Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development

(2015) Murli Mishra et al.   CANCER LETTERS

Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties

(2015) Jan Olof G. Karlsson et al.   DRUG DISCOVERY TODAY

Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer

(2015) C.-Y. Cai et al.   EJSO

Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: A novel synergistic therapeutic approach

(2015) Michelle Kiebala et al.   EXPERIMENTAL HEMATOLOGY

Phase 1/2 Trials of Temozolomide, Motexafin Gadolinium, and 60-Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme: Final Results of RTOG 0513

(2015) David G. Brachman et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells

(2015) Marijke C.C. Sachweh et al.   Oncotarget

De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells

(2015) Yan-hua Ren et al.   Oncotarget

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells

(2014) Francesco Vieceli Dalla Sega et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Thioredoxin 1 as a serum marker for ovarian cancer and its use in combination with CA125 for improving the sensitivity of ovarian cancer diagnoses

(2014) Byung-Joon Park et al.   BIOMARKERS

Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma

(2014) P. M. Barr et al.   BLOOD

The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs

(2014) Shifu Tang et al.   CANCER LETTERS

Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer

(2014) Joanne Collazo et al.   CANCER RESEARCH

Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis

(2014) L. Wu et al.   CARCINOGENESIS

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

The extraordinary catalytic ability of peroxiredoxins: a combined experimental and QM/MM study on the fast thiol oxidation step

(2014) Ari Zeida et al.   CHEMICAL COMMUNICATIONS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

PRDX6 promotes lung tumor progression via its GPx and iPLA2 activities

(2014) Hyung-Mun Yun et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMPK: A cellular metabolic and redox sensor. A minireview

(2014) Najeeb Shirwany   Frontiers in Bioscience-Landmark

Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration

(2014) Yvonne Samstag et al.   IMMUNOLOGICAL REVIEWS

Nitration Transforms a Sensitive Peroxiredoxin 2 into a More Active and Robust Peroxidase

(2014) Lía M. Randall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

(2014) Xinlai Cheng et al.   Molecular Cancer

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer

(2014) Jennifer A Morrison et al.   Molecular Cancer

Novel Roles for ERK5 and Cofilin as Critical Mediators Linking ERα-Driven Transcription, Actin Reorganization, and Invasiveness in Breast Cancer

(2014) Zeynep Madak-Erdogan et al.   MOLECULAR CANCER RESEARCH

Unknown

(2014) Daniel Antoine et al.   MOLECULAR MEDICINE

Unknown

(2014) Melinda Magna et al.   MOLECULAR MEDICINE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal

(2014) S. Salzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors

(2014) S Mohanty et al.   Cell Death & Disease

Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo

(2014) C Fan et al.   Cell Death & Disease

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases

(2014) Eiji Yoshihara et al.   Frontiers in Immunology

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Tyrosine Kinase Signal Modulation: A Matter of H2O2 Membrane Permeability?

(2013) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-Interacting Protein Expression Is Required for VEGF-Mediated Angiogenic Signal in Endothelial Cells

(2013) Mohammed A. Abdelsaid et al.   ANTIOXIDANTS & REDOX SIGNALING

Inflammation, DAMPs, Tumor Development, and Progression: A Vicious Circle Orchestrated by Redox Signaling

(2013) Patrizia Castellani et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species at phospholipid bilayers: Distribution, mobility and permeation

(2013) Rodrigo M. Cordeiro   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

(2013) J. Han et al.   BLOOD

Does phosphorylation of cofilin affect the progression of human bladder cancer?

(2013) Hong Chung et al.   BMC CANCER

AMP-activated protein kinase (AMPK) beyond metabolism

(2013) Toran Sanli et al.   CANCER BIOLOGY & THERAPY

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

Lung tumor growth-promoting function of peroxiredoxin 6

(2013) Miran Jo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oncogenic functions of the transcription factor Nrf2

(2013) Irene Gañán-Gómez et al.   FREE RADICAL BIOLOGY AND MEDICINE

The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer

(2013) Kerrilyn R Diener et al.   IMMUNOLOGY AND CELL BIOLOGY

Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α

(2013) Xiangjun Ji et al.   INTERNATIONAL JOURNAL OF CANCER

Nrf2 expression participates in growth and differentiation of endometrial carcinoma cells in vitro and in vivo

(2013) Kainan Li et al.   JOURNAL OF MOLECULAR HISTOLOGY

Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma

(2013) Qi-Kai Sun et al.   MEDICAL ONCOLOGY

Gossypol induces apoptosis in ovarian cancer cells through oxidative stress

(2013) Jia Wang et al.   Molecular BioSystems

Redox-Dependent Control of FOXO/DAF-16 by Transportin-1

(2013) Marrit Putker et al.   MOLECULAR CELL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma

(2013) Y. Soini et al.   PATHOLOGY RESEARCH AND PRACTICE

Ménage à Trois in stress: DAMPs, redox and autophagy

(2013) Guanqiao Li et al.   SEMINARS IN CANCER BIOLOGY

Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid

(2013) Qingfeng Tang et al.   TUMOR BIOLOGY

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress

(2012) Ying Wang et al.   ACTA PHARMACOLOGICA SINICA

Protein-Thiol Oxidation and Cell Death: Regulatory Role of Glutaredoxins

(2012) Erin M.G. Allen et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin System in Cell Death Progression

(2012) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

(2012) Dler Faieeq Darweesh Mahmood et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

(2012) Samuel Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-Interacting Protein Mediates Nuclear–to–Plasma Membrane Communication

(2012) Oded N. Spindel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways

(2012) Suboj Babykutty et al.   CLINICAL & EXPERIMENTAL METASTASIS

Chemistry and Pharmacology of Imexon and Related Cyanoaziridines

(2012) W.A. Remers et al.   CURRENT MEDICINAL CHEMISTRY

Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells

(2012) Pradeep Kumar Sharma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression

(2012) Woojin Jeong et al.   FREE RADICAL BIOLOGY AND MEDICINE

DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway

(2012) Joo-Young Im et al.   HUMAN MOLECULAR GENETICS

Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish

(2012) Sa Kan Yoo et al.   JOURNAL OF CELL BIOLOGY

Cyclic GMP/protein kinase G type-Iα (PKG-Iα) signaling pathway promotes CREB phosphorylation and maintains higher c-IAP1, livin, survivin, and Mcl-1 expression and the inhibition of PKG-Iα kinase activity synergizes with cisplatin in non-small cell lung c

(2012) Janica C. Wong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disulfide Biochemistry in 2-Cys Peroxiredoxin: Requirement of Glu50 and Arg146 for the Reduction of Yeast Tsa1 by Thioredoxin

(2012) Carlos A. Tairum et al.   JOURNAL OF MOLECULAR BIOLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

(2012) Yuji Okuno et al.   NATURE MEDICINE

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

(2012) Arya Sobhakumari et al.   PLoS One

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes

(2012) Deepak Jain et al.   Journal of Molecular Cell Biology

Activation of antioxidant response element (ARE)-dependent genes by roasted coffee extracts

(2012) Liu Yazheng et al.   Food & Function

The Cystine/Cysteine Cycle and GSH Are Independent and Crucial Antioxidant Systems in Malignant Melanoma Cells and Represent Druggable Targets

(2011) Roberta Venè et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Sensing by Proteins: Oxidative Modifications on Cysteines and the Consequent Events

(2011) Ying Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-interacting protein suppresses bladder carcinogenesis

(2011) Koji Nishizawa et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Factors Affecting Protein Thiol Reactivity and Specificity in Peroxide Reduction

(2011) Gerardo Ferrer-Sueta et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines

(2011) Faranak Fallahian et al.   FEBS Journal

Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis

(2011) Nihal Kaplan et al.   FREE RADICAL RESEARCH

Cellular Iron Depletion Stimulates the JNK and p38 MAPK Signaling Transduction Pathways, Dissociation of ASK1-Thioredoxin, and Activation of ASK1

(2011) Yu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi FujiiThioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus

(2011) Hiroshi Masutani et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Peroxiredoxin II Is an Essential Antioxidant Enzyme that Prevents the Oxidative Inactivation of VEGF Receptor-2 in Vascular Endothelial Cells

(2011) Dong Hoon Kang et al.   MOLECULAR CELL

The effects of acrolein on the thioredoxin system: Implications for redox-sensitive signaling

(2011) Charles R. Myers et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling

(2011) Q. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism

(2011) A. Kruger et al.   Science Signaling

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

(2011) Scott Ditch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer

(2011) Young Sun Kim et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure-based Insights into the Catalytic Power and Conformational Dexterity of Peroxiredoxins

(2010) Andrea Hall et al.   ANTIOXIDANTS & REDOX SIGNALING

Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products

(2010) Michael Haack et al.   BIOLOGICAL CHEMISTRY

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Prioritization of Competing Damage and Developmental Signals by Migrating Macrophages in the Drosophila Embryo

(2010) Severina Moreira et al.   CURRENT BIOLOGY

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

(2010) Shan Yan et al.   EMBO JOURNAL

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Selective Anticancer Activity of Organochalcogen Based Redox Catalysts

(2010) Mandy Doering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces

(2010) Stefano M. Marino et al.   JOURNAL OF MOLECULAR BIOLOGY

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

Extracellular SOD-Derived H2O2 Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

(2010) Jin Oshikawa et al.   PLoS One

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

(2010) E. W. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells

(2010) G H Wabnitz et al.   Cell Death & Disease

Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

(2010) Yi Feng et al.   PLOS BIOLOGY

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Reactive oxygen species-dependent signaling regulates cancer

(2009) Frank Weinberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas

(2009) Vikas Anathy et al.   JOURNAL OF CELL BIOLOGY

c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: phosphorylation of cJun, JunB, and Fra-1

(2009) Kumuda C. Das et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway

(2009) Jun-Sub Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin

(2009) Fábio Klamt et al.   NATURE CELL BIOLOGY

Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

(2009) Tobias B Dansen et al.   Nature Chemical Biology

The cunning little vixen: Foxo and the cycle of life and death

(2009) Stephen M Hedrick   NATURE IMMUNOLOGY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer

(2009) M. Sheffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Induction of Sulfiredoxin via an Nrf2-Dependent Pathway and Hyperoxidation of Peroxiredoxin III in the Lungs of Mice Exposed to Hyperoxia

(2008) Soo Han Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Signaling Across Cell Membranes

(2008) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis

(2008) In-Kiu Kwon et al.   CANCER

Reactive oxygen species in tumor metastasis

(2008) Makiya Nishikawa   CANCER LETTERS

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

(2008) Anju Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element

(2008) Ibrul Chowdhury et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

Oxidation of Cofilin Mediates T Cell Hyporesponsiveness under Oxidative Stress Conditions

(2008) Martin Klemke et al.   IMMUNITY

Evidence for the Formation of a Covalent Thiosulfinate Intermediate with Peroxiredoxin in the Catalytic Mechanism of Sulfiredoxin

(2008) Xavier Roussel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione

(2008) Francesc X. Soriano et al.   JOURNAL OF NEUROCHEMISTRY

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA