The regulatory niche of intestinal stem cells

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

(2015) Jurian Schuijers et al.   Cell Stem Cell

Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

(2015) Samuel Asfaha et al.   Cell Stem Cell

SOX9 Maintains Reserve Stem Cells and Preserves Radioresistance in Mouse Small Intestine

(2015) Kyle C. Roche et al.   GASTROENTEROLOGY

Stem Cells Matter in Response to Fasting

(2015) Badi Sri Sailaja et al.   Cell Reports

Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status

(2015) Camilla A. Richmond et al.   Cell Reports

Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

(2015) Hua Tian et al.   Cell Reports

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

(2015) Dustin J. Flanagan et al.   Stem Cell Reports

Inflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges

(2015) Benjamin M. J. Owens   Frontiers in Immunology

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

(2014) Z. Kabiri et al.   DEVELOPMENT

Krüpple-Like Factor 5 Is Required for Proper Maintenance of Adult Intestinal Crypt Cellular Proliferation

(2014) Kristin N. Bell et al.   DIGESTIVE DISEASES AND SCIENCES

Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine

(2014) S. R. Moore et al.   Disease Models & Mechanisms

Regulatory T Cells Occupy an Isolated Niche in the Intestine that Is Antigen Independent

(2014) Lisa L. Korn et al.   Cell Reports

Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo

(2014) Adrianna K. San Roman et al.   Stem Cell Reports

Robust Cre-Mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus

(2014) Jurian Schuijers et al.   Stem Cell Reports

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay

(2013) Fengchao Wang et al.   GASTROENTEROLOGY

Evidence for a Crucial Role of Paneth Cells in Mediating the Intestinal Response to Injury

(2013) Lee Parry et al.   STEM CELLS

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

(2012) Henner F. Farin et al.   GASTROENTEROLOGY

Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice

(2012) Michael E. Rothenberg et al.   GASTROENTEROLOGY

Troy, a Tumor Necrosis Factor Receptor Family Member, Interacts With Lgr5 to Inhibit Wnt Signaling in Intestinal Stem Cells

(2012) Bohumil Fafilek et al.   GASTROENTEROLOGY

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

(2012) J. H. van Es et al.   MOLECULAR AND CELLULAR BIOLOGY

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

(2012) A. Durand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells

(2012) T.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CSF-1 receptor fashions the intestinal stem cell niche

(2012) Dilara Akcora et al.   Stem Cell Research

Intestinal myofibroblasts: targets for stem cell therapy

(2011) R. C. Mifflin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mesenchymal Cells of the Intestinal Lamina Propria

(2011) D.W. Powell et al.   Annual Review of Physiology

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Single-molecule transcript counting of stem-cell markers in the mouse intestine

(2011) Shalev Itzkovitz et al.   NATURE CELL BIOLOGY

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Hedgehog Is an Anti-Inflammatory Epithelial Signal for the Intestinal Lamina Propria

(2010) William J. Zacharias et al.   GASTROENTEROLOGY

Stem cells and cancer of the stomach and intestine

(2010) Robert G.J. Vries et al.   Molecular Oncology

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Wnt Signaling Regulates Snai1 Expression and Cellular Localization in the Mouse Intestinal Epithelial Stem Cell Niche

(2010) Katja Horvay et al.   STEM CELLS AND DEVELOPMENT

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

Prominin-1/CD133 Marks Stem Cells and Early Progenitors in Mouse Small Intestine

(2009) Hugo J. Snippert et al.   GASTROENTEROLOGY

The Role of the Visceral Mesoderm in the Development of the Gastrointestinal Tract

(2009) Valérie A. McLin et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

(2008) Orbicia Riccio et al.   EMBO REPORTS

Current View: Intestinal Stem Cells and Signaling

(2008) David H. Scoville et al.   GASTROENTEROLOGY

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells

(2008) D. T. Breault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA