150th Anniversary Series: Desmosomes and the Hallmarks of Cancer

Desmosomal Cadherins and Signaling: Lessons from Autoimmune Disease

(2014) Volker Spindler et al.   CELL COMMUNICATION AND ADHESION

150th anniversary series: Desmosomes in physiology and disease

(2014) Nicola Cirillo   CELL COMMUNICATION AND ADHESION

Desmosomes in the Heart: A Review of Clinical and Mechanistic Analyses

(2014) Dipal M. Patel et al.   CELL COMMUNICATION AND ADHESION

Desmosomal Adhesion In Vivo

(2014) Mohamed Berika et al.   CELL COMMUNICATION AND ADHESION

Plakophilins in Desmosomal Adhesion and Signaling

(2014) Mechthild Hatzfeld et al.   CELL COMMUNICATION AND ADHESION

iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function

(2014) Matthew A. Brooke et al.   HUMAN MOLECULAR GENETICS

Galectin-3 Regulates Desmoglein-2 and Intestinal Epithelial Intercellular Adhesion

(2014) Kun Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adducin Is Required for Desmosomal Cohesion in Keratinocytes

(2014) Vera Rötzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different roles of cadherins in the assembly and structural integrity of the desmosome complex

(2014) Molly Lowndes et al.   JOURNAL OF CELL SCIENCE

An EMMPRIN- -catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions

(2014) V. Moreno et al.   JOURNAL OF CELL SCIENCE

The Desmosomal Protein Desmoglein 1 Aids Recovery of Epidermal Differentiation after Acute UV Light Exposure

(2014) Jodi L. Johnson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Loss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin

(2014) Michal Mlacki et al.   PLoS One

Desmosome Assembly and Disassembly Are Membrane Raft-Dependent

(2014) Sara N. Stahley et al.   PLoS One

Association of DSC3 mRNA Down-Regulation in Prostate Cancer with Promoter Hypermethylation and Poor Prognosis

(2014) Jincheng Pan et al.   PLoS One

Characterization of Desmoglein Expression in the Normal Prostatic Gland. Desmoglein 2 Is an Independent Prognostic Factor for Aggressive Prostate Cancer

(2014) Alison G. Barber et al.   PLoS One

Aberrant expression and altered cellular localization of desmosomal and hemidesmosomal proteins are associated with aggressive clinicopathological features of oral squamous cell carcinoma

(2014) Zhao Xin et al.   VIRCHOWS ARCHIV

Regulation of Desmocollin3 Expression by Promoter Hypermethylation is Associated with Advanced Esophageal Adenocarcinomas

(2014) Qinggang Wang et al.   Journal of Cancer

A family with a complex clinical presentation characterized by arrhythmogenic right ventricular dysplasia/cardiomyopathy and features of branchio-oculo-facial syndrome

(2013) Brittney Murray et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Colon tumour secretopeptidome: Insights into endogenous proteolytic cleavage events in the colon tumour microenvironment

(2013) David W. Greening et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Patterns in Space: Coordinating Adhesion and Actomyosin Contractility at E-cadherin Junctions

(2013) Selwin Kaixiang Wu et al.   CELL COMMUNICATION AND ADHESION

Desmosomal adhesion and pemphigus vulgaris: the first half of the story

(2013) Nicola Cirillo et al.   CELL COMMUNICATION AND ADHESION

Structural and Functional Diversity of Desmosomes

(2013) Robert M. Harmon et al.   CELL COMMUNICATION AND ADHESION

The influence of desmocollin 1–3 expression on prognosis after curative resection of colorectal liver metastases

(2013) Silke Schüle et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

A Pathophysiologic Role for Epidermal Growth Factor Receptor in Pemphigus Acantholysis

(2013) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation

(2013) A. Wolf et al.   JOURNAL OF CELL SCIENCE

Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3 

(2013) Z. Aktary et al.   JOURNAL OF CELL SCIENCE

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

(2013) Robert M. Harmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Plakoglobin as a Regulator of Desmocollin Gene Expression

(2013) Etienne Tokonzaba et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plakins, a Versatile Family of Cytolinkers: Roles in Skin Integrity and in Human Diseases

(2013) Jamal-Eddine Bouameur et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

In Vitro Assessment of IL-4- or IL-13-Mediated Changes in the Structural Components of Keratinocytes in Mice and Humans

(2013) Miyuki Omori-Miyake et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanistic Basis of Desmosome-Targeted Diseases

(2013) Caezar Al-Jassar et al.   JOURNAL OF MOLECULAR BIOLOGY

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

(2013) Changsung Kim et al.   NATURE

Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation

(2013) L Brown et al.   ONCOGENE

Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signaling

(2013) R Kamekura et al.   ONCOGENE

Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion

(2013) Eva Hartlieb et al.   PLoS One

DSG3 Facilitates Cancer Cell Growth and Invasion through the DSG3-Plakoglobin-TCF/LEF-Myc/Cyclin D1/MMP Signaling Pathway

(2013) Yin-Ju Chen et al.   PLoS One

Plakoglobin Represses SATB1 Expression and Decreases In Vitro Proliferation, Migration and Invasion

(2013) Zackie Aktary et al.   PLoS One

Desmosome assembly and dynamics

(2013) Oxana Nekrasova et al.   TRENDS IN CELL BIOLOGY

The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells

(2012) Kenichi Kume et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer

(2012) Tiantian Cui et al.   CARCINOGENESIS

Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/β-catenin signaling pathway in human lung cancer

(2012) Linlin Yang et al.   CARCINOGENESIS

Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics

(2012) Siu Man Tsang et al.   EXPERIMENTAL CELL RESEARCH

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome

(2012) Giustina Ferone et al.   HUMAN MOLECULAR GENETICS

Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma

(2012) Thomas Knösel et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer

(2012) Yong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Plakoglobin in Epidermis Leads to Keratoderma

(2012) Deqiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Motility of Triple-negative Breast Cancer Cells Is Due to Repression of Plakoglobin Gene by Metastasis Modulator Protein SLUG

(2012) Charvann K. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal unique region of desmoglein 2 inhibits its internalization via tail–tail interactions

(2012) Jing Chen et al.   JOURNAL OF CELL BIOLOGY

Plakoglobin-dependent regulation of keratinocyte apoptosis by Rnd3

(2012) Katie R. Ryan et al.   JOURNAL OF CELL SCIENCE

Diagnostic and prognostic impact of desmocollins in human lung cancer

(2012) Tiantian Cui et al.   JOURNAL OF CLINICAL PATHOLOGY

The Assay that Defines Desmosome Hyper-Adhesion

(2012) David R. Garrod   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris

(2012) Siu Man Tsang et al.   JOURNAL OF PATHOLOGY

The Desmosomal Armadillo Protein Plakoglobin Regulates Prostate Cancer Cell Adhesion and Motility through Vitronectin-Dependent Src Signaling

(2012) Carrie A. Franzen et al.   PLoS One

Critical Role of Klf5 in Regulating Gene Expression during Post-Eyelid Opening Maturation of Mouse Corneas

(2012) Doreswamy Kenchegowda et al.   PLoS One

Unimpaired Skin Carcinogenesis in Desmoglein 3 Knockout Mice

(2012) Sylvain Baron et al.   PLoS One

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

DSC3 expression is regulated by p53 and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer

(2011) T Cui et al.   BRITISH JOURNAL OF CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Altered Desmosomal Proteins in Granulomatous Myocarditis and Potential Pathogenic Links to Arrhythmogenic Right Ventricular Cardiomyopathy

(2011) Angeliki Asimaki et al.   Circulation-Arrhythmia and Electrophysiology

Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton

(2011) Brett J. Roberts et al.   EXPERIMENTAL CELL RESEARCH

Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes

(2011) Oxana E. Nekrasova et al.   JOURNAL OF CELL BIOLOGY

Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma

(2011) Z. Hamidov et al.   JOURNAL OF CLINICAL PATHOLOGY

Desmoglein as a Target in Skin Disease and Beyond

(2011) Masayuki Amagai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell-cell connectivity: desmosomes and disease

(2011) Matthew A Brooke et al.   JOURNAL OF PATHOLOGY

Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling

(2011) Keli Kolegraff et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of desmocollin 3 in skin tumor development and progression

(2011) Jiangli Chen et al.   MOLECULAR CARCINOGENESIS

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

(2011) Cory L. Simpson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for caveolin-1 in desmoglein binding and desmosome dynamics

(2011) D Brennan et al.   ONCOGENE

Binding of pemphigus vulgaris IgG to antigens in desmosome core domains excludes immune complexes rather than directly splitting desmosomes

(2010) Y. Aoyama et al.   BRITISH JOURNAL OF DERMATOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Membrane-impermeable Cross-linking Provides Evidence for Homophilic, Isoform-specific Binding of Desmosomal Cadherins in Epithelial Cells

(2010) Zhuxiang Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kallikrein-5 Promotes Cleavage of Desmoglein-1 and Loss of Cell-Cell Cohesion in Oral Squamous Cell Carcinoma

(2010) Rong Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling

(2010) V. Todorovic et al.   JOURNAL OF CELL SCIENCE

Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and Can Be Reversed by Expression of Exogenous Dsg3

(2010) Jean M. Jennings et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of Tumor and Invasion Suppressor Gene Modulators in Bladder Cancer by Different Classes of Histone Deacetylase Inhibitors Using Reverse Phase Protein Arrays

(2010) Justin J. Gould et al.   JOURNAL OF UROLOGY

Ear Melanoma: The Sunbelt Melanoma Trial

(2010) Adam C. Augenstein et al.   LARYNGOSCOPE

Desmoglein 3, via an Interaction with E-cadherin, Is Associated with Activation of Src

(2010) Siu Man Tsang et al.   PLoS One

Increased expression of Dsg2 in malignant skin carcinomas

(2010) Donna Brennan et al.   Cell Adhesion & Migration

Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis

(2010) Veronica G. Beaudry et al.   PLoS Genetics

Genetic Deletion of the Desmosomal Component Desmoplakin Promotes Tumor Microinvasion in a Mouse Model of Pancreatic Neuroendocrine Carcinogenesis

(2010) Matthew G. H. Chun et al.   PLoS Genetics

The Role of Desmoglein-3 in the Diagnosis of Squamous Cell Carcinoma of the Lung

(2009) Cemile Dilara Savci-Heijink et al.   AMERICAN JOURNAL OF PATHOLOGY

The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history

(2009) Daiji Oka et al.   CANCER

Characterization of de novo synthesized proteins released from human colorectal tumour explants

(2009) Hong Jun Shi et al.   ELECTROPHORESIS

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

(2009) Spiro Getsios et al.   JOURNAL OF CELL BIOLOGY

Genome-Wide Profiling of Histone H3 Lysine 4 and Lysine 27 Trimethylation Reveals an Epigenetic Signature in Prostate Carcinogenesis

(2009) Xi-Song Ke et al.   PLoS One

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity

(2008) Philip Owens et al.   DEVELOPMENTAL BIOLOGY

Perturbed desmosomal cadherin expression in grainy head-like 1-null mice

(2008) Tomasz Wilanowski et al.   EMBO JOURNAL

Pemphigus Vulgaris IgG-induced Desmoglein-3 Endocytosis and Desmosomal Disassembly Are Mediated by a Clathrin- and Dynamin-independent Mechanism

(2008) Emmanuella Delva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plakophilin 2: a critical scaffold for PKCα that regulates intercellular junction assembly

(2008) Amanda E. Bass-Zubek et al.   JOURNAL OF CELL BIOLOGY

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing

(2008) Valerie Arnoux et al.   MOLECULAR BIOLOGY OF THE CELL

EGFR and ADAMs Cooperate to Regulate Shedding and Endocytic Trafficking of the Desmosomal Cadherin Desmoglein 2

(2008) Jodi L. Klessner et al.   MOLECULAR BIOLOGY OF THE CELL

Repression of the Desmocollin 2 Gene Expression in Human Colon Cancer Cells Is Relieved by the Homeodomain Transcription Factors Cdx1 and Cdx2

(2008) S. Funakoshi et al.   MOLECULAR CANCER RESEARCH

Loss of desmoglein 1 expression associated with worse prognosis in head and neck squamous cell carcinoma patients

(2008) Michelle P. Wong et al.   PATHOLOGY

Regulation of Cadherin Trafficking

(2008) Emmanuella Delva et al.   TRAFFIC

The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery

(2007) Nicola Cirillo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY