The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de‐risk trial programmes of novel agents
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de‐risk trial programmes of novel agents
Authors
Keywords
-
Journal
World Psychiatry
Volume 22, Issue 1, Pages 48-74
Publisher
Wiley
Online
2023-01-15
DOI
10.1002/wps.21056
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder
- (2022) Meryem Grabski et al. AMERICAN JOURNAL OF PSYCHIATRY
- Systematic review and meta-analysis of the placebo effect in panic disorder: Implications for research and clinical practice
- (2022) Masoud Ahmadzad-Asl et al. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
- Novel approaches to measuring neurocognitive functions in Alzheimer's disease clinical trials
- (2022) Scott Carlson et al. CURRENT OPINION IN NEUROLOGY
- Validity and utility of Hierarchical Taxonomy of Psychopathology ( HiTOP ): III . Emotional dysfunction superspectrum
- (2022) David Watson et al. World Psychiatry
- Representation and Outcomes of Individuals With Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials
- (2022) Heidi Taipale et al. JAMA Psychiatry
- Effect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial
- (2022) Herriot Tabuteau et al. AMERICAN JOURNAL OF PSYCHIATRY
- Neuroscience-based nomenclature of psychotropics: Progress report
- (2022) Joseph Zohar et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- The efficacy and safety of adjunctive intranasal esketamine treatment in major depressive disorder: a systematic review and meta-analysis
- (2022) Muhammad Youshay Jawad et al. Expert Opinion On Drug Safety
- Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis
- (2022) Anees Bahji et al. Expert Opinion On Drug Safety
- Ambulatory audio and video recording for digital phenotyping in schizophrenia: Adherence & data usability
- (2022) Tovah Cowan et al. PSYCHIATRY RESEARCH
- Associations among smartphone app-based measurements of mood, sleep and activity in bipolar disorder
- (2022) Yu-Ching Tseng et al. PSYCHIATRY RESEARCH
- Efficacy and safety/tolerability of antipsychotics in the treatment of adult patients with major depressive disorder: a systematic review and meta-analysis
- (2022) Taishiro Kishimoto et al. PSYCHOLOGICAL MEDICINE
- Efficacy and Safety of Roluperidone for the Treatment of Negative Symptoms of Schizophrenia
- (2022) Michael Davidson et al. SCHIZOPHRENIA BULLETIN
- Longitudinal symptom changes and association with home time in people with schizophrenia: An observational digital phenotyping study
- (2022) Tanvi Ranjan et al. SCHIZOPHRENIA RESEARCH
- The Feasibility and Utility of Harnessing Digital Health to Understand Clinical Trajectories in Medication Treatment for Opioid Use Disorder: D-TECT Study Design and Methodological Considerations
- (2022) Lisa A. Marsch et al. Frontiers in Psychiatry
- Digital phenotyping in depression diagnostics: Integrating psychiatric and engineering perspectives
- (2022) Jayesh Kamath et al. World Journal of Psychiatry
- The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management
- (2022) Roger S. McIntyre et al. World Psychiatry
- Ecological Momentary Assessment of Depressive Symptoms Using the mind.me Application: Convergence with the Patient Health Questionnaire-9 (PHQ-9)
- (2021) Roger S. McIntyre et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Bupropion and Naltrexone in Methamphetamine Use Disorder
- (2021) Madhukar H. Trivedi et al. NEW ENGLAND JOURNAL OF MEDICINE
- The clinical characterization of the patient with primary psychosis aimed at personalization of management
- (2021) Mario Maj et al. World Psychiatry
- Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial
- (2021) Sara Costi et al. AMERICAN JOURNAL OF PSYCHIATRY
- AVP-786 as a promising treatment option for Alzheimer’s Disease including agitation
- (2021) Rita Khoury et al. EXPERT OPINION ON PHARMACOTHERAPY
- Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia
- (2021) Stephen K. Brannan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Discovery of Non‐racemic Amisulpride to Maximize Benefit/Risk of 5‐HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders
- (2021) Seth C. Hopkins et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status
- (2021) Ioline D. Henter et al. CNS DRUGS
- Sleep quality and outcome of exposure therapy in adults with social anxiety disorder
- (2021) Christina D. Dutcher et al. DEPRESSION AND ANXIETY
- Placebo and nocebo responses in randomised, controlled trials of medications for ADHD: a systematic review and meta-analysis
- (2021) Stephen V. Faraone et al. MOLECULAR PSYCHIATRY
- MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study
- (2021) Jennifer M. Mitchell et al. NATURE MEDICINE
- Trial of Psilocybin versus Escitalopram for Depression
- (2021) Robin Carhart-Harris et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preventive psychiatry: a blueprint for improving the mental health of young people
- (2021) Paolo Fusar‐Poli et al. World Psychiatry
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum
- (2021) Robert F. Krueger et al. World Psychiatry
- Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review
- (2021) Christoph U. Correll et al. World Psychiatry
- Universal and Selective Interventions to Prevent Poor Mental Health Outcomes in Young People: Systematic Review and Meta-analysis
- (2021) Gonzalo Salazar de Pablo et al. HARVARD REVIEW OF PSYCHIATRY
- Cognitive Enhancers in Schizophrenia: A Systematic Review and Meta-Analysis of Alpha-7 Nicotinic Acetylcholine Receptor Agonists for Cognitive Deficits and Negative Symptoms
- (2021) María Recio-Barbero et al. Frontiers in Psychiatry
- Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta‐regression analysis to develop an enrichment strategy
- (2021) Bruno Scherrer et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Preventing new episodes of bipolar disorder in adults: Systematic review and meta-analysis of randomized controlled trials
- (2021) Anastasiya Nestsiarovich et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Trial of Pimavanserin in Dementia-Related Psychosis
- (2021) Pierre N. Tariot et al. NEW ENGLAND JOURNAL OF MEDICINE
- A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression
- (2021) Peter Nagele et al. Science Translational Medicine
- The growing field of digital psychiatry: current evidence and the future of apps, social media, chatbots, and virtual reality
- (2021) John Torous et al. World Psychiatry
- Review of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders
- (2021) Autumn Walkerly et al. Drug Design Development and Therapy
- Approval of Aducanumab for Alzheimer Disease—the FDA’s Perspective
- (2021) Billy Dunn et al. JAMA Internal Medicine
- Effect of Zuranolone vs Placebo in Postpartum Depression
- (2021) Kristina M. Deligiannidis et al. JAMA Psychiatry
- Ibudilast attenuates alcohol cue–elicited frontostriatal functional connectivity in alcohol use disorder
- (2021) Elizabeth M. Burnette et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial
- (2021) Maurizio Fava et al. AMERICAN JOURNAL OF PSYCHIATRY
- The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer’s disease
- (2021) Akash Verma et al. BIOORGANIC CHEMISTRY
- A Randomized, Double-blind, Placebo-controlled Proof-of-Concept Trial to Evaluate the Efficacy and Safety of Non-racemic Amisulpride (SEP-4199) for the Treatment of Bipolar I Depression
- (2021) Antony Loebel et al. JOURNAL OF AFFECTIVE DISORDERS
- Meta-Analysis: Pediatric Placebo Response in Depression Trials Does Not Replicate in Anxiety and Obsessive-Compulsive Disorder Trials
- (2021) Madeeha Nasir et al. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
- Site-independent confirmation of primary site-based PANSS ratings in a schizophrenia trial
- (2021) Steven D. Targum et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Machine Learning Identifies Digital Phenotyping Measures Most Relevant to Negative Symptoms in Psychotic Disorders: Implications for Clinical Trials
- (2021) Sayli M Narkhede et al. SCHIZOPHRENIA BULLETIN
- The efficacy and safety of dual orexin receptor antagonists in primary insomnia: A systematic review and network meta-analysis
- (2021) Tao Xue et al. SLEEP MEDICINE REVIEWS
- Differential power of placebo across major psychiatric disorders: a preliminary meta-analysis and machine learning study
- (2021) Bo Cao et al. Scientific Reports
- Evaluating the utility of digital phenotyping to predict health outcomes in schizophrenia: protocol for the HOPE-S observational study
- (2021) Nur Amirah Abdul Rashid et al. BMJ Open
- Association of Single-blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants
- (2021) Amelia J. Scott et al. JAMA Psychiatry
- Limitations in Research on Maintenance Treatment for Individuals With Schizophrenia
- (2021) Mark Abie Horowitz et al. JAMA Psychiatry
- On Blurry Boundaries When Defining Digital Biomarkers: How Much Biology Needs to Be in a Digital Biomarker?
- (2021) Christian Montag et al. Frontiers in Psychiatry
- Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults
- (2021) Brett D. M. Jones et al. JAMA Network Open
- Digital biomarkers of anxiety disorder symptom changes: Personalized deep learning models using smartphone sensors accurately predict anxiety symptoms from ecological momentary assessments
- (2021) Nicholas C. Jacobson et al. BEHAVIOUR RESEARCH AND THERAPY
- Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial
- (2020) W. Joseph Herring et al. Alzheimers & Dementia
- Success and efficiency of phase 2/3 adjunctive trials for MDD funded by industry: a systematic review
- (2020) Naji C. Salloum et al. MOLECULAR PSYCHIATRY
- Efficacy of adjunctive infliximab vs. placebo in the treatment of anhedonia in bipolar I/II depression
- (2020) Yena Lee et al. BRAIN BEHAVIOR AND IMMUNITY
- Antidepressants and suicidality: A re-analysis of the re-analysis
- (2020) Jakob André Kaminski et al. JOURNAL OF AFFECTIVE DISORDERS
- THE UTILITY OF SMARTPHONE-BASED, ECOLOGICAL MOMENTARY ASSESSMENT FOR DEPRESSIVE SYMPTOMS
- (2020) Samantha J. Yim et al. JOURNAL OF AFFECTIVE DISORDERS
- Efficacy of psychedelic treatments on depressive symptoms: A meta-analysis
- (2020) Bruno Romeo et al. JOURNAL OF PSYCHOPHARMACOLOGY
- A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
- (2020) Kenneth S. Koblan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum
- (2020) Roman Kotov et al. World Psychiatry
- Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms
- (2020) Raymond F. Anton et al. JAMA Internal Medicine
- Placebo response rates in trials of antidepressant drugs in adults with clinical depression: Increasing, decreasing, constant or all of the above?
- (2020) Gordon Parker et al. JOURNAL OF AFFECTIVE DISORDERS
- A meta-analysis of the potential antidepressant effects of buprenorphine versus placebo as an adjunctive pharmacotherapy for treatment-resistant depression
- (2020) Adam Dinoff et al. JOURNAL OF AFFECTIVE DISORDERS
- The Antidiabetic Metformin as an Adjunct to Antidepressants in Patients with Major Depressive Disorder: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial
- (2020) Mahmoud S. Abdallah et al. Neurotherapeutics
- Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials
- (2020) Lisa Jerome et al. PSYCHOPHARMACOLOGY
- Association of End Point Definition and Randomized Clinical Trial Duration in Clinical Trials of Schizophrenia Medications
- (2020) Islam R. Younis et al. JAMA Psychiatry
- Using Language Processing and Speech Analysis for the Identification of Psychosis and Other Disorders
- (2020) Cheryl Mary Corcoran et al. Biological Psychiatry-Cognitive Neuroscience and Neuroimaging
- Dose Timing of D-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder
- (2020) Jasper A. J. Smits et al. JAMA Network Open
- Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study
- (2020) Christoph U. Correll et al. AMERICAN JOURNAL OF PSYCHIATRY
- Risk and protective factors for mental disorders with onset in childhood/adolescence: An umbrella review of published meta-analyses of observational longitudinal studies
- (2020) Marco Solmi et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- The clinical characterization of the adult patient with depression aimed at personalization of management
- (2020) Mario Maj et al. World Psychiatry
- Placebo response in pharmacological and dietary supplement trials of autism spectrum disorder (ASD): systematic review and meta-regression analysis
- (2020) Spyridon Siafis et al. Molecular Autism
- Antidepressants in Children and Adolescents: Meta-Review of Efficacy, Tolerability and Suicidality in Acute Treatment
- (2020) Katharine Boaden et al. Frontiers in Psychiatry
- Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies
- (2020) Kristoffer A. A. Andersen et al. ACTA PSYCHIATRICA SCANDINAVICA
- Efficacy and safety of AXS‐05, a novel, oral, NMDA‐receptor antagonist with multimodal activity, in agitation associated with Alzheimer’s disease: Results from ADVANCE‐1, a phase 2/3, double‐blind, active and placebo‐controlled trial
- (2020) Cedric O'Gorman et al. Alzheimers & Dementia
- Assessing the relationship between routine and schizophrenia symptoms with passively sensed measures of behavioral stability
- (2020) Joy He-Yueya et al. npj Schizophrenia
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder
- (2020) Alan K. Davis et al. JAMA Psychiatry
- Mitigation of Olanzapine-Induced Weight Gain With Samidorphan, an Opioid Antagonist: A Randomized Double-Blind Phase 2 Study in Patients With Schizophrenia
- (2019) William F. Martin et al. AMERICAN JOURNAL OF PSYCHIATRY
- Randomized placebo controlled trial of nabilone for agitation in Alzheimer's disease
- (2019) Nathan Herrmann et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials
- (2019) Michael C. Mithoefer et al. PSYCHOPHARMACOLOGY
- Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression
- (2019) Roger S. McIntyre et al. JAMA Psychiatry
- Disconnection of drug-response and placebo-response in acute-phase antipsychotic drug trials on schizophrenia? Meta-regression analysis
- (2019) Stefan Leucht et al. NEUROPSYCHOPHARMACOLOGY
- Effect of Adjunctive Estradiol on Schizophrenia Among Women of Childbearing Age
- (2019) Mark Weiser et al. JAMA Psychiatry
- Trial of SAGE-217 in Patients with Major Depressive Disorder
- (2019) Handan Gunduz-Bruce et al. NEW ENGLAND JOURNAL OF MEDICINE
- Brexanolone for postpartum depression: A meta-analysis of randomized controlled studies
- (2019) Wei Zheng et al. PSYCHIATRY RESEARCH
- Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline
- (2019) Allison A. Feduccia et al. Frontiers in Psychiatry
- Efficacy and Safety of Brexpiprazole for the Treatment of Agitation in Alzheimer's Dementia: Two 12-Week, Randomized, Double-Blind, Placebo-Controlled Trials
- (2019) George T. Grossberg et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder
- (2019) Stefan G. Hofmann et al. PLoS One
- Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia
- (2019) Stefan Leucht et al. AMERICAN JOURNAL OF PSYCHIATRY
- Voice patterns in schizophrenia: A systematic review and Bayesian meta-analysis
- (2019) Alberto Parola et al. SCHIZOPHRENIA RESEARCH
- Effects of Mirtazapine for Methamphetamine Use Disorder Among Cisgender Men and Transgender Women Who Have Sex With Men
- (2019) Phillip O. Coffin et al. JAMA Psychiatry
- Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial
- (2018) Philip McGuire et al. AMERICAN JOURNAL OF PSYCHIATRY
- Baclofen in the treatment of alcohol dependence with or without liver disease: multisite, randomised, double-blind, placebo-controlled trial
- (2018) Kirsten C. Morley et al. BRITISH JOURNAL OF PSYCHIATRY
- Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
- (2018) Andrea Cipriani et al. LANCET
- Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study
- (2018) Clive Ballard et al. LANCET NEUROLOGY
- Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial
- (2018) Fernanda Palhano-Fontes et al. PSYCHOLOGICAL MEDICINE
- Treatment of tardive dyskinesia with VMAT-2 inhibitors: a systematic review and meta-analysis of randomized controlled trials
- (2018) Marco Solmi et al. Drug Design Development and Therapy
- Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition
- (2018) Jennifer L. Gordon et al. JAMA Psychiatry
- What’s in a Name? Moving to Neuroscience-Based Nomenclature in Pediatric Psychopharmacology
- (2018) Ryan S. Sultan et al. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
- Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials
- (2018) Samantha Meltzer-Brody et al. LANCET
- Increasing Diversity in Clinical Trials: Overcoming Critical Barriers
- (2018) Luther T. Clark et al. CURRENT PROBLEMS IN CARDIOLOGY
- Machine learning methods for automatic pain assessment using facial expression information
- (2018) Dianbo Liu et al. MEDICINE
- Opioid system modulation with buprenorphine/samidorphan combination for major depressive disorder: two randomized controlled studies
- (2018) Maurizio Fava et al. MOLECULAR PSYCHIATRY
- Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)
- (2018) Maurizio Fava et al. MOLECULAR PSYCHIATRY
- Pimavanserin for Parkinson's Disease psychosis: Effects stratified by baseline cognition and use of cognitive-enhancing medications
- (2018) Alberto J. Espay et al. MOVEMENT DISORDERS
- Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency
- (2018) Olivier Collignon et al. Trials
- Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants
- (2017) David Mischoulon et al. JOURNAL OF AFFECTIVE DISORDERS
- Raloxifene Plus Antipsychotics Versus Placebo Plus Antipsychotics in Severely Ill Decompensated Postmenopausal Women With Schizophrenia or Schizoaffective Disorder
- (2017) Mark Weiser et al. JOURNAL OF CLINICAL PSYCHIATRY
- Guarding the Gate
- (2017) Marlene P. Freeman et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial
- (2017) Stephen Kanes et al. LANCET
- Psychiatry & the psychedelic drugs. Past, present & future
- (2017) James J.H. Rucker et al. NEUROPHARMACOLOGY
- Alpha-7 nicotinic agonists for cognitive deficits in neuropsychiatric disorders: A translational meta-analysis of rodent and human studies
- (2017) Alan S. Lewis et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Efficacy and Safety of Bitopertin in Patients with Schizophrenia and Predominant Negative Symptoms: Subgroup Analysis of Japanese Patients from the Global Randomized Phase 2 Trial
- (2017) Yoshio Hirayasu et al. Psychiatry Investigation
- Dopamine serotonin stabilizer RP5063: A randomized, double-blind, placebo-controlled multicenter trial of safety and efficacy in exacerbation of schizophrenia or schizoaffective disorder
- (2017) Marc Cantillon et al. SCHIZOPHRENIA RESEARCH
- Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Placebo for Common Psychiatric Disorders Among Children and Adolescents
- (2017) Cosima Locher et al. JAMA Psychiatry
- Use of a Novel Artificial Intelligence Platform on Mobile Devices to Assess Dosing Compliance in a Phase 2 Clinical Trial in Subjects With Schizophrenia
- (2017) Earle E Bain et al. JMIR mHealth and uHealth
- Messages for Clinicians: Moderators and Mediators of Treatment Outcome in Randomized Clinical Trials
- (2016) Helena Chmura Kraemer AMERICAN JOURNAL OF PSYCHIATRY
- Interim evaluation of efficacy or futility in group-sequential trials with multiple co-primary endpoints
- (2016) Koko Asakura et al. BIOMETRICAL JOURNAL
- Efficacy and Safety of Adjunctive Cariprazine in Inadequate Responders to Antidepressants
- (2016) Suresh Durgam et al. JOURNAL OF CLINICAL PSYCHIATRY
- Neuroscience-based Nomenclature (NbN): A call for action
- (2016) Joseph Zohar et al. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
- Statistical controversies in clinical research: scientific and ethical problems with adaptive randomization in comparative clinical trials
- (2015) P. Thall et al. ANNALS OF ONCOLOGY
- Dose timing of d -cycloserine to augment cognitive behavioral therapy for social anxiety: Study design and rationale
- (2015) Stefan G. Hofmann et al. Contemporary Clinical Trials
- A review of the current nomenclature for psychotropic agents and an introduction to the Neuroscience-based Nomenclature
- (2015) Joseph Zohar et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia
- (2015) Jeffrey L. Cummings et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder
- (2015) Terence A. Ketter et al. JOURNAL OF AFFECTIVE DISORDERS
- Randomized Proof of Concept Trial of GLYX-13, an N-Methyl-D-Aspartate Receptor Glycine Site Partial Agonist, in Major Depressive Disorder Nonresponsive to a Previous Antidepressant Agent
- (2015) SHELDON PRESKORN et al. Journal of Psychiatric Practice
- Have Treatment Studies of Depression Become Even Less Generalizable? A Review of the Inclusion and Exclusion Criteria Used in Placebo-Controlled Antidepressant Efficacy Trials Published During the Past 20 Years
- (2015) Mark Zimmerman et al. MAYO CLINIC PROCEEDINGS
- Zonisamide Reduces Withdrawal Symptoms But Does Not Enhance Varenicline-Induced Smoking Cessation
- (2015) Kelly E. Dunn et al. NICOTINE & TOBACCO RESEARCH
- Raloxifene as an Adjunctive Treatment for Postmenopausal Women With Schizophrenia: A 24-Week Double-Blind, Randomized, Parallel, Placebo-Controlled Trial
- (2015) Judith Usall et al. SCHIZOPHRENIA BULLETIN
- The role of regulators, investigators, and patient participants in the rise of the placebo response in major depressive disorder
- (2015) Maurizio Fava World Psychiatry
- Implications of a Biosignature Study of the Placebo Response in Major Depressive Disorder
- (2015) Maurizio Fava JAMA Psychiatry
- Effects of cortisol administration on craving in heroin addicts
- (2015) M Walter et al. Translational Psychiatry
- Treatment Implications of Predominant Polarity and the Polarity Index: A Comprehensive Review
- (2015) A. F. Carvalho et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- A double-blind, placebo-controlled comparator study of LY2140023 monohydrate in patients with schizophrenia
- (2014) AnnCatherine M Downing et al. BMC Psychiatry
- Efficacy and Safety of Adjunctive Armodafinil in Adults With Major Depressive Episodes Associated With Bipolar I Disorder
- (2014) Joseph R. Calabrese et al. JOURNAL OF CLINICAL PSYCHIATRY
- Treatment of Major Depressive Disorder Using Botulinum Toxin A
- (2014) Michelle Magid et al. JOURNAL OF CLINICAL PSYCHIATRY
- Melatonin for prevention of metabolic side-effects of olanzapine in patients with first-episode schizophrenia: Randomized double-blind placebo-controlled study
- (2014) Amirhossein Modabbernia et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Levomilnacipran ER 40 mg and 80 mg in patients with major depressive disorder: a phase III, randomized, double-blind, fixed-dose, placebo-controlled study
- (2014) David Bakish et al. JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- Circadian rhythms in cognitive functioning among patients with schizophrenia: Impact on signal detection in clinical trials of potential pro-cognitive therapies
- (2014) Michael R. Hufford et al. SCHIZOPHRENIA RESEARCH
- Placebo Response in Antipsychotic Clinical Trials
- (2014) Bret R. Rutherford et al. JAMA Psychiatry
- Efficacy of Pharmacotherapy and Psychotherapy for Adult Psychiatric Disorders
- (2014) Maximilian Huhn et al. JAMA Psychiatry
- d-Cycloserine as an Augmentation Strategy With Cognitive-Behavioral Therapy for Social Anxiety Disorder
- (2013) Stefan G. Hofmann et al. AMERICAN JOURNAL OF PSYCHIATRY
- Meta-Regression Analysis of Placebo Response in Antipsychotic Trials, 1970–2010
- (2013) Ofer Agid et al. AMERICAN JOURNAL OF PSYCHIATRY
- The Effects of Subanesthetic Ketamine Infusions on Motivation to Quit and Cue-Induced Craving in Cocaine-Dependent Research Volunteers
- (2013) Elias Dakwar et al. BIOLOGICAL PSYCHIATRY
- SLEEP QUALITY PREDICTS TREATMENT OUTCOME IN CBT FOR SOCIAL ANXIETY DISORDER
- (2013) Alyson K. Zalta et al. DEPRESSION AND ANXIETY
- First Experience With a Wireless System Incorporating Physiologic Assessments and Direct Confirmation of Digital Tablet Ingestions in Ambulatory Patients With Schizophrenia or Bipolar Disorder
- (2013) John M. Kane et al. JOURNAL OF CLINICAL PSYCHIATRY
- d-cycloserine enhancement of exposure therapy for social anxiety disorder depends on the success of exposure sessions
- (2013) Jasper A.J. Smits et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Pomaglumetad methionil: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo
- (2013) Virginia L. Stauffer et al. SCHIZOPHRENIA RESEARCH
- A Novel Approach for Developing and Interpreting Treatment Moderator Profiles in Randomized Clinical Trials
- (2013) Meredith L. Wallace et al. JAMA Psychiatry
- l-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials
- (2012) George I. Papakostas et al. AMERICAN JOURNAL OF PSYCHIATRY
- Rest versus exercise as treatment for patients with low back pain and Modic changes. a randomized controlled clinical trial
- (2012) Rikke K Jensen et al. BMC Medicine
- Adaptive Randomization for Clinical Trials
- (2012) William F. Rosenberger et al. Journal of Biopharmaceutical Statistics
- A 12-Week, Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Comparison Trial of Ziprasidone as Monotherapy for Major Depressive Disorder
- (2012) George I. Papakostas et al. JOURNAL OF CLINICAL PSYCHIATRY
- Correlation Between Different Levels of Placebo Response Rate and Clinical Trial Outcome in Major Depressive Disorder
- (2012) Nadia Iovieno et al. JOURNAL OF CLINICAL PSYCHIATRY
- Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study
- (2012) Michael C Mithoefer et al. JOURNAL OF PSYCHOPHARMACOLOGY
- A randomized, controlled pilot study of MDMA (±3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)
- (2012) Peter Oehen et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Dialogues on Diversifying Clinical Trials: Successful Strategies for Engaging Women and Minorities in Clinical Trials
- (2012) Meghan Coakley et al. JOURNAL OF WOMENS HEALTH
- Pioglitazone Adjunctive Therapy for Moderate-to-Severe Major Depressive Disorder: Randomized Double-Blind Placebo-Controlled Trial
- (2012) Khatereh Sepanjnia et al. NEUROPSYCHOPHARMACOLOGY
- Potential of adaptive clinical trial designs in pharmacogenetic research
- (2012) Frederieke H van der Baan et al. PHARMACOGENOMICS
- A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy among Depressed Outpatients with Inadequate Response to Prior Antidepressant Therapy (ADAPT-A Study)
- (2012) Maurizio Fava et al. PSYCHOTHERAPY AND PSYCHOSOMATICS
- Adaptive trial designs: a review of barriers and opportunities
- (2012) John A Kairalla et al. Trials
- Antipsychotics in anxiety disorders: An oxymoron or a reflection of non-adequate nomenclature?
- (2011) Joseph Zohar et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- How to assess the clinical impact of treatments on patients, rather than the statistical impact of treatments on measures
- (2011) Helena Chmura Kraemer et al. INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
- Evolution of Psychopharmacology Trial Design and Analysis
- (2011) Andrew C. Leon JOURNAL OF CLINICAL PSYCHIATRY
- Optimality, sample size, and power calculations for the sequential parallel comparison design
- (2011) Anastasia Ivanova et al. STATISTICS IN MEDICINE
- Efficiency Perspectives on Adaptive Designs in Stroke Clinical Trials
- (2011) Ken Cheung et al. STROKE
- The use of videoconferencing with patients with psychosis: a review of the literature
- (2011) Ian R Sharp et al. Annals of General Psychiatry
- Evaluation of Comparative Treatment Trials
- (2010) Helena Chmura Kraemer et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Antidepressant Drug Effects and Depression Severity
- (2010) Jay C. Fournier et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Placebo-Controlled, Antidepressant Clinical Trials Cannot Be Shortened to Less Than 4 Weeks’ Duration
- (2010) Enrico Tedeschini et al. JOURNAL OF CLINICAL PSYCHIATRY
- The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study
- (2010) Michael C Mithoefer et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Seamless phase II/III designs
- (2010) Nigel Stallard et al. STATISTICAL METHODS IN MEDICAL RESEARCH
- Sample size re-estimation in clinical trials
- (2009) Michael A. Proschan BIOMETRICAL JOURNAL
- Dose Escalation Methods in Phase I Cancer Clinical Trials
- (2009) Christophe Le Tourneau et al. JNCI-Journal of the National Cancer Institute
- Group Sequential and Adaptive Designs - A Review of Basic Concepts and Points of Discussion
- (2008) Marc Vandemeulebroecke BIOMETRICAL JOURNAL
- New Evidence Regarding Racial And Ethnic Disparities In Mental Health: Policy Implications
- (2008) Thomas G. McGuire et al. HEALTH AFFAIRS
- Use of Remote Centralized Raters Via Live 2-Way Video in a Multicenter Clinical Trial for Schizophrenia
- (2008) Joan Shen et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- What Is Causing the Reduced Drug-Placebo Difference in Recent Schizophrenia Clinical Trials and What Can be Done About It?
- (2008) A. S. Kemp et al. SCHIZOPHRENIA BULLETIN
- Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration
- (2008) Irving Kirsch et al. PLOS MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation