Review
Biochemistry & Molecular Biology
Michael D. Guile, Akash Jain, Kyle A. Anderson, Catherine F. Clarke
Summary: Coenzyme Q (CoQ) is a vital lipid that plays multiple cellular functions, including cellular respiration, antioxidant protection, redox homeostasis, and ferroptosis suppression. Deficiencies in CoQ can be ameliorated by high-dose supplementation, and understanding its uptake and transport can improve clinical use and deficiency treatment. This review summarizes the current knowledge of CoQ uptake and intracellular distribution in yeast, mammalian cell culture, rodent models, and organism level absorption. The literature suggests that CoQ uptake and distribution are complex processes involving the endomembrane system and newly identified lipid transporters, with impairment causing significant effects on metabolism and stress response. Furthermore, significant gaps in our understanding of CoQ distribution within the cell are identified, suggesting future research directions.
Review
Chemistry, Medicinal
Plamena R. Angelova, Noemi Esteras, Andrey Y. Abramov
Summary: With the aging population, neurodegenerative diseases have become a major challenge in modern society, with lipid peroxidation playing a key role in the mechanism of neuronal loss. Research suggests that products of lipid peroxidation can trigger neuronal cell death, providing potential new therapeutic directions for neurodegenerative disorders.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Naig Gueguen, Olivier Baris, Guy Lenaers, Pascal Reynier, Marco Spinazzi
Summary: This article provides an overview of Coenzyme Q (CoQ) distribution in cells and tissues, secondary CoQ deficiency in neurological diseases, and therapeutic strategies for CoQ supplementation. It also discusses improvements in CoQ absorption, formulations, and imaging techniques.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yang Liu, Yuan Wang, Zhi Lin, Rui Kang, Daolin Tang, Jiao Liu
Summary: SLC25A22 acts as a metabolic repressor of ferroptosis by producing glutathione and monounsaturated fatty acids, providing a previously unrecognized defense pathway against ferroptotic cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-ichi Yamada
Summary: This study constructed a library of 465 oxPCs using mass spectrometry and found that doubly oxygenated polyunsaturated fatty acid (PUFA)-PCs are generated in the early phase of acetaminophen-induced acute liver failure.
NATURE COMMUNICATIONS
(2021)
Article
Biology
James