SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion

(2022) Setu M. Vora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

(2022) Quirin Hammer et al.   Cell Reports

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

(2022) Mohammad Afsar et al.   eLife

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

(2022) Ceri Alan Fielding et al.   eLife

Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza

(2022) Demi Brownlie et al.   Frontiers in Immunology

HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells

(2022) Pia Fittje et al.   PLoS Pathogens

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

(2021) Can Liu et al.   CELL

The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression

(2021) Wei Huang et al.   JOURNAL OF IMMUNOLOGY

Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity

(2021) Federica Bozzano et al.   PLoS Pathogens

Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19

(2021) Rohitash Yadav et al.   Cells

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

(2021) Benjamin Krämer et al.   IMMUNITY

Abnormality in the NK-cell population is prolonged in severe COVID-19 patients

(2021) Galam Leem et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

(2021) Aaron J. Wilk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics

(2021) Nagarjuna R. Cheemarla et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

(2021) Christine Vazquez et al.   PLoS One

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

(2021) Mario Witkowski et al.   NATURE

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

(2021) Ji-Seung Yoo et al.   Nature Communications

Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition

(2021) Shuai Yuan et al.   Frontiers in Microbiology

An Infectious cDNA Clone of SARS-CoV-2

(2020) Xuping Xie et al.   Cell Host & Microbe

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

(2020) Meijuan Zheng et al.   Cellular & Molecular Immunology

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Treated HIV Infection Alters Phenotype but Not HIV-Specific Function of Peripheral Blood Natural Killer Cells

(2020) Nancy Q. Zhao et al.   Frontiers in Immunology

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

(2020) Natacha S. Ogando et al.   JOURNAL OF GENERAL VIROLOGY

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

(2020) Ahmad Abu Turab Naqvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Unique immunological profile in patients with COVID-19

(2020) Stefania Varchetta et al.   Cellular & Molecular Immunology

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs

(2020) Yuan-Qin Min et al.   Frontiers in Microbiology

Natural killer cell immunotypes related to COVID-19 disease severity

(2020) Christopher Maucourant et al.   Science Immunology

Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19

(2020) Mohammed Osman et al.   Blood Advances

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

(2020) Steffen Klein et al.   Nature Communications

Convergent Evolution by Cancer and Viruses in Evading the NKG2D Immune Response

(2020) Richard Baugh et al.   Cancers

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

(2020) Giuseppina Mariano et al.   Frontiers in Molecular Biosciences

Exploiting NK Cell Surveillance Pathways for Cancer Therapy

(2019) Alexander Barrow et al.   Cancers

Decay of the Stress-Induced Ligand MICA Is Controlled by the Expression of an Alternative 3′ Untranslated Region

(2018) Tirtsah Toledano et al.   JOURNAL OF IMMUNOLOGY

Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

(2018) Brogan Yarzabek et al.   eLife

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

(2017) Ceri A Fielding et al.   eLife

A short half-life of ULBP1 at the cell surface due to internalization and proteosomal degradation

(2016) Lola Fernández-Messina et al.   IMMUNOLOGY AND CELL BIOLOGY

Roles of natural killer cells in antiviral immunity

(2016) Stephen N Waggoner et al.   Current Opinion in Virology

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation

(2014) Ceri A. Fielding et al.   PLoS Pathogens

RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells

(2011) M. T. Zdrenghea et al.   EUROPEAN RESPIRATORY JOURNAL

Natural Killer Cell Responses to Viral Infection

(2011) Joshua D. Brandstadter et al.   Journal of Innate Immunity

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Degranulation of Natural Killer Cells Following Interaction with HIV-1-Infected Cells Is Hindered by Downmodulation of NTB-A by Vpu

(2010) Ankur H. Shah et al.   Cell Host & Microbe

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing

(2009) J. Richard et al.   BLOOD

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

(2009) Jeffrey Ward et al.   PLoS Pathogens

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Natural killer cell recognition of missing self

(2008) Klas Kärre   NATURE IMMUNOLOGY