Double blind trial of a deuterated form of linoleic acid (RT001) in Friedreich ataxia

Safety and feasibility of upper limb cardiopulmonary exercise test in Friedreich ataxia

(2021) Chiara Pane et al.   European Journal of Preventive Cardiology

Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 4-year cohort study

(2021) Kathrin Reetz et al.   LANCET NEUROLOGY

RT001 in Progressive Supranuclear Palsy—Clinical and In-Vitro Observations

(2021) Plamena R. Angelova et al.   Antioxidants

Safety and Efficacy of Omaveloxolone in Friedreich's Ataxia ( MOXIe Study)

(2020) David R. Lynch et al.   ANNALS OF NEUROLOGY

Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich’s ataxia

(2020) Liwei Weng et al.   Scientific Reports

ALSUntangled No. 47: RT001

(2019) Richard Bedlack   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Deuterium-reinforced linoleic acid lowers lipid peroxidation and mitigates cognitive impairment in the Q140 knock in mouse model of Huntington's disease

(2018) Asa Hatami et al.   FEBS Journal

Randomized, clinical trial of RT001: Early signals of efficacy in Friedreich's ataxia

(2018) Theresa Zesiewicz et al.   MOVEMENT DISORDERS

Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes

(2018) Lili Guo et al.   Scientific Reports

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia

(2018) David R. Lynch et al.   Annals of Clinical and Translational Neurology

Pharmacological therapeutics in Friedreich ataxia: the present state

(2017) Cassandra Strawser et al.   Expert Review of Neurotherapeutics

Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease

(2017) Ahmed Elharram et al.   FEBS Journal

Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia

(2017) Vijayendran Chandran et al.   eLife

Pharmacological therapeutics in Friedreich ataxia: the present state

(2017) Cassandra Strawser et al.   Expert Review of Neurotherapeutics

Progression of Friedreich ataxia: quantitative characterization over 5 years

(2016) Maya Patel et al.   Annals of Clinical and Translational Neurology

Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress

(2015) Alexander Y. Andreyev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia

(2015) Rosella Abeti et al.   PHARMACOLOGICAL RESEARCH

Stable isotopes and LC–MS for monitoring metabolic disturbances in Friedreich's ataxia platelets

(2015) Andrew J Worth et al.   Bioanalysis

Insights into the role of oxidative stress in the pathology of Friedreich ataxia using peroxidation resistant polyunsaturated fatty acids

(2013) M. Grazia Cotticelli et al.   Redox Biology

Understanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular models

(2012) A. Martelli et al.   Disease Models & Mechanisms

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation

(2012) Shauna Hill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mortality in Friedreich Ataxia

(2011) Amy Y. Tsou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease

(2011) Mikhail S. Shchepinov et al.   TOXICOLOGY LETTERS

Friedreich Ataxia: Molecular Mechanisms, Redox Considerations, and Therapeutic Opportunities

(2010) Renata Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Exercise Capacity and Idebenone Intervention in Children and Adolescents With Friedreich Ataxia

(2010) Bart E. Drinkard et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Does oxidative stress contribute to the pathology of Friedreich’s ataxia? A radical question

(2010) Jeffrey S. Armstrong et al.   FASEB JOURNAL

Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress

(2010) Shauna Hill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemistry and biochemistry of lipid peroxidation products

(2010) F. Guéraud et al.   FREE RADICAL RESEARCH

Measuring the rate of progression in Friedreich ataxia: Implications for clinical trial design

(2010) Lisa S. Friedman et al.   MOVEMENT DISORDERS

Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features

(2008) Lauren M. Myers et al.   MOVEMENT DISORDERS

Regulation of brain polyunsaturated fatty acid uptake and turnover

(2008) Chuck T. Chen et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS