Review
Microbiology
Robert F. Garry
Summary: Lassa virus is a locally endemic virus in West Africa that causes Lassa fever in humans through transmission from rodent reservoirs. Despite gaps in knowledge, efforts to develop countermeasures have increased due to frequent outbreaks and the potential risks posed by the virus.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Microbiology
Tierra K. Buck, Adrian S. Enriquez, Sharon L. Schendel, Michelle A. Zandonatti, Stephanie S. Harkins, Haoyang Li, Alex Moon-Walker, James E. Robinson, Luis M. Branco, Robert F. Garry, Erica Ollmann Saphire, Kathryn M. Hastie
Summary: Lassa virus is the causative agent of Lassa fever, with different lineages showing genetic diversity. Lineage I of LASV exhibits resistance to antibody neutralization due to single-amino-acid substitutions. The high genetic diversity of LASV may pose challenges in designing broadly reactive immunogens and therapeutics for all lineages.
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Virology
Yang Liu, Jiao Guo, Junyuan Cao, Guangshun Zhang, Xiaoying Jia, Peilin Wang, Gengfu Xiao, Wei Wang
Summary: The study identified casticin and bergamottin as potential candidate molecules for LASV therapy, with both compounds inhibiting LASV entry via different mechanisms and also showing inhibitory effects on authentic lymphocytic choriomeningitis virus. The conserved F446 in LASV GPC was found to play an important role in drug resistance in mammarenaviruses.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Yvon Deschambault, Geoff Soule, Levi Klassen, Angela Sloan, Jonathan Audet, Kim Azaransky, Abdulmajid S. Musa, Adama Ahmad, Afolabi M. Akinpelu, Nwando Mba, Derek R. Stein, Marc Ranson, Muhamad Almiski, Kevin Tierney, Gabor Fischer, Mable Chan, David Safronetz
Summary: Nigeria experiences annual outbreaks of Lassa fever, and recent outbreaks are often associated with clade II or clade III viruses. We developed and characterized a guinea pig adapted virus from a clade III LASV isolated in Nigeria in 2018, which caused lethal disease in Hartley guinea pigs. The adapted virus showed high virulence and exhibited hallmark symptoms of Lassa fever.
Article
Virology
Yuxia Hou, Yang Liu, Xiaoying Jia, Minmin Zhou, Wenting Mao, Siqi Dong, Yueli Zhang, Gengfu Xiao, Wei Wang
Summary: In this study, two compounds, F1920 and F1965, were identified as LASV entry inhibitors, providing a potential backbone for the development of lead drugs for preventing LASV infection.
Article
Biology
Danyil Grybchuk, Michaela Prochazkova, Tibor Fuzik, Aleksandras Konovalovas, Saulius Serva, Vyacheslav Yurchenko, Pavel Plevka
Summary: This study determined the structure and assembly mechanism of the L-BC virus using cryo-electron microscopy. The L-BC capsid has an icosahedral symmetry and the capsid proteins are stabilized by domain swapping. Additionally, some L-BC virus particles were found to be open and lacked one decamer of capsid proteins.
COMMUNICATIONS BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Rebekah Wood, Umaru Bangura, Joachim Marien, Moussa Douno, Elisabeth Fichet-Calvet
Summary: Lassa virus is the cause of Lassa Fever in humans, with the multimammate mouse as its main host. Human infections are assumed to come from contact with this animal or its excretions. Sampling feces in households from LASV-endemic regions in Guinea showed positive samples and sequencing confirmed the presence of LASV strains, suggesting feces sampling is a viable method for detection and sequencing.
Article
Chemistry, Analytical
Su-jin Hong, Eungyeong Park, Yoon-ha Jang, Ji-yeon Shim, Yeonju Park, Sila Jin, Shuang Guo, Yeon-ju Kim, Min-jeong Son, Lei Chen, Kwang-il Lim, Young Mee Jung
Summary: In this study, we utilized probe-free surface-enhanced Raman scattering (SERS) to identify multiple types of viruses by obtaining the spectral fingerprint of their surface proteins. Furthermore, the SERS-based method successfully distinguished influenza virus variants with surface protein mutations.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
David W. Redding, Rory Gibb, Chioma C. Dan-Nwafor, Elsie A. Ilori, Rimamdeyati Usman Yashe, Saliu H. Oladele, Michael O. Amedu, Akanimo Iniobong, Lauren A. Attfield, Christi A. Donnelly, Ibrahim Abubakar, Kate E. Jones, Chikwe Ihekweazu
Summary: Lassa Fever is a rodent-borne viral haemorrhagic fever that is a public health concern in West Africa. The disease occurrence and incidence is influenced by climate, poverty, agriculture and urbanisation factors, as well as reporting processes and diagnostic laboratory access. While including climatic variability improved retrospective prediction models, a climate-driven model performs similarly to baseline models for future predictions in 2020. Ongoing improvements in surveillance may lead to potential forecasting of Lassa Fever incidence for health planning.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Anise N. Happi, Testimony J. Olumade, Olusola A. Ogunsanya, Ayotunde E. Sijuwola, Seto C. Ogunleye, Judith U. Oguzie, Cecilia Nwofoke, Chinedu A. Ugwu, Samuel J. Okoro, Patricia I. Otuh, Louis N. Ngele, Oluwafemi O. Ojo, Ademola Adelabu, Roseline F. Adeleye, Nicholas E. Oyejide, Clinton S. Njaka, Jonathan L. Heeney, Christian T. Happi
Summary: In Lassa fever endemic areas of Nigeria, the prevalence of Lassa virus is high in different species of rodents, indicating complex transmission dynamics and increased environmental contact in reservoirs. This has direct implications for understanding the transmission risk, mitigation, and prevention of Lassa fever in humans.
MICROBIOLOGY SPECTRUM
(2022)
Review
Infectious Diseases
Vanessa Raabe, Aneesh K. Mehta, Jared D. Evans, Adam Beitscher, Nahid Bhadelia, David Brett-Major, Theodore J. Cieslak, Richard T. Davey, Jared D. Evans, Maria G. Frank, Peter Iwen, Mark G. Kortepeter, Corri Levine, Susan McLellan, Aneesh K. Mehta, Lauren Sauer, Erica S. Shenoy, Kimon Zachary
Summary: This article provides a concise overview of Lassa virus infection and Lassa fever disease from a clinical perspective. It summarizes the pathogenesis, clinical features, diagnostics, and potential therapies and vaccines for clinical or research use. The review highlights the current status of antiviral medications, vaccines, and treatment options, emphasizing the need for further research and clinical trials. This resource serves as a rapid reference for clinicians facing suspected infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Jose Villalain
Summary: Mammarenaviruses are important human pathogens worldwide, and this study discovers membrane-interacting protein domains through molecular dynamics simulations, providing guidance for finding antiviral molecules.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Multidisciplinary Sciences
Luigi Stagi, Martina Sini, Davide Carboni, Roberto Anedda, Giuliano Siligardi, Tiberiu-Marius Gianga, Rohanah Hussain, Plinio Innocenzi
Summary: Designing the architecture of l-lysine-based polymeric structures is a challenging task that requires control of the amino acid reactive groups. This study investigates the correlation between the protonation state of l-lysine and the hydrothermally grown structures. The results demonstrate that alkaline conditions promote branched structures, while high pH favors linear structures and acidic conditions trigger branching. This understanding opens the route to a refined design of polypeptide systems based on l-lysine.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Lifei Chen, Pu Chen, Shengping Li, Meiqin Jiang, Hong Zhang, Leiqing Chen, Xiaojing Huang, Yayu Chen, Lifang Sun, Panpan Dong, Pingdong Lin, Yunkun Wu
Summary: This study confirmed the interaction between rice stripe virus (RSV) specific protein (SP) and the host factor OsR3H3, and revealed the protein-binding mechanism of RSV SP through crystal structure analysis and mutagenesis experiments.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Infectious Diseases
Anke Thielebein, Yemisi Ighodalo, Abubakar Taju, Thomas Olokor, Racheal Omiunu, Rita Esumeh, Paulson Ebhodaghe, Anieno Ekanem, Ganiyu Igenegbale, Rosemary Giwa, Annick Renevey, Julia Hinzmann, Jonas Mueller, Elisa Pallasch, Meike Pahlmann, Jeremie Guedj, Joy Nwatuzor, Oluwasola Femi Babatunde, Donatus Adomeh, Danny Asogun, Nosa Akpede, Sylvanus Okogbenin, Stephan Guenther, Lisa Oestereich, Sophie Duraffour, Ephraim Ogbaini-Emovon
Summary: The study found that Lassa virus RNA can be detected in various body fluids after recovery from acute Lassa fever, with the longest persistence in seminal fluid. The results showed that the persistence of viral RNA in seminal fluid was associated with higher viral load, severity of disease, and longer hospitalization during the acute phase of Lassa fever.
Article
Infectious Diseases
Scarlett Sett, Carolina dos Santos Ribeiro, Christine Prat, George Haringhuizen, Amber Hartman Scholz
Summary: Biobanking infrastructures are crucial for early response to new viral outbreaks. The European Virus Archive played a key role in the global response to the COVID-19 pandemic, distributing viral resources for free and implementing benefit-sharing policies.
Article
Virology
Hugo Soubrier, Umaru Bangura, Chris Hoffmann, Ayodeji Olayemi, Adetunji Samuel Adesina, Stephan Guenther, Lisa Oestereich, Elisabeth Fichet-Calvet
Summary: This study evaluated the use of a capture enzyme-linked immunosorbent assay (ELISA) for detecting LASV-reactive IgG antibodies in Mastomys rodents. The ELISA showed a high accuracy of 97.1% in known exposure samples and exhibited strong agreement with an immunofluorescence assay (IFA). It can be used as an alternative to IFA for determining LASV IgG serostatus in Mastomys rodents.
Article
Immunology
Mirjam Groger, Peter Akhideno, Christine J. Kleist, Femi O. Babatunde, Osahogie Edeawe, Julia Hinzmann, ThankGod Akhigbe, Joy Nwatuzor, Gloria Eifediyi, Jonas Mueller, Mette Hinrichs, Meike Pahlmann, Francisca Naana Sarpong, Christine Wagner, Anke Thielebein, Louis Aihonwalan, Till Koch, Maria Riedner, Ephraim Ogbaini-Emovon, Sylvanus Okogbenin, Stephan Guenther, Sebastian G. Wicha, Michael Ramharter, Lisa Oestereich, Sophie Duraffour, Cyril Erameh
Summary: This study examines the pharmacokinetics of ribavirin in the treatment of Lassa fever and finds consistent exposure across patients. While ribavirin shows low antiviral efficacy, it may have anti-inflammatory effects. Further research is needed to determine the role of ribavirin in the treatment of Lassa fever.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Medicine, General & Internal
Fara R. Koundouno, Liana E. Kafetzopoulou, Martin Faye, Annick Renevey, Barre Soropogui, Kekoura Ifono, Emily V. Nelson, Aly A. Kamano, Charles Tolno, Giuditta Annibaldis, Saa L. Millimono, Jacob Camara, Karifa Kourouma, Ahmadou Dore, Tamba E. Millimouno, Fernand M. B. Tolno, Julia Hinzmann, Hugo Soubrier, Mette Hinrichs, Anke Thielebein, Glaucia Herzer, Meike Pahlmann, Georges A. Ki-Zerbo, Pierre Formenty, Anais Legand, Michael R. Wiley, Ousmane Faye, Moussa M. Diagne, Amadou A. Sall, Philippe Lemey, Aissatou Bah, Stephan Guenther, Sakoba Keita, Sophie Duraffour, N'Faly Magassouba
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jennifer Cable, Anthony Fauci, William E. Dowling, Stephan Guenther, Dennis A. Bente, Pragya Dhruv Yadav, Lawrence C. Madoff, Lin-Fa Wang, Rahul K. Arora, Maria Van Kerkhove, May C. Chu, Thomas Jaenisch, Jonathan H. Epstein, Simon David William Frost, Daniel G. Bausch, Lisa E. Hensley, Eric Bergeron, Ioannis Sitaras, Michael D. Gunn, Thomas W. Geisbert, Cesar Munoz-Fontela, Florian Krammer, Emmie de Wit, Pontus Nordenfelt, Erica Ollmann Saphire, Sarah C. Gilbert, Kizzmekia S. Corbett, Luis M. Branco, Sylvain Baize, Neeltje van Doremalen, Marco A. Krieger, Sue Ann Costa Clemens, Renske Hesselink, Dan Hartman
Summary: The importance of maintaining and strengthening investments in infrastructure, collaborations, laboratory and manufacturing capacity, diagnostics, etc. during the COVID-19 pandemic to enable quick, concerted responses to future threats, especially to zoonotic pathogens, was emphasized during a symposium gathering researchers from various sectors.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Virology
Monika Rottstegge, Tom Tipton, Lisa Oestereich, Paula Ruibal, Emily Nelson, Catherine Olal, Julia R. Port, Johan Seibel, Elisa Pallasch, Sabrina Bockholt, Fara Raymond Koundouno, Joseph Akoi Bore, Estefania Rodriguez, Beatriz Escudero-Perez, Stephan Guenther, Miles W. Carroll, Cesar Munoz-Fontela
Summary: Ebola virus disease (EVD) is a complex infectious disease characterized by high inflammation, multiorgan failure, dysregulation of immune responses, and coagulation abnormalities. The interaction between T cells and antigen-presenting cells (APC) plays a crucial role in the pathogenesis of EVD. Transplantation of T cells and APCs from survivors can protect against EVD in a mouse avatar model.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Nele Marie Brinkmann, Chris Hoffmann, Stephanie Wurr, Elisa Pallasch, Julia Hinzmann, Eleonore Ostermann, Wolfram Brune, Maria Elisabeth Eskes, Lukas Jungblut, Stephan Guenther, Ludmilla Unrau, Lisa Oestereich
Summary: The study suggests that the type I interferon response is not a major factor in the virus-host barrier for arenaviruses in Mastomys natalensis cells.
Article
Microbiology
Robert W. Cross, Ira M. Longini, Stephan Becker, Karin Bok, David Boucher, Miles W. Carroll, Janet Diaz, William E. Dowling, Ruxandra Draghia-Akli, James T. Duworko, John M. Dye, Michael A. Egan, Patricia Fast, Amy Finan, Courtney Finch, Thomas R. Fleming, Joan Fusco, Thomas W. Geisbert, Anthony Griffiths, Stephan Guenther, Lisa E. Hensley, Anna Honko, Ruth Hunegnaw, Jocelyn Jakubik, Julie Ledgerwood, Kerstin Luhn, Demetrius Matassov, Jeffrey Meshulam, Emily Nelson, Christopher L. Parks, Roxana Rustomjee, David Safronetz, Lauren M. Schwartz, Dean Smith, Paul Smock, Ydrissa Sow, Christina F. Spiropoulou, Nancy J. Sullivan, Kelly L. Warfield, Daniel Wolfe, Courtney Woolsey, Roland Zahn, Ana Maria Henao-Restrepo, Cesar Munoz-Fontela, Andrea Marzi
Summary: This article discusses the current progress, challenges, and future directions of MARV vaccines, as well as the formation of the MARVAC consortium to respond to the threat of this infectious disease.
Article
Virology
Jens H. Kuhn, Scott Adkins, Sergey Alkhovsky, Tatjana Avsic-Zupanc, Maria A. Ayllon, Justin Bahl, Anne Balkema-Buschmann, Matthew J. Ballinger, Martina Bandte, Martin Beer, Nicolas Bejerman, Eric Bergeron, Nadine Biedenkopf, Laurent Bigarre, Carol D. Blair, Kim R. Blasdell, Steven B. Bradfute, Thomas Briese, Paul A. Brown, Remy Bruggmann, Ursula J. Buchholz, Michael J. Buchmeier, Alexander Bukreyev, Felicity Burt, Carmen Buettner, Charles H. Calisher, Thierry Candresse, Jeremy Carson, Inmaculada Casas, Kartik Chandran, Remi N. Charrel, Yuya Chiaki, Anya Crane, Mark Crane, Laurent Dacheux, Elena Dal Bo, Juan Carlos de la Torre, Xavier de Lamballerie, William M. de Souza, Rik L. de Swart, Nolwenn M. Dheilly, Nicholas Di Paola, Francesco Di Serio, Ralf G. Dietzgen, Michele Digiaro, J. Felix Drexler, W. Paul Duprex, Ralf Duerrwald, Andrew J. Easton, Toufc Elbeaino, Koray Ergunay, Guozhong Feng, Claudette Feuvrier, Andrew E. Firth, Anthony R. Fooks, Pierre B. H. Formenty, Juliana Freitas-Astua, Selma Gago-Zachert, Maria Laura Garcia, Adolfo Garcia-Sastre, Aura R. Garrison, Scott E. Godwin, Jean-Paul J. Gonzalez, Joelle Gouy de Bellocq, Anthony Grifths, Martin H. Groschup, Stephan Gunther, John Hammond, Jussi Hepojoki, Melanie M. Hierweger, Seiji Hongo, Masayuki Horie, Hidenori Horikawa, Holly R. Hughes, Adam J. Hume, Timothy H. Hyndman, Daohong Jiang, Gilda B. Jonson, Sandra Junglen, Fujio Kadono, David G. Karlin, Boris Klempa, Jonas Klingstrom, Michel C. Koch, Hideki Kondo, Eugene Koonin, Jarmila Krasova, Mart Krupovic, Kenji Kubota, Ivan Kuzmin, Lies Laenen, Amy J. Lambert, Jianrong Li, Jun-Min Li, Francois Liefrig, Igor S. Lukashevich, Dongsheng Luo, Piet Maes, Marco Marklewitz, Sergio H. Marshall, Shin-Yi L. Marzano, John W. McCauley, Ali Mirazimi, Peter G. Mohr, Nick J. G. Moody, Yasuaki Morita, Richard N. Morrison, Elke Muhlberger, Rayapati Naidu, Tomohide Natsuaki, Jose A. Navarro, Yutaro Neriya, Sergey Netesov, Gabriele Neumann, Norbert Nowotny, Francisco M. Ochoa-Corona, Gustavo Palacios, Laurane Pallandre, Vicente Pallas, Anna Papa, Sofa Paraskevopoulou, Colin R. Parrish, Alex Pauvolid-Correa, Janusz T. Paweska, Daniel R. Perez, Florian Pfaf, Richard K. Plemper, Thomas S. Postler, Francoise Pozet, Sheli R. Radoshitzky, Pedro L. Ramos-Gonzalez, Marius Rehanek, Renato O. Resende, Carina A. Reyes, Victor Romanowski, Dennis Rubbenstroth, Luisa Rubino, Artemis Rumbou, Jonathan A. Runstadler, Melanie Rupp, Sead Sabanadzovic, Takahide Sasaya, Heike Schmidt-Posthaus, Martin Schwemmle, Torsten Seuberlich, Stephen R. Sharpe, Mang Shi, Manuela Sironi, Sophie Smither, Jin-Won Song, Kirsten M. Spann, Jessica R. Spengler, Mark D. Stenglein, Ayato Takada, Robert B. Tesh, Jana Tesikova, Natalie J. Thornburg, Nicole D. Tischler, Yasuhiro Tomitaka, Keizo Tomonaga, Noel Tordo, Kenta Tsunekawa, Massimo Turina, Ioannis E. Tzanetakis, Anna Maria Vaira, Bernadette van den Hoogen, Bert Vanmechelen, Nikos Vasilakis, Martin Verbeek, Susanne von Bargen, Jiro Wada, Victoria Wahl, Peter J. Walker, Anna E. Whitfeld, John Williams, Yuri Wolf, Junki Yamasaki, Hironobu Yanagisawa, Gongyin Ye, Yong-Zhen Zhang, Arnfnn Lodden Okland
Summary: This article presents the updated taxonomy of Negarnaviricota, including the addition of new families, genera, and species, renaming and moving of species, and correction of misspelled names as accepted by the International Committee on Taxonomy of Viruses (ICTV).
