanie Devignot et al.   JOURNAL OF VIROLOGY

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

(2015) Narin Hengrung et al.   NATURE

The crystal structure of the Hazara virus nucleocapsid protein

(2015) Rebecca Surtees et al.   BMC STRUCTURAL BIOLOGY

Role of the C Terminus of Lassa Virus L Protein in Viral mRNA Synthesis

(2014) M. Lehmann et al.   JOURNAL OF VIROLOGY

Function and Control of RNA Polymerase II C-Terminal Domain Phosphorylation in Vertebrate Transcription and RNA Processing

(2014) J.-P. Hsin et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Orthobunyaviruses: recent genetic and structural insights

(2014) Richard M. Elliott   NATURE REVIEWS MICROBIOLOGY

Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein

(2014) Daniel Olal et al.   NUCLEIC ACIDS RESEARCH

High-Resolution Structure of the N-Terminal Endonuclease Domain of the Lassa Virus L Polymerase in Complex with Magnesium Ions

(2014) Gregor D. Wallat et al.   PLoS One

Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression

(2014) Brandyn R. West et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Incoming RNA Virus Nucleocapsids Containing a 5′-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling

(2013) Michaela Weber et al.   Cell Host & Microbe

Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression

(2013) Xue Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of Junin virus nucleoprotein

(2013) Y. Zhang et al.   JOURNAL OF GENERAL VIROLOGY

Characterization of messenger RNA termini in Schmallenberg virus and related Simbuviruses

(2013) D. Coupeau et al.   JOURNAL OF GENERAL VIROLOGY

The N Terminus of Andes Virus L Protein Suppresses mRNA and Protein Expression in Mammalian Cells

(2013) P. Heinemann et al.   JOURNAL OF VIROLOGY

Systems To Establish Bunyavirus Genome Replication in the Absence of Transcription

(2013) C. Klemm et al.   JOURNAL OF VIROLOGY

Structure of Schmallenberg Orthobunyavirus Nucleoprotein Suggests a Novel Mechanism of Genome Encapsidation

(2013) H. Dong et al.   JOURNAL OF VIROLOGY

Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential

(2013) L. Jiao et al.   JOURNAL OF VIROLOGY

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization

(2013) Antonio Ariza et al.   NUCLEIC ACIDS RESEARCH

Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation

(2013) F. Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein

(2013) J. Reguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation

(2013) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism

(2013) H. Dong et al.   RNA

Self-organization of the vesicular stomatitis virus nucleocapsid into a bullet shape

(2013) Ambroise Desfosses et al.   Nature Communications

The small genome segment of Bunyamwera orthobunyavirus harbours a single transcription-termination signal

(2012) G. Blakqori et al.   JOURNAL OF GENERAL VIROLOGY

Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage

(2012) Y. Wang et al.   JOURNAL OF VIROLOGY

Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease

(2012) Kathryn M. Hastie et al.   PLoS One

Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses

(2012) Y. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phleboviruses encapsidate their genomes by sequestering RNA bases

(2012) D. D. Raymond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of the Lassa Virus Nucleoprotein Revealed by X-ray Crystallography, Small-angle X-ray Scattering, and Electron Microscopy

(2011) Linda Brunotte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Wild-Type and Alternate Transcription Termination Signals in the Rift Valley Fever Virus Genome

(2011) E. Lara et al.   JOURNAL OF VIROLOGY

Conserved Residues in Lassa Fever Virus Z Protein Modulate Viral Infectivity at the Level of the Ribonucleoprotein

(2011) A. A. Capul et al.   JOURNAL OF VIROLOGY

Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression

(2011) K. M. Hastie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex

(2011) P. J. Kranzusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding

(2011) K. M. Hastie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cytoplasmic tail of hantavirus Gn glycoprotein interacts with RNA

(2011) Tomas Strandin et al.   VIROLOGY

The Pathogenesis of Rift Valley Fever

(2011) Tetsuro Ikegami et al.   Viruses-Basel

The Hexamer Structure of the Rift Valley Fever Virus Nucleoprotein Suggests a Mechanism for its Assembly into Ribonucleoprotein Complexes

(2011) François Ferron et al.   PLoS Pathogens

Short Double-stranded RNAs with an Overhanging 5′ ppp-Nucleotide, as Found in Arenavirus Genomes, Act as RIG-I Decoys

(2010) Jean-Baptiste Marq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unpaired 5′ ppp-Nucleotides, as Found in Arenavirus Double-stranded RNA Panhandles, Are Not Recognized by RIG-I

(2010) Jean-Baptiste Marq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How RNA viruses maintain their genome integrity

(2010) J. N. Barr et al.   JOURNAL OF GENERAL VIROLOGY

Amino acid changes within the Bunyamwera virus nucleocapsid protein differentially affect the mRNA transcription and RNA replication activities of assembled ribonucleoprotein templates

(2010) C. T. Walter et al.   JOURNAL OF GENERAL VIROLOGY

Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein

(2010) J. Hepojoki et al.   JOURNAL OF GENERAL VIROLOGY

Domain Structure of Lassa Virus L Protein

(2010) L. Brunotte et al.   JOURNAL OF VIROLOGY

Cap binding and immune evasion revealed by Lassa nucleoprotein structure

(2010) Xiaoxuan Qi et al.   NATURE

Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation

(2010) D. D. Raymond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly of a functional Machupo virus polymerase complex

(2010) P. J. Kranzusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bunyamwera virus can repair both insertions and deletions during RNA replication

(2010) C. T. Walter et al.   RNA

Interaction between hantaviral nucleocapsid protein and the cytoplasmic tail of surface glycoprotein Gn

(2010) Hao Wang et al.   VIRUS RESEARCH

Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

(2010) Juan Reguera et al.   PLoS Pathogens

The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

(2010) Benjamin Morin et al.   PLoS Pathogens

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

RNA-dependent RNA polymerases from flaviviruses and Picornaviridae

(2009) Julien Lescar et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Hantavirus Glycoprotein G1 Tail Contains Dual CCHC-type Classical Zinc Fingers

(2009) D. Fernando Estrada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An N-Terminal Region of Lassa Virus L Protein Plays a Critical Role in Transcription but Not Replication of the Virus Genome

(2009) M. Lelke et al.   JOURNAL OF VIROLOGY

Mapping of the Tacaribe Arenavirus Z-Protein Binding Sites on the L Protein Identified both Amino Acids within the Putative Polymerase Domain and a Region at the N Terminus of L That Are Critically Involved in Binding

(2008) M. Wilda et al.   JOURNAL OF VIROLOGY

Mutational Evidence for a Structural Model of the Lassa Virus RNA Polymerase Domain and Identification of Two Residues, Gly1394 and Asp1395, That Are Critical for Transcription but Not Replication of the Genome

(2008) M. Hass et al.   JOURNAL OF VIROLOGY

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY