Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for “on-demand” use and long-term cultures

The Challenge of Long-Term Cultivation of Human Precision-Cut Lung Slices

(2021) Eike B. Preuß et al.   AMERICAN JOURNAL OF PATHOLOGY

Applications and Approaches for 3D Precision-cut Lung Slices: Disease Modeling and Drug Discovery

(2020) Hani N Alsafadi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Isolation of high-yield and -quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts

(2020) John Stegmayr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modeling pneumonic plague in human precision-cut lung slices highlights a role for the plasminogen activating protease in facilitating type 3 secretion

(2019) Srijon K. Banerjee et al.   INFECTION AND IMMUNITY

Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis

(2019) Matea Cedilak et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Biomimetic human lung-on-a-chip for modeling disease investigation

(2019) Kaiyan Li et al.   Biomicrofluidics

Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended ex vivo Culture

(2019) Kolene E. Bailey et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

(2019) Lloyd Tanner et al.   Journal of Innate Immunity

The 3Rs and Humane Experimental Technique: Implementing Change

(2019) Hubrecht et al.   Animals

Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report

(2018) Amy J. Clippinger et al.   TOXICOLOGY IN VITRO

Use of 3D organoids and lung-on-a-chip methods to study lung development, regeneration and disease

(2018) Konstantinos Gkatzis et al.   EUROPEAN RESPIRATORY JOURNAL

Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

(2017) Vanessa Neuhaus et al.   Journal of Occupational Medicine and Toxicology

Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking. A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists

(2016) Yan Bai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Formaldehyde Induces Rho-Associated Kinase Activity to Evoke Airway Hyperresponsiveness

(2016) Joseph Jude et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evaluation of inflammatory and immune responses in long-term cultured human precision-cut lung slices

(2016) Angela Temann et al.   Human Vaccines & Immunotherapeutics

Studying human respiratory disease in animals - role of induced and naturally occurring models

(2015) Kurt Williams et al.   JOURNAL OF PATHOLOGY

Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS)

(2014) L. Lauenstein et al.   TOXICOLOGY IN VITRO

Functional Testing of an Inhalable Nanoparticle Based Influenza Vaccine Using a Human Precision Cut Lung Slice Technique

(2013) Vanessa Neuhaus et al.   PLoS One

Evaluation of fibrosis in precision-cut tissue slices

(2012) I. M. Westra et al.   XENOBIOTICA

Assessment of immunotoxicity using precision-cut tissue slices

(2012) Katherina Sewald et al.   XENOBIOTICA

Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies

(2012) Jean-Paul Morin et al.   XENOBIOTICA

Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices

(2010) S. Switalla et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ex vivo testing of immune responses in precision-cut lung slices

(2008) M. Henjakovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY