Protein structure prediction has reached the single-structure frontier

Structural biology is solved — now what?

(2022) Abbas Ourmazd et al.   NATURE METHODS

The impact of AlphaFold2 one year on

(2022) David T. Jones et al.   NATURE METHODS

The protein-folding problem: Not yet solved

(2022) Peter B. Moore et al.   SCIENCE

AlphaFold2 fails to predict protein fold switching

(2022) Devlina Chakravarty et al.   PROTEIN SCIENCE

Ligand binding remodels protein side-chain conformational heterogeneity

(2022) Stephanie A Wankowicz et al.   eLife

Whither structural biologists?

(2022) Gerard J. Kleywegt et al.   IUCrJ

CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks

(2021) Ellen D. Zhong et al.   NATURE METHODS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

AlphaFold2 and the future of structural biology

(2021) Patrick Cramer   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Advances and challenges in time-resolved macromolecular crystallography

(2021) Gisela Brändén et al.   SCIENCE

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

Retrieving functional pathways of biomolecules from single-particle snapshots

(2020) Ali Dashti et al.   Nature Communications

New Look at Hemoglobin Allostery

(2015) Yue Yuan et al.   CHEMICAL REVIEWS

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

(2015) Daniel A Keedy et al.   eLife

lDDT: a local superposition-free score for comparing protein structures and models using distance difference tests

(2013) Valerio Mariani et al.   BIOINFORMATICS

Radiation damage in macromolecular crystallography: what is it and why should we care?

(2010) Elspeth F. Garman   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE