Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis

(2022) Simon Witzel et al.   JAMA Neurology

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

(2021) Arpan R. Mehta et al.   ACTA NEUROPATHOLOGICA

Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development

(2021) Sabrina Paganoni et al.   ANNALS OF NEUROLOGY

Trials for neurodegenerative diseases: time to innovate

(2021) Arpan R Mehta et al.   LANCET NEUROLOGY

Adding new experimental arms to randomised clinical trials: Impact on error rates

(2020) Babak Choodari-Oskooei et al.   Clinical Trials

Design, analysis and reporting of multi-arm trials and strategies to address multiple testing

(2020) Ayodele Odutayo et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification

(2020) Richard A Parker et al.   Clinical Trials

TRICALS: creating a highway toward a cure

(2020) Ruben P.A. van Eijk et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Refining eligibility criteria for amyotrophic lateral sclerosis clinical trials

(2019) Ruben P.A. van Eijk et al.   NEUROLOGY

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

(2019) Leonard H. van den Berg et al.   NEUROLOGY

Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

(2019) Jesus S. Mora et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS

(2018) Christopher Crockford et al.   NEUROLOGY

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

(2018) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

(2018) Peter Connick et al.   BMJ Open

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Living systematic review: 1. Introduction—the why, what, when, and how

(2017) Julian H. Elliott et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

(2015) Hanna M. Vesterinen et al.   PLoS One

The PRO-ACT database: Design, initial analyses, and predictive features

(2014) N. Atassi et al.   NEUROLOGY

SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials

(2013) An-Wen Chan et al.   ANNALS OF INTERNAL MEDICINE

Neuroprotective Effects of Psychotropic Drugs in Huntington’s Disease

(2013) Edward Lauterbach   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study

(2011) Julie Phukan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A pilot trial of memantine and riluzole in ALS: Correlation to CSF biomarkers

(2010) Todd D. Levine et al.   Amyotrophic Lateral Sclerosis

A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis

(2010) Mamede de Carvalho et al.   Amyotrophic Lateral Sclerosis