CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

(2022) Sneha Munshi et al.   Viruses-Basel

Evaluating ribosomal frameshifting in CCR5 mRNA decoding

(2022) Yousuf A. Khan et al.   NATURE

False-positive IRESes from Hoxa9 and other genes resulting from errors in mammalian 5′ UTR annotations

(2022) Christina Akirtava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

(2021) Mathias Girbig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

(2021) Pramod R. Bhatt et al.   SCIENCE

Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

(2021) Kaiming Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting

(2021) Yu Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling

(2021) David J. Young et al.   Nature Communications

Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis

(2020) Casey E. Hughes et al.   CELL

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

(2020) Ross A. Weber et al.   MOLECULAR CELL

Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)

(2020) Jamie A. Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3ʹ UTR-Directed Regulation and Nonsense-Mediated Decay

(2020) Xiaoqiang Zhu et al.   Cell Reports

The coding capacity of SARS-CoV-2

(2020) Yaara Finkel et al.   NATURE

DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

(2020) Jonathan Bohlen et al.   Nature Communications

Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

(2020) Hafeez S. Haniff et al.   ACS Central Science

Structure of human RNA polymerase III

(2020) Ewan Phillip Ramsay et al.   Nature Communications

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance

(2019) Natalia Korniy et al.   NUCLEIC ACIDS RESEARCH

Translational recoding: canonical translation mechanisms reinterpreted

(2019) Marina V Rodnina et al.   NUCLEIC ACIDS RESEARCH

Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection

(2019) Hema Manjunath et al.   Cell Reports

Broad range of missense error frequencies in cellular proteins

(2018) Raffaella Garofalo et al.   NUCLEIC ACIDS RESEARCH

Widespread Accumulation of Ribosome-Associated Isolated 3′ UTRs in Neuronal Cell Populations of the Aging Brain

(2018) Peter H. Sudmant et al.   Cell Reports

Non-AUG translation: a new start for protein synthesis in eukaryotes

(2017) Michael G. Kearse et al.   GENES & DEVELOPMENT

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

(2017) Ryan J. Golden et al.   NATURE

Avoidance of reporter assay distortions from fused dual reporters

(2017) Gary Loughran et al.   RNA

Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1

(2017) Ivan B. Lomakin et al.   Cell Reports

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

(2016) Nerea Irigoyen et al.   PLoS Pathogens

The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion

(2015) Viktoria Désirée Paul et al.   eLife

DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

(2014) Sibylle Schleich et al.   NATURE

Reselection of a Genomic Upstream Open Reading Frame in Mouse Hepatitis Coronavirus 5'-Untranslated-Region Mutants

(2013) H.-Y. Wu et al.   JOURNAL OF VIROLOGY

Reinitiation and Other Unconventional Posttermination Events during Eukaryotic Translation

(2013) Maxim A. Skabkin et al.   MOLECULAR CELL

Studies of translational misreading in vivo show that the ribosome very efficiently discriminates against most potential errors

(2013) N. Manickam et al.   RNA

Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production

(2013) Ewan Plant et al.   Viruses-Basel

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species

(2012) Alawiah Alhebshi et al.   MOLECULAR BIOLOGY OF THE CELL

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

(2012) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of RNA Pseudoknot-Binding Ligand That Inhibits the −1 Ribosomal Frameshifting of SARS-Coronavirus by Structure-Based Virtual Screening

(2011) So-Jung Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transcription by RNA polymerase III: more complex than we thought

(2011) Robert J. White   NATURE REVIEWS GENETICS

Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

(2010) M. A. Skabkin et al.   GENES & DEVELOPMENT

A comprehensive analysis of translational missense errors in the yeast Saccharomyces cerevisiae

(2010) E. B. Kramer et al.   RNA

NS1' of Flaviviruses in the Japanese Encephalitis Virus Serogroup Is a Product of Ribosomal Frameshifting and Plays a Role in Viral Neuroinvasiveness

(2009) E. B. Melian et al.   JOURNAL OF VIROLOGY