Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains

Unnatural Amino Acids as Probes of Ligand-Receptor Interactions and Their Conformational Consequences

(2013) Stephan A. Pless et al.   Annual Review of Pharmacology and Toxicology

The Conserved Phenylalanine in the K+ Channel Voltage-Sensor Domain Creates a Barrier with Unidirectional Effects

(2013) Christine S. Schwaiger et al.   BIOPHYSICAL JOURNAL

S1–S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation

(2013) James R. Groome et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels

(2013) Yen May Cheng et al.   JOURNAL OF GENERAL PHYSIOLOGY

The voltage-sensing domain of a phosphatase gates the pore of a potassium channel

(2013) Cristina Arrigoni et al.   JOURNAL OF GENERAL PHYSIOLOGY

Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel

(2013) Marcel P. Goldschen-Ohm et al.   Nature Communications

Intermediate state trapping of a voltage sensor

(2012) Jérôme J. Lacroix et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

(2012) Jian Payandeh et al.   NATURE

Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor

(2012) D. L. Capes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

(2012) Emily C. McCusker et al.   Nature Communications

310-Helix Conformation Facilitates the Transition of a Voltage Sensor S4 Segment toward the Down State

(2011) Christine S. Schwaiger et al.   BIOPHYSICAL JOURNAL

Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro

(2011) Hiroshi Watanabe et al.   CIRCULATION

Contributions of Conserved Residues at the Gating Interface of Glycine Receptors

(2011) Stephan A. Pless et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R1 in the Shaker S4 occupies the gating charge transfer center in the resting state

(2011) Meng-chin A. Lin et al.   JOURNAL OF GENERAL PHYSIOLOGY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Contributions of counter-charge in a potassium channel voltage-sensor domain

(2011) Stephan A Pless et al.   Nature Chemical Biology

Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor

(2011) J. J. Lacroix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor

(2011) P. G. DeCaen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for gating charge movement in the voltage sensor of a sodium channel

(2011) V. Yarov-Yarovoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations

(2011) L. Delemotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels

(2011) Stephan A. Pless et al.   Nature Communications

Coupling between Residues on S4 and S1 Defines the Voltage-Sensor Resting Conformation in NaChBac

(2010) Tzur Paldi et al.   BIOPHYSICAL JOURNAL

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation

(2010) Dick Wu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channel

(2010) Yukiko Muroi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Sequential formation of ion pairs during activation of a sodium channel voltage sensor

(2009) Paul G. DeCaen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-linear intramolecular interactions and voltage sensitivity of a KV1 family potassium channel from Polyorchis penicillatus (Eschscholtz 1829)

(2008) T. L. Klassen et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

How membrane proteins sense voltage

(2008) Francisco Bezanilla   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation

(2008) P. G. DeCaen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA