Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis
Authors
Keywords
-
Journal
Expert Opinion On Drug Safety
Volume -, Issue -, Pages 1-14
Publisher
Informa UK Limited
Online
2022-03-02
DOI
10.1080/14740338.2022.2047928
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Comments to Drs. Bahji, Vazquez, and Zarate
- (2021) Wayne C. Drevets et al. JOURNAL OF AFFECTIVE DISORDERS
- Letter to the Editor - Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis
- (2021) Breno Souza-Marques et al. JOURNAL OF AFFECTIVE DISORDERS
- Ketamine for bipolar depression: a systematic review
- (2021) Anees Bahji et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
- (2021) Jordi Bonaventura et al. MOLECULAR PSYCHIATRY
- Letter to the Editor: Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis
- (2021) Joakim Ekstrand JOURNAL OF AFFECTIVE DISORDERS
- Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium
- (2021) Gustavo H. Vázquez et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Intravenous arketamine for treatment-resistant depression: open-label pilot study
- (2020) Gustavo C. Leal et al. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
- Adjunctive intranasal esketamine for major depressive disorder: A systematic review of randomized double-blind controlled-placebo studies
- (2020) Wei Zheng et al. JOURNAL OF AFFECTIVE DISORDERS
- A historical review of antidepressant effects of ketamine and its enantiomers
- (2020) Yan Wei et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Comparative efficacy and tolerability of pharmacological treatments for the treatment of acute bipolar depression: A systematic review and network meta-analysis
- (2020) Anees Bahji et al. JOURNAL OF AFFECTIVE DISORDERS
- Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine
- (2020) Kenji Hashimoto BIOCHEMICAL PHARMACOLOGY
- Treatment Response of Add-On Esketamine Nasal Spray in Resistant Major Depression in Relation to Add-On Second-Generation Antipsychotic Treatment
- (2020) Markus Dold et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients With Major Depressive Disorder Who Have Active Suicide Ideation With Intent: Results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II)
- (2020) Dawn F Ionescu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis
- (2020) Anees Bahji et al. JOURNAL OF AFFECTIVE DISORDERS
- Erratum to “Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis” [Journal of Affective Disorders 278C (2021) 542–555]
- (2020) Anees Bahji et al. JOURNAL OF AFFECTIVE DISORDERS
- Response to commentary on the comparative efficacy of esketamine vs. ketamine meta-analysis: Putting the cart before the horse?
- (2020) Anees Bahji et al. JOURNAL OF AFFECTIVE DISORDERS
- The acute antisuicidal effects of single-dose intravenous ketamine and intranasal esketamine in individuals with major depression and bipolar disorders: A systematic review and meta-analysis
- (2020) Jiaqi Xiong et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial
- (2019) Jennifer L. Phillips et al. AMERICAN JOURNAL OF PSYCHIATRY
- Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study
- (2019) Vanina Popova et al. AMERICAN JOURNAL OF PSYCHIATRY
- ( R )‐Ketamine exerts antidepressant actions partly via conversion to ( 2R,6R )‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses
- (2019) Panos Zanos et al. BRITISH JOURNAL OF PHARMACOLOGY
- Adjunctive ketamine and electroconvulsive therapy for major depressive disorder: A meta-analysis of randomized controlled trials
- (2019) Wei Zheng et al. JOURNAL OF AFFECTIVE DISORDERS
- Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)
- (2019) Maggie Fedgchin et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis
- (2019) Fiona Charlson et al. LANCET
- Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective
- (2019) Kenji Hashimoto PSYCHIATRY AND CLINICAL NEUROSCIENCES
- Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo–control study
- (2019) Mu-Hong Chen et al. NEUROPSYCHOPHARMACOLOGY
- Ketamine and depression: a narrative review
- (2019) Alexandrine Corriger et al. Drug Design Development and Therapy
- Efficacy and Safety of Esketamine Nasal Spray Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression—TRANSFORM-3
- (2019) Rachel Ochs-Ross et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials
- (2019) Katrina Witt et al. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
- Ketamine for acute suicidal ideation. An emergency department intervention: A randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial
- (2019) Yoav Domany et al. DEPRESSION AND ANXIETY
- Defining treatment‐resistant depression
- (2019) Bradley N. Gaynes et al. DEPRESSION AND ANXIETY
- Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study
- (2019) Fernanda S. Correia-Melo et al. JOURNAL OF AFFECTIVE DISORDERS
- Effects of Ketamine Anesthesia on Efficacy, Tolerability, Seizure Response, and Neurocognitive Outcomes in Electroconvulsive Therapy
- (2019) Nicholas J. Ainsworth et al. JOURNAL OF ECT
- Intermittent administration of low dose ketamine can shorten the course of electroconvulsive therapy for depression and reduce complications: A randomized controlled trial
- (2019) Jun Dong et al. PSYCHIATRY RESEARCH
- Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial
- (2018) Michael F. Grunebaum et al. AMERICAN JOURNAL OF PSYCHIATRY
- The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis
- (2018) Samuel T. Wilkinson et al. AMERICAN JOURNAL OF PSYCHIATRY
- Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study
- (2018) Carla M. Canuso et al. AMERICAN JOURNAL OF PSYCHIATRY
- Default Mode Connectivity in Major Depressive Disorder Measured Up to 10 Days After Ketamine Administration
- (2018) Jennifer W. Evans et al. BIOLOGICAL PSYCHIATRY
- Ketamine-based anesthesia improves electroconvulsive therapy outcomes: a randomized-controlled study
- (2018) Jonathan J. Gamble et al. Canadian Journal of Anesthesia-Journal canadien d anesthesie
- Convergent Mechanisms Underlying Rapid Antidepressant Action
- (2018) Panos Zanos et al. CNS DRUGS
- Does oral administration of ketamine accelerate response to treatment in major depressive disorder? Results of a double-blind controlled trial
- (2018) Somaye Arabzadeh et al. JOURNAL OF AFFECTIVE DISORDERS
- A randomized clinical trial of adjunctive ketamine anesthesia in electro-convulsive therapy for depression
- (2018) Minling Zhang et al. JOURNAL OF AFFECTIVE DISORDERS
- Repeated intranasal ketamine for treatment-resistant depression – the way to go? Results from a pilot randomised controlled trial
- (2018) Verònica Gálvez et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
- (2018) Allison C. Nugent et al. MOLECULAR PSYCHIATRY
- Mechanisms of ketamine action as an antidepressant
- (2018) P Zanos et al. MOLECULAR PSYCHIATRY
- Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
- (2018) Panos Zanos et al. PHARMACOLOGICAL REVIEWS
- Predictors of Response to Ketamine in Treatment Resistant Major Depressive Disorder and Bipolar Disorder
- (2018) Carola Rong et al. International Journal of Environmental Research and Public Health
- Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression
- (2018) Ella J. Daly et al. JAMA Psychiatry
- Repeated oral ketamine for out-patient treatment of resistant depression: randomised, double-blind, placebo-controlled, proof-of-concept study
- (2018) Yoav Domany et al. BRITISH JOURNAL OF PSYCHIATRY
- Cognitive function of patients with treatment-resistant depression after a single low dose of ketamine infusion
- (2018) Mu-Hong Chen et al. JOURNAL OF AFFECTIVE DISORDERS
- Repeat-Dose Ketamine Augmentation for Treatment-Resistant Depression with Chronic Suicidal Ideation: A Randomized, Double Blind, Placebo Controlled Trial
- (2018) Dawn F. Ionescu et al. JOURNAL OF AFFECTIVE DISORDERS
- An update on ketamine and its two enantiomers as rapid-acting antidepressants
- (2018) Kai Zhang et al. Expert Review of Neurotherapeutics
- Reducing the global burden of depression: a Lancet–World Psychiatric Association Commission
- (2018) Helen Herrman et al. LANCET
- Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)
- (2018) Maurizio Fava et al. MOLECULAR PSYCHIATRY
- Identifying Ketamine Responses in Treatment-Resistant Depression Using a Wearable Forehead EEG
- (2018) Zehong Cao et al. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
- Administration of ketamine for unipolar and bipolar depression
- (2017) Christoph Kraus et al. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
- What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities
- (2017) S. E. Strasburger et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- A Randomized Pilot Study Comparing Ketamine and Methohexital Anesthesia for Electroconvulsive Therapy in Patients With Depression
- (2017) Shona L. Ray-Griffith et al. JOURNAL OF ECT
- Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy—A Randomized, Double-Blind, Controlled Clinical Study
- (2017) Qibin Chen et al. JOURNAL OF ECT
- Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism
- (2017) Lily R. Aleksandrova et al. JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression
- (2017) Tung-Ping Su et al. NEUROPSYCHOPHARMACOLOGY
- Comparison of the effect of intravenous anesthetics used for anesthesia during electroconvulsive therapy for the hemodynamic safety and the course of ECT.
- (2017) Rafał Wojdacz et al. Psychiatria Polska
- Eficacia y seguridad de la ketamina en depresión bipolar: una revisión sistemática
- (2017) Susana Alberich et al. Revista de Psiquiatria y Salud Mental
- Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression
- (2016) C. K. Loo et al. ACTA PSYCHIATRICA SCANDINAVICA
- A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression
- (2016) Jaskaran B. Singh et al. AMERICAN JOURNAL OF PSYCHIATRY
- Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study
- (2016) Jaskaran B. Singh et al. BIOLOGICAL PSYCHIATRY
- KETAMINE FOR TREATMENT-RESISTANT UNIPOLAR AND BIPOLAR MAJOR DEPRESSION: CRITICAL REVIEW AND IMPLICATIONS FOR CLINICAL PRACTICE
- (2016) William V. Bobo et al. DEPRESSION AND ANXIETY
- Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate
- (2016) Darragh Downey et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- The effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: A randomized controlled study
- (2016) Cheng-Ta Li et al. HUMAN BRAIN MAPPING
- Mood and neuropsychological effects of different doses of ketamine in electroconvulsive therapy for treatment-resistant depression
- (2016) Xiaomei Zhong et al. JOURNAL OF AFFECTIVE DISORDERS
- Ketamine: NMDA Receptors and Beyond
- (2016) C. F. Zorumski et al. JOURNAL OF NEUROSCIENCE
- A Double-Blinded, Randomized, Placebo-Controlled Sub-Dissociative Dose Ketamine Pilot Study in the Treatment of Acute Depression and Suicidality in a Military Emergency Department Setting
- (2016) John Burger et al. MILITARY MEDICINE
- NMDAR inhibition-independent antidepressant actions of ketamine metabolites
- (2016) Panos Zanos et al. NATURE
- Temporal Dynamics of Antidepressant Ketamine Effects on Glutamine Cycling Follow Regional Fingerprints of AMPA and NMDA Receptor Densities
- (2016) Meng Li et al. NEUROPSYCHOPHARMACOLOGY
- Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression
- (2015) D. Jeffrey Newport et al. AMERICAN JOURNAL OF PSYCHIATRY
- Ketamine as a novel treatment for major depressive disorder and bipolar depression: a systematic review and quantitative meta-analysis
- (2015) Ellen E. Lee et al. GENERAL HOSPITAL PSYCHIATRY
- Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression
- (2015) Robin Ortiz et al. JOURNAL OF AFFECTIVE DISORDERS
- A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: Efficacy and tolerability
- (2015) Alexander McGirr et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Meta-analysis of short- and mid-term efficacy of ketamine in unipolar and bipolar depression
- (2015) Bruno Romeo et al. PSYCHIATRY RESEARCH
- Single i.v. ketamine augmentation of newly initiated escitalopram for major depression: results from a randomized, placebo-controlled 4-week study
- (2015) Y.-D. Hu et al. PSYCHOLOGICAL MEDICINE
- Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial
- (2015) J. W. Murrough et al. PSYCHOLOGICAL MEDICINE
- A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder
- (2014) Kyle A.B. Lapidus et al. BIOLOGICAL PSYCHIATRY
- A single infusion of ketamine improves depression scores in patients with anxious bipolar depression
- (2014) Dawn F Ionescu et al. BIPOLAR DISORDERS
- A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks
- (2014) A Villaseñor et al. BRITISH JOURNAL OF PHARMACOLOGY
- Rationale and design of a multicenter randomized clinical trial with memantine and dextromethorphan in ketamine-responder patients
- (2014) Gisèle Pickering et al. Contemporary Clinical Trials
- A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes
- (2014) A. McGirr et al. PSYCHOLOGICAL MEDICINE
- Ketamine administration in depressive disorders: a systematic review and meta-analysis
- (2014) Guillaume Fond et al. PSYCHOPHARMACOLOGY
- Pilot dose–response trial of i.v. ketamine in treatment-resistant depression
- (2014) Rosalyn Lai et al. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
- Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
- (2013) James W. Murrough et al. AMERICAN JOURNAL OF PSYCHIATRY
- Prevalence of treatment-resistant depression in primary care: cross-sectional data
- (2013) Laura Thomas et al. BRITISH JOURNAL OF GENERAL PRACTICE
- Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)
- (2013) Georges Mion et al. CNS Neuroscience & Therapeutics
- Rapid Antidepressant Effect of Ketamine in the Electroconvulsive Therapy Setting
- (2013) Chadi G. Abdallah et al. JOURNAL OF ECT
- Effects of Propofol and Ketamine as Combined Anesthesia for Electroconvulsive Therapy in Patients With Depressive Disorder
- (2013) Xiaobin Wang et al. JOURNAL OF ECT
- Effects of S-Ketamine as an Anesthetic Adjuvant to Propofol on Treatment Response to Electroconvulsive Therapy in Treatment-Resistant Depression
- (2013) Kaija Järventausta et al. JOURNAL OF ECT
- Comparing Effects of Ketamine and Thiopental Administration During Electroconvulsive Therapy in Patients With Major Depressive Disorder
- (2013) Abolghasem Yoosefi et al. JOURNAL OF ECT
- Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
- (2013) G Sanacora et al. MOLECULAR PSYCHIATRY
- Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder
- (2013) Mehdi Ghasemi et al. PSYCHIATRY RESEARCH
- A randomized comparison of ketamine versus methohexital anesthesia in electroconvulsive therapy
- (2013) Keith G. Rasmussen et al. PSYCHIATRY RESEARCH
- Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- Evidence-based treatment strategies for treatment-resistant bipolar depression: a systematic review
- (2012) Pascal Sienaert et al. BIPOLAR DISORDERS
- Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression
- (2012) Xiaochen Zhao et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Course of Improvement in Depressive Symptoms to a Single Intravenous Infusion of Ketamine vs Add-on Riluzole: Results from a 4-Week, Double-Blind, Placebo-Controlled Study
- (2012) Lobna Ibrahim et al. NEUROPSYCHOPHARMACOLOGY
- A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
- (2010) Nancy Diazgranados et al. ARCHIVES OF GENERAL PSYCHIATRY
- Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
- (2009) Sanjay J. Mathew et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
- (2009) Alessandro Liberati et al. PLOS MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now