Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models

Activation of the Notch1-c-myc-VCAM1 signalling axis initiates liver progenitor cell-driven hepatocarcinogenesis and pulmonary metastasis

(2022) Wen-Rui Wu et al.   ONCOGENE

OTUD1 Activates Caspase‐Independent and Caspase‐Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation

(2021) Qingyu Luo et al.   Advanced Science

A circular network of coregulated sphingolipids dictates lung cancer growth and progression

(2021) Qiong Meng et al.   EBioMedicine

A phase II study of the combination chemotherapy of bevacizumab and gemcitabine in women with platinum-resistant recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer

(2020) Shoji Nagao et al.   Journal of Ovarian Research

Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo

(2020) Sören Reinke et al.   Cell Reports

Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

(2020) Ping-Pui Wong et al.   CELL

Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study

(2020) Jorge E. Cortes et al.   LEUKEMIA

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

(2020) Cheng Zeng et al.   Redox Biology

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

(2020) Danping Zheng et al.   Cell Discovery

Pan-cancer analysis of NLRP3 inflammasome with potential implications in prognosis and immunotherapy in human cancer

(2020) Mingyi Ju et al.   BRIEFINGS IN BIOINFORMATICS

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

(2020) Eun Hee Koh et al.   GUT

Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110

(2020) Yitian Chen et al.   CANCER LETTERS

Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data

(2019) Sili Fan et al.   ANALYTICAL CHEMISTRY

Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma

(2019) Lu-yang Zhang et al.   Frontiers in Oncology

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Chemotherapeutic agents for the treatment of metastatic breast cancer: An update

(2018) Mariam Abotaleb et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of the NLRP3 inflammasome in cancer

(2018) Maryam Moossavi et al.   Molecular Cancer

Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial

(2017) John P Neoptolemos et al.   LANCET

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

(2015) Ping-Pui Wong et al.   CANCER CELL

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma

(2015) Catherine Westbom et al.   PLoS One

Over 10 000 Peptide Identifications from the HeLa Proteome by Using Single-Shot Capillary Zone Electrophoresis Combined with Tandem Mass Spectrometry

(2014) Liangliang Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Integrin control of the transforming growth factor-β pathway in glioblastoma

(2013) Patrick Roth et al.   BRAIN

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Overexpression of Integrin β5 Enhances the Paracrine Properties of Circulating Angiogenic Cells via Src Kinase–Mediated Activation of STAT3

(2010) Maren Leifheit-Nestler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ceramide Regulates Gemcitabine-Induced Senescence and Apoptosis in Human Pancreatic Cancer Cell Lines

(2009) D. E. Modrak et al.   MOLECULAR CANCER RESEARCH

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein

(2009) M R Abedini et al.   ONCOGENE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY