Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

(2016) Lisa A. Lesniewski et al.   AGING CELL

Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults

(2016) Rachelle E. Kaplon et al.   Aging-US

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

Dietary Restriction and Nutrient Balance in Aging

(2016) Júlia Santos et al.   Oxidative Medicine and Cellular Longevity

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

(2016) Marie Boutant et al.   Cell Reports

Translational Geroscience: Emphasizing function to achieve optimal longevity

(2016) Douglas R. Seals et al.   Aging-US

Effects of Resistance Training With and Without Caloric Restriction on Arterial Stiffness in Overweight and Obese Older Adults

(2015) Margie E. Jefferson et al.   AMERICAN JOURNAL OF HYPERTENSION

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial

(2015) Dennis T Villareal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cellular and molecular biology of aging endothelial cells

(2015) Anthony J. Donato et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Arterial stiffness, the brain and cognition: A systematic review

(2014) Joel Singer et al.   AGEING RESEARCH REVIEWS

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

(2014) Lindsey B. Gano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

(2014) Julie A. Mattison et al.   Cell Metabolism

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

(2014) Amandine Chaix et al.   Cell Metabolism

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB

(2014) Ashley E. Walker et al.   CLINICAL SCIENCE

Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries

(2014) Douglas R. Seals   JOURNAL OF APPLIED PHYSIOLOGY

Supplementing exercise: translational considerations for nutraceutical and lifestyle interventions

(2014) Jessica R. Santos-Parker et al.   JOURNAL OF PHYSIOLOGY-LONDON

Time-restricted feeding and risk of metabolic disease: a review of human and animal studies

(2014) Jeff Rothschild et al.   NUTRITION REVIEWS

Meal frequency and timing in health and disease

(2014) Mark P. Mattson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exacerbated oxidative stress in the fasting liver according to fuel partitioning

(2014) Thierry Wasselin et al.   PROTEOMICS

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

AMPK activation—protean potential for boosting healthspan

(2013) Mark F. McCarty   AGE

Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries

(2013) Ashley E. Walker et al.   AGE

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

(2013) Anthony J. Donato et al.   AGING CELL

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Weight loss in obese adults 65years and older: A review of the controversy

(2013) Debra L. Waters et al.   EXPERIMENTAL GERONTOLOGY

Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism

(2013) Albino Carrizzo et al.   HYPERTENSION

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults

(2013) Rachel H.X. Wong et al.   JOURNAL OF HYPERTENSION

Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

(2013) Lasse Gliemann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dual Effects of Resveratrol on Arterial Damage Induced By Insulin Resistance in Aged Mice

(2013) S. Baron et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The autophagy enhancer spermidine reverses arterial aging

(2013) Thomas J. LaRocca et al.   MECHANISMS OF AGEING AND DEVELOPMENT

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol

(2013) Ning Xia et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial

(2013) Krista A Varady et al.   Nutrition Journal

Matrix Metalloproteinase-9: Many Shades of Function in Cardiovascular Disease

(2013) Andriy Yabluchanskiy et al.   PHYSIOLOGY

Lifelong Caloric Restriction Increases Working Memory in Mice

(2013) Angela Kuhla et al.   PLoS One

Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5

(2013) Bo Bai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

(2012) Gautham Yepuri et al.   AGING CELL

Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats

(2012) Protásio L. da Luz et al.   ATHEROSCLEROSIS

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Recent advances in calorie restriction research on aging

(2012) K.W. Chung et al.   EXPERIMENTAL GERONTOLOGY

Translational evidence that impaired autophagy contributes to arterial ageing

(2012) Thomas J. LaRocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

(2012) Jill P. Crandall et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism

(2012) Lisa A. Lesniewski et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Regulation of Cerebral Vascular Function by Sirtuin 1

(2012) NEGARA TAJBAKHSH et al.   MICROCIRCULATION

Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations

(2012) Cynthia M Kroeger et al.   Nutrition & Metabolism

Effects of Ramadan fasting on cardiovascular risk factors: a prospective observational study

(2012) Mohsen Nematy et al.   Nutrition Journal

Intermittent fasting during Ramadan attenuates proinflammatory cytokines and immune cells in healthy subjects

(2012) “Mo'ez Al-Islam” E. Faris et al.   NUTRITION RESEARCH

Perspectives of Targeting mTORC1–S6K1 in Cardiovascular Aging

(2012) Xiu-Fen Ming et al.   Frontiers in Physiology

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

(2011) Bradley S. Fleenor et al.   AGING CELL

Mitochondrial Oxidative Stress in Aortic Stiffening With Age

(2011) Rui-Hai Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans

(2011) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor  B and Forkhead Box O Phosphorylation

(2011) L. A. Lesniewski et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

(2011) Angana G. Rajapakse et al.   PLoS One

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

(2010) Catarina Rippe et al.   AGING CELL

Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta

(2010) Michela Zanetti et al.   EXPERIMENTAL GERONTOLOGY

Arterial Destiffening With Weight Loss in Overweight and Obese Middle-Aged and Older Adults

(2010) A. Laura Dengo et al.   HYPERTENSION

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

(2010) M N Harvie et al.   INTERNATIONAL JOURNAL OF OBESITY

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

(2010) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise

(2010) Bradley S. Fleenor et al.   JOURNAL OF PHYSIOLOGY-LONDON

Resveratrol, sirtuins, and the promise of a DR mimetic

(2010) Joseph A. Baur   MECHANISMS OF AGEING AND DEVELOPMENT

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

(2010) R.H.X. Wong et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

A possibility of nutriceuticals as an anti-aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis

(2010) Shin-ichiro Imai   PHARMACOLOGICAL RESEARCH

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

(2009) Shin-ichiro Imai   CELL BIOCHEMISTRY AND BIOPHYSICS

Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

(2009) Gary L. Pierce et al.   CIRCULATION

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

Effects of Caloric Restriction on Cardiovascular Aging in Non-human Primates and Humans

(2009) Christina Cruzen et al.   CLINICS IN GERIATRIC MEDICINE

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

RAGE signaling in inflammation and arterial aging

(2009) Li Lin   Frontiers in Bioscience-Landmark

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

(2009) Anna Csiszar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Aging in America in the Twenty-first Century: Demographic Forecasts from the MacArthur Foundation Research Network on an Aging Society

(2009) S. JAY OLSHANSKY et al.   MILBANK QUARTERLY

Caloric restriction improves memory in elderly humans

(2009) A. V. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

NO Targets SIRT1

(2008) Michael Potente et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Mechanisms Underlying Caloric Restriction and Lifespan Regulation

(2008) Zoltan Ungvari et al.   CIRCULATION RESEARCH

Weight Loss Alone Improves Conduit and Resistance Artery Endothelial Function in Young and Older Overweight/Obese Adults

(2008) Gary L. Pierce et al.   HYPERTENSION

Habitual exercise and arterial aging

(2008) Douglas R. Seals et al.   JOURNAL OF APPLIED PHYSIOLOGY

The danger of weight loss in the elderly

(2008) S. L. Miller et al.   Journal of Nutrition Health & Aging