Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus

Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis

(2022) Simon Witzel et al.   JAMA Neurology

Smarter adaptive platform clinical trials in neurology: a showcase for UK innovation

(2022) Arpan R. Mehta et al.   BRAIN

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

(2022) Charis Wong et al.   BMJ Open

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

(2022) Timothy M. Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trials for neurodegenerative diseases: time to innovate

(2021) Arpan R Mehta et al.   LANCET NEUROLOGY

Feast or famine in multiple sclerosis therapeutics

(2020) Robert J Fox   LANCET NEUROLOGY

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

(2020) Jeremy Chataway et al.   LANCET NEUROLOGY

Long‐Term Survival of Participants in the CENTAUR Trial of Sodium Phenylbutyrate‐Taurursodiol in ALS

(2020) Sabrina Paganoni et al.   MUSCLE & NERVE

Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis

(2020) Sabrina Paganoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

(2019) Leonard H. van den Berg et al.   NEUROLOGY

Reproducibility and Rigor in Animal-Based Research

(2019) Malcolm Macleod et al.   ILAR JOURNAL

Monotherapy versus combination therapy for multidrug-resistant Gram-negative infections: Systematic Review and Meta-Analysis

(2019) Adrian Schmid et al.   Scientific Reports

Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model

(2018) Henk-Jan Westeneng et al.   LANCET NEUROLOGY

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

(2018) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

(2018) Peter Connick et al.   BMJ Open

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Cladribine to Treat Relapsing Forms of Multiple Sclerosis

(2017) Gavin Giovannoni   Neurotherapeutics

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Rituximab in multiple sclerosis

(2016) Jonatan Salzer et al.   NEUROLOGY

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trazodone and Cognitive Performance in Alzheimer Disease

(2015) Einstein Francisco Camargos et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

(2015) Hanna M. Vesterinen et al.   PLoS One

How to increase value and reduce waste when research priorities are set

(2014) Iain Chalmers et al.   LANCET

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Neuroprotective Effects of Psychotropic Drugs in Huntington’s Disease

(2013) Edward Lauterbach   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

Alemtuzumab for multiple sclerosis

(2012) The Lancet   LANCET

Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial

(2012) Alasdair J Coles et al.   LANCET

A pilot trial of memantine and riluzole in ALS: Correlation to CSF biomarkers

(2010) Todd D. Levine et al.   Amyotrophic Lateral Sclerosis

A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis

(2010) Mamede de Carvalho et al.   Amyotrophic Lateral Sclerosis

Atorvastatin treatment attenuates motor neuron degeneration in wobbler mice

(2009) Konosuke Iwamoto et al.   Amyotrophic Lateral Sclerosis

The use of an antagonist 5-HT2a/c for depression and motor function in Parkinson' disease

(2009) Antonio Luiz dos Santos Werneck et al.   ARQUIVOS DE NEURO-PSIQUIATRIA