Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

High-temperature and high-resolution crystallography of thermostable copper nitrite reductase

(2015) Yohta Fukuda et al.   CHEMICAL COMMUNICATIONS

Integrative, dynamic structural biology at atomic resolution—it's about time

(2015) Henry van den Bedem et al.   NATURE METHODS

Direct observation of hierarchical protein dynamics

(2015) J. R. Lewandowski et al.   SCIENCE

Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins

(2015) Giorgio Schirò et al.   Nature Communications

Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit

(2015) Daniel A. Keedy et al.   PLoS Computational Biology

Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

(2015) Monarin Uervirojnangkoorn et al.   eLife

Population Shuffling of Protein Conformations

(2014) Colin A. Smith et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

E pluribus unum, no more: from one crystal, many conformations

(2014) Rahel A Woldeyes et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Photosynthetic complex in close-up

(2014) Ilme Schlichting   NATURE

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Native structure of photosystem II at 1.95 Å resolution viewed by femtosecond X-ray pulses

(2014) Michihiro Suga et al.   NATURE

Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers

(2014) Johan Hattne et al.   NATURE METHODS

Determination of damage-free crystal structure of an X-ray–sensitive protein using an XFEL

(2014) Kunio Hirata et al.   NATURE METHODS

Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR

(2014) R. B. Fenwick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Goniometer-based femtosecond crystallography with X-ray free electron lasers

(2014) Aina E. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR

(2014) Daniel A. Keedy et al.   STRUCTURE

Multiscale Conformational Heterogeneity in Staphylococcal Protein A: Possible Determinant of Functional Plasticity

(2014) Lindsay N. Deis et al.   STRUCTURE

Taking snapshots of photosynthetic water oxidation using femtosecond X-ray diffraction and spectroscopy

(2014) Jan Kern et al.   Nature Communications

Automated identification of functional dynamic contact networks from X-ray crystallography

(2013) Henry van den Bedem et al.   NATURE METHODS

Protein structural ensembles are revealed by redefining X-ray electron density noise

(2013) P. T. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial distribution of radiation damage to crystalline proteins at 25–300 K

(2012) Matthew Warkentin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biomolecular Simulation: A Computational Microscope for Molecular Biology

(2012) Ron O. Dror et al.   Annual Review of Biophysics

Global radiation damage: temperature dependence, time dependence and how to outrun it

(2012) Matthew Warkentin et al.   JOURNAL OF SYNCHROTRON RADIATION

X-ray lasers for structural and dynamic biology

(2012) J C H Spence et al.   REPORTS ON PROGRESS IN PHYSICS

Modelling dynamics in protein crystal structures by ensemble refinement

(2012) B Tom Burnley et al.   eLife

Accessing protein conformational ensembles using room-temperature X-ray crystallography

(2011) J. S. Fraser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation damage in macromolecular crystallography: what is it and why should we care?

(2010) Elspeth F. Garman   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Progress in rational methods of cryoprotection in macromolecular crystallography

(2010) Thomas Alcorn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Automated electron-density sampling reveals widespread conformational polymorphism in proteins

(2010) P. Therese Lang et al.   PROTEIN SCIENCE

Modeling discrete heterogeneity in X-ray diffraction data by fitting multi-conformers

(2009) Henry van den Bedem et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The protein-solvent glass transition

(2009) Wolfgang Doster   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protein Sectors: Evolutionary Units of Three-Dimensional Structure

(2009) Najeeb Halabi et al.   CELL

Slow cooling of protein crystals

(2009) Matthew Warkentin et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

A beginner's guide to radiation damage

(2009) James M. Holton   JOURNAL OF SYNCHROTRON RADIATION

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

NMR spectroscopy brings invisible protein states into focus

(2009) Andrew J Baldwin et al.   Nature Chemical Biology

A unified model of protein dynamics

(2009) H. Frauenfelder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing and controlling the inherent dynamics of cyclophilin-A

(2009) Jennifer Schlegel et al.   PROTEIN SCIENCE