A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens

Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

(2021) Luis M. de la Maza et al.   Expert Review of Vaccines

On-demand biomanufacturing of protective conjugate vaccines

(2021) Jessica C. Stark et al.   Science Advances

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

(2021) Keman Cheng et al.   Nature Communications

Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

(2021) Shiho Chiba et al.   Communications Biology

Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals

(2021) Leila Pourtalebi Jahromi et al.   ADVANCED DRUG DELIVERY REVIEWS

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

(2020) Min Li et al.   JOURNAL OF CONTROLLED RELEASE

Serum antibodies to phosphatidylcholine in MS

(2020) Maria Cruz Sádaba et al.   Neurology-Neuroimmunology & Neuroinflammation

Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins

(2020) Kavita Singh et al.   Communications Biology

GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines

(2020) Francesca Micoli et al.   Vaccines

Recent advances in the production of recombinant glycoconjugate vaccines

(2019) Emily Kay et al.   npj Vaccines

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells

(2019) Sjoerd T.T. Schetters et al.   Acta Biomaterialia

Comparing autotransporter β-domain configurations for their capacity to secrete heterologous proteins to the cell surface

(2018) Wouter S. P. Jong et al.   PLoS One

Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies

(2018) Taylor C. Stevenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Display of Recombinant Proteins on Bacterial Outer Membrane Vesicles by Using Protein Ligation

(2018) H. Bart van den Berg van Saparoea et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Glycoconjugate vaccines: Principles and mechanisms

(2018) Rino Rappuoli   Science Translational Medicine

Cell-free production of a functional oligomeric form of aChlamydiamajor outer-membrane protein (MOMP) for vaccine development

(2017) Wei He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection

(2017) Hannah C. Watkins et al.   MOLECULAR THERAPY

A water-soluble DsbB variant that catalyzes disulfide-bond formation in vivo

(2017) Dario Mizrachi et al.   Nature Chemical Biology

BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes

(2017) Martin Closter Jespersen et al.   NUCLEIC ACIDS RESEARCH

Tailoring Escherichia coli for the l-Rhamnose PBAD Promoter-Based Production of Membrane and Secretory Proteins

(2017) Anna Hjelm et al.   ACS Synthetic Biology

Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles

(2017) Alberto Grandi et al.   Frontiers in Oncology

A Rhizavidin Monomer with Nearly Multimeric Avidin-Like Binding Stability Against Biotin Conjugates

(2016) Jeong Min Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recombinant expression of Chlamydia trachomatis major outer membrane protein in E. Coli outer membrane as a substrate for vaccine research

(2016) Zhiyun Wen et al.   BMC MICROBIOLOGY

IgG subclass co-expression brings harmony to the quartet model of murine IgG function

(2016) Andrew M Collins   IMMUNOLOGY AND CELL BIOLOGY

Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission-blocking vaccine candidates

(2016) Shwu-Maan Lee et al.   MALARIA JOURNAL

Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies

(2016) Linxiao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice

(2016) C. Garrett Rappazzo et al.   VACCINE

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

(2016) Karl D. Brune et al.   Scientific Reports

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA

(2015) Susan Thrane et al.   PLoS One

Conjugate-like immunogens produced as protein capsular matrix vaccines

(2015) Ann Thanawastien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy

(2015) Dario Mizrachi et al.   Nature Communications

Microbial biosynthesis of designer outer membrane vesicles

(2014) Jenny L Baker et al.   CURRENT OPINION IN BIOTECHNOLOGY

Positional Assembly of Enzymes on Bacterial Outer Membrane Vesicles for Cascade Reactions

(2014) Miso Park et al.   PLoS One

Mechanistic Insight into the TH1-Biased Immune Response to Recombinant Subunit Vaccines Delivered by Probiotic Bacteria-Derived Outer Membrane Vesicles

(2014) Joseph A. Rosenthal et al.   PLoS One

Bacterial Vesicles in Marine Ecosystems

(2014) S. J. Biller et al.   SCIENCE

VaxCelerate II: Rapid development of a self-assembling vaccine for Lassa fever

(2014) Pierre Leblanc et al.   Human Vaccines & Immunotherapeutics

Pathogen-like particles: biomimetic vaccine carriers engineered at the nanoscale

(2013) Joseph A. Rosenthal et al.   CURRENT OPINION IN BIOTECHNOLOGY

Lipopolysaccharide Modifications of a Cholera Vaccine Candidate Based on Outer Membrane Vesicles Reduce Endotoxicity and Reveal the Major Protective Antigen

(2013) Deborah R. Leitner et al.   INFECTION AND IMMUNITY

Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity

(2013) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based engineering of streptavidin monomer with a reduced biotin dissociation rate

(2013) Daniel DeMonte et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis

(2013) J. Cuccui et al.   Open Biology

Adjuvant properties of meningococcal outer membrane vesicles and the use of adjuvants inNeisseria meningitidisprotein vaccines

(2011) Holly Sanders et al.   Expert Review of Vaccines

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Extracellular production of recombinant proteins using bacterial autotransporters

(2010) Wouter SP Jong et al.   CURRENT OPINION IN BIOTECHNOLOGY

Immunization withSalmonella entericaSerovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge withStreptococcus pneumoniae

(2010) Maneesha Muralinath et al.   INFECTION AND IMMUNITY

Naturally Produced Outer Membrane Vesicles from Pseudomonas aeruginosa Elicit a Potent Innate Immune Response via Combined Sensing of Both Lipopolysaccharide and Protein Components

(2010) T. N. Ellis et al.   INFECTION AND IMMUNITY

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cell Activation by Outer Membrane Vesicles—A Novel Virulence Mechanism

(2010) Maria Laura A. Perez Vidakovics et al.   PLoS Pathogens

How Bacterial Carbohydrates Influence the Adaptive Immune System

(2009) Fikri Y. Avci et al.   Annual Review of Immunology

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

(2009) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein

(2009) Guifeng Sun et al.   VACCINE

Protection of Wild-Type and Severe Combined Immunodeficiency Mice against an Intranasal Challenge by Passive Immunization with Monoclonal Antibodies to the Chlamydia trachomatis Mouse Pneumonitis Major Outer Membrane Protein

(2008) S. Pal et al.   INFECTION AND IMMUNITY

Engineered Bacterial Outer Membrane Vesicles with Enhanced Functionality

(2008) Jae-Young Kim et al.   JOURNAL OF MOLECULAR BIOLOGY