Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

Conformational Shannon Entropy of mRNA Structures from Force Spectroscopy Measurements Predicts the Efficiency of −1 Programmed Ribosomal Frameshift Stimulation

(2021) Matthew T. J. Halma et al.   PHYSICAL REVIEW LETTERS

Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers

(2021) Sara Ibrahim Omar et al.   PLoS Computational Biology

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

(2021) Pramod R. Bhatt et al.   SCIENCE

Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

(2021) Kaiming Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting

(2021) Yu Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses

(2021) Dae-Gyun Ahn et al.   Viruses-Basel

Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers

(2021) Krishna Neupane et al.   Nature Communications

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

(2020) Markus Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Forty years with coronaviruses

(2020) Susan R. Weiss   JOURNAL OF EXPERIMENTAL MEDICINE

RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look

(2020) Ramya Rangan et al.   RNA

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

(2020) Chen Bao et al.   eLife

Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)

(2020) Jamie A. Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner

(2020) Mizuki Yamamoto et al.   Viruses-Basel

Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot

(2020) Krishna Neupane et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

(2020) Hafeez S. Haniff et al.   ACS Central Science

Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences

(2020) C. Louwrens Braal et al.   DRUGS

Programmed −1 Ribosomal Frameshifting in coronaviruses: A therapeutic target

(2020) Jamie A. Kelly et al.   VIROLOGY

Bats and Coronaviruses

(2019) Arinjay Banerjee et al.   Viruses-Basel

CDK4/6 Inhibitors Expand the Therapeutic Options in Breast Cancer: Palbociclib, Ribociclib and Abemaciclib

(2019) Tanja K. Eggersmann et al.   BIODRUGS

Unveiling the druggable RNA targets and small molecule therapeutics

(2019) Joanna Sztuba-Solinska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Complex dynamics under tension in a high-efficiency frameshift stimulatory structure

(2019) Matthew T. J. Halma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

Conformational dynamics of the frameshift stimulatory structure in HIV-1

(2017) Dustin B. Ritchie et al.   RNA

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay

(2016) Mizuki Yamamoto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Amongcis-Acting RNA Elements

(2016) Christine Moomau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use

(2016) John F. Atkins et al.   NUCLEIC ACIDS RESEARCH

Virus Variation Resource – improved response to emergent viral outbreaks

(2016) Eneida L. Hatcher et al.   NUCLEIC ACIDS RESEARCH

Ribosome Excursions during mRNA Translocation Mediate Broad Branching of Frameshift Pathways

(2015) Shannon Yan et al.   CELL

Genomic discovery of potent chromatin insulators for human gene therapy

(2015) Mingdong Liu et al.   NATURE BIOTECHNOLOGY

A general strategy to inhibiting viral −1 frameshifting based on upstream attenuation duplex formation

(2015) Hao-Teng Hu et al.   NUCLEIC ACIDS RESEARCH

The RNA shapes studio

(2014) S. Janssen et al.   BIOINFORMATICS

Single-Molecule Measurements of the CCR5 mRNA Unfolding Pathways

(2014) Michel de Messieres et al.   BIOPHYSICAL JOURNAL

Programmed –1 Frameshifting by Kinetic Partitioning during Impeded Translocation

(2014) Neva Caliskan et al.   CELL

Anti-frameshifting Ligand Reduces the Conformational Plasticity of the SARS Virus Pseudoknot

(2014) Dustin B. Ritchie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic pathways of −1 translational frameshifting

(2014) Jin Chen et al.   NATURE

Ribosomes in the balance: structural equilibrium ensures translational fidelity and proper gene expression

(2014) Sharmishtha Musalgaonkar et al.   NUCLEIC ACIDS RESEARCH

Clustering by fast search and find of density peaks

(2014) A. Rodriguez et al.   SCIENCE

Direct measurement of the mechanical work during translocation by the ribosome

(2014) Tingting Liu et al.   eLife

Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production

(2013) Ewan Plant et al.   Viruses-Basel

Programmed -1 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding

(2012) D. B. Ritchie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and implications of programmed translational frameshifting

(2012) Jonathan D. Dinman   Wiley Interdisciplinary Reviews-RNA

Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication

(2011) Dae-Gyun Ahn et al.   ANTIVIRAL RESEARCH

Identification of RNA Pseudoknot-Binding Ligand That Inhibits the −1 Ribosomal Frameshifting of SARS-Coronavirus by Structure-Based Virtual Screening

(2011) So-Jung Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pleuromutilin and its Derivatives-The Lead Compounds for Novel Antibiotics

(2011) Y. -Z. Tang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Achieving a Golden Mean: Mechanisms by Which Coronaviruses Ensure Synthesis of the Correct Stoichiometric Ratios of Viral Proteins

(2010) E. P. Plant et al.   JOURNAL OF VIROLOGY

Rapid, nondenaturing RNA purification using weak anion-exchange fast performance liquid chromatography

(2010) L. E. Easton et al.   RNA

A homogeneous cell-based bicistronic fluorescence assay for high-throughput identification of drugs that perturb viral gene recoding and read-through of nonsense stop codons

(2009) T. S. Cardno et al.   RNA

Improved free energy parameters for RNA pseudoknotted secondary structure prediction

(2009) M. S. Andronescu et al.   RNA