ARCHIVES OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Suzanne N. Penfold, Ayola Akim A. Adegnika, Danny F. Asogun, Olufemi Ayodeji, Benedict Azuogu, William A. Fischer, Robert Garry, Donald Samuel Grant, Christian Happi, Magassouba A. N'Faly, Adebola Olayinka, Robert Samuels, Jefferson Sibley, David Wohl, Manfred Accrombessi, Ifedayo Adetifa, Giuditta Annibaldis, Anton Camacho, Chioma Dan-Nwafor, Akpene Ruth Esperencia Deha, Jean DeMarco, Sophie Duraffour, Augustine Goba, Rebecca Grais, Stephan Guenther, Enagnon Junior Juvenal Prince Honvou, Chikwe Ihekweazu, Christine Jacobsen, Lansana Kanneh, Mambu Momoh, Aminata Ndiaye, Robert Nsaibirni, Sylvanus Okogbenin, Chinwe S. Ochu, Ephraim Ogbaini, Enagnon Parsifal Marie Alexandre Logbo, John Demby Sandi, John Schieffelin, Thomas Verstraeten, Nathalie Vielle, Anges Yadouleton, Emmanuel Koffi Yovo
Summary: Lassa fever, caused by Lassa fever virus (LASV), is endemic in West Africa and causes 5000 fatalities each year. The aim of the Enable Lassa research programme is to estimate the incidences of LASV infection and LF disease in five West African countries. The core protocol harmonises key study components to ensure data comparability for between-country analyses.
Article
Infectious Diseases
Nzelle Delphine Kayem, Sylvanus Okogbenin, Joseph Okoeguale, Joseph Eigbefoh, Joseph Ikheloa, Reuben Eifediyi, Xavier Enodiana, Olugbenga Emmanuel Olorogbogo, Isoken Aikpokpo, Yemisi Ighodalo, Thomas Olokor, George Odigie, Lyndsey Castle, Sophie Duraffour, Lisa Oestereich, Prabin Dahal, Proochista Ariana, Stephan Gunther, Peter Horby
Summary: This study aims to evaluate the efficiency of transplacental transfer of Lassa virus antibodies from mother to child. The study demonstrates that maternal antibody levels play a crucial role in determining the transfer efficiency and may be influenced by the timing of antibody development. The study suggests that vaccination before pregnancy, in women of childbearing age, may be more appropriate for protecting both pregnant women and their neonates.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Nzelle Delphine Kayem, Sylvanus Okogbenin, Joseph Okoeguale, Mojeed Momoh, Antonia Njoku, Reuben Eifediyi, Xavier Enodiana, Hilary Ngwu, Wilfred Irhiogbe, Yemisi Ighodalo, Thomas Olokor, George Odigie, Lyndsey Castle, Sophie Duraffour, Lisa Oestereich, Prabin Dahal, Proochista Ariana, Stephan Gunther, Peter Horby
Summary: This study evaluated the epidemiology of Lassa fever in pregnant women in South Nigeria and found that about 50% of pregnant women had Lassa virus antibodies, indicating a high risk of Lassa infection during pregnancy. It also suggested that 35.0% of infections could be prevented by avoiding rodent exposure and conditions that facilitate infestation. Public health measures such as improved sanitation and hygiene could be beneficial in reducing the risk of infection.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Immunology
Stephanie Longet, Cristina Leggio, Joseph Akoi Bore, Stephanie Key, Tom Tipton, Yper Hall, Fara Raymond Koundouno, Hilary Bower, Tapan Bhattacharyya, N'Faly Magassouba, Stephan Guenther, Ana-Maria Henao-Restrapo, Jeremy S. Rossman, Mandy Kader Konde, Kimberly Fornace, Miles W. Carroll
Summary: The exposure to Lassa fever virus (LASV) showed heterogeneity in different ecological regions of Guinea, with seropositivity rates of 11.9% in coastal areas and 59.6% in forested areas. There were significant associations between LASV exposure risk and landscape fragmentation in coastal and forested regions. This study highlights the potential link between environmental change and LASV emergence, emphasizing the urgent need for research on land management practices that reduce disease risks.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Sylvanus Okogbenin, Cyril Erameh, Joseph Okoeguale, Osahogie Edeawe, Esele Ekuaze, Kelly Iraoyah, John Agho, Mirjam Groger, Benno Kreuels, Lisa Oestereich, Femi O. Babatunde, Peter Akhideno, Stephan Gunther, Michael Ramharter, Till Omansen
Summary: This study reported successful remission of complicated Lassa fever in two patients in Nigeria, who received the anti-inflammatory agent dexamethasone and standard ribavirin treatment.
EMERGING INFECTIOUS DISEASES
(2022)