Valproic Acid Attenuated PTZ-induced Oxidative Stress, Inflammation, and Apoptosis in the SH-SY5Y Cells via Modulating the TRPM2 Channel

A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol

(2022) Mustafa Nazıroğlu   METABOLIC BRAIN DISEASE

Nesfatin-1 ameliorates oxidative brain damage and memory impairment in rats induced with a single acute epileptic seizure

(2022) Sevil Arabacı Tamer et al.   LIFE SCIENCES

Rhoifolin attenuates damage to hippocampal neuronal culture model of acquired epilepsy in vitro by regulating NF-κB/iNOS/COX-2 axis

(2022) Huizhen Qi et al.   Quality Assurance and Safety of Crops & Foods

The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line

(2021) Ahmet Sevki Taskiran et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Interferon Gamma-Mediated Oxidative Stress Induces Apoptosis, Neuroinflammation, Zinc Ion Influx, and TRPM2 Channel Activation in Neuronal Cell Line: Modulator Role of Curcumin

(2021) Mustafa Güzel et al.   INFLAMMATION

Neuroprotective Effect of Fisetin Through Suppression of IL-1R/TLR Axis and Apoptosis in Pentylenetetrazole-Induced Kindling in Mice

(2021) Saima Khatoon et al.   Frontiers in Neurology

Protective role of selenium on MPP+ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells

(2021) Kenan Yıldızhan et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Selenium and neurological diseases: Focus on peripheral pain and TRP channels

(2020) Mustafa Nazıroğlu et al.   Current Neuropharmacology

Ellagic acid attenuates liver toxicity induced by valproic acid in rats

(2020) Noha F. Abdelkader et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Curcumin diminishes cisplatin-induced apoptosis and mitochondrial oxidative stress through inhibition of TRPM2 channel signaling pathway in mouse optic nerve

(2020) Dilek Özkaya et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

(2020) Alaa Alachkar et al.   MOLECULES

Effect of valproic acid on oxidative stress parameters of glutamate‑induced excitotoxicity in SH‑SY5Y cells

(2020) Berna Bebi̇toğlu et al.   Experimental and Therapeutic Medicine

Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel

(2020) Yener Akyuva et al.   Scientific Reports

Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia

(2020) Kenan Yıldızhan et al.   MOLECULAR NEUROBIOLOGY

The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line

(2020) Ahmet Sevki Taskiran et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy

(2020) Hui Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective role of chrysin‐loaded poly(lactic‐co‐glycolic acid) nanoparticle against kindling‐induced epilepsy through Nrf2/ARE/HO‐1 pathway

(2020) Ying Zhang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

TRPM2 channel-mediated cell death: an important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions

(2020) Philippa Malko et al.   Redox Biology

The effects of salmon calcitonin on epileptic seizures, epileptogenesis, and postseizure hippocampal neuronal damage in pentylenetetrazole-induced epilepsy model in rats

(2020) Ahmet Sevki Taskıran et al.   EPILEPSY & BEHAVIOR

Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death

(2019) Xinfang An et al.   Cells

Long non-coding RNA-p21 regulates MPP+-induced neuronal injury by targeting miR-625 and derepressing TRPM2 in SH-SY5Y cells

(2019) Xiu-Ming Ding et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice

(2019) Qianqian Zheng et al.   BRAIN RESEARCH BULLETIN

Oxidative stress in epilepsy

(2018) Ursula Geronzi et al.   Expert Review of Neurotherapeutics

Neuropathological profile of the pentylenetetrazol (PTZ) kindling model

(2018) E. Samokhina et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Oxidative stress in epilepsy

(2018) Ursula Geronzi et al.   Expert Review of Neurotherapeutics

Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction

(2018) Ashif Iqubal et al.   LIFE SCIENCES

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences

(2018) Michele Romoli et al.   Current Neuropharmacology

Metabolic Dysfunction and Oxidative Stress in Epilepsy

(2017) Jennifer Pearson-Smith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy

(2017) Parichehr Hassanzadeh et al.   LIFE SCIENCES

Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca2+ Entry Through TRPM2 and TRPV1 Channels in Dorsal Root Ganglion and Hippocampus of Diabetic Rats by Melatonin and Selenium

(2016) Mehmet Cemal Kahya et al.   MOLECULAR NEUROBIOLOGY

Epilepsy: new advances

(2015) Solomon L Moshé et al.   LANCET

Melatonin modulates apoptosis and TRPM2 channels in transfected cells activated by oxidative stress

(2012) Ömer Çelik et al.   PHYSIOLOGY & BEHAVIOR

A Calcium Influx Pathway Regulated Separately by Oxidative Stress and ADP-Ribose in TRPM2 Channels: Single Channel Events

(2008) Mustafa Nazıroğlu et al.   NEUROCHEMICAL RESEARCH