Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser

Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease

(2022) Meredith N Frazier et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

(2021) Monica C. Pillon et al.   Nature Communications

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication

(2021) Bo Gao et al.   PLoS Pathogens

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

(2021) Youngchang Kim et al.   Communications Biology

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

(2021) Berta Canal et al.   BIOCHEMICAL JOURNAL

An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

(2021) Jason K. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Antiviral Immune Evasion of SARS-CoV-2

(2021) Daniel K Beyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U

(2021) Meredith N Frazier et al.   NUCLEIC ACIDS RESEARCH

Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography

(2021) Suraj Pandey et al.   IUCrJ

Co-flow injection for serial crystallography at X-ray free-electron lasers

(2021) Diandra Doppler et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

(2020) Matthew Hackbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV ‐2

(2020) Youngchang Kim et al.   PROTEIN SCIENCE

An ancient evolutionary connection between Ribonuclease A and EndoU families

(2020) Arcady Mushegian et al.   RNA

The ePix10k 2-megapixel hard X-ray detector at LCLS

(2020) Tim Brandt van Driel et al.   JOURNAL OF SYNCHROTRON RADIATION

3D printing of gas-dynamic virtual nozzles and optical characterization of high-speed microjets

(2020) Reza Nazari et al.   OPTICS EXPRESS

Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase

(2019) Izumi Ishigami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XGANDALF – extended gradient descent algorithm for lattice finding

(2019) Yaroslav Gevorkov et al.   Acta Crystallographica A-Foundation and Advances

Time-resolved serial femtosecond crystallography at the European XFEL

(2019) Suraj Pandey et al.   NATURE METHODS

Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography

(2018) Jose L. Olmos et al.   BMC BIOLOGY

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

(2017) J. R. Stagno et al.   NATURE

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

(2017) Xufang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

(2017) Eveline Kindler et al.   PLoS Pathogens

Polder maps: improving OMIT maps by excluding bulk solvent

(2017) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

OnDA: online data analysis and feedback for serial X-ray imaging

(2016) Valerio Mariani et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Structural enzymology using X-ray free electron lasers

(2016) Christopher Kupitz et al.   Structural Dynamics

ThePDB_REDOserver for macromolecular structure model optimization

(2014) Robbie P. Joosten et al.   IUCrJ

MAP_CHANNELS: a computation tool to aid in the visualization and characterization of solvent channels in macromolecular crystals

(2014) Douglas H. Juers et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Cheetah: software for high-throughput reduction and analysis of serial femtosecond X-ray diffraction data

(2014) Anton Barty et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Autoindexing diffraction images withiMosflm

(2013) Harold R. Powell et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Serial Femtosecond Crystallography of G Protein-Coupled Receptors

(2013) W. Liu et al.   SCIENCE

Mix and Inject: Reaction Initiation by Diffusion for Time-Resolved Macromolecular Crystallography

(2013) Marius Schmidt   Advances in Condensed Matter Physics

Breaking the indexing ambiguity in serial crystallography

(2013) Wolfgang Brehm et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

CrystFEL: a software suite for snapshot serial crystallography

(2012) Thomas A. White et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Toward structure determination using membrane–protein nanocrystals and microcrystals

(2011) Mark S. Hunter et al.   METHODS

Femtosecond X-ray protein nanocrystallography

(2011) Henry N. Chapman et al.   NATURE

Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements

(2011) Anton Barty et al.   Nature Photonics

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Gas dynamic virtual nozzle for generation of microscopic droplet streams

(2008) D P DePonte et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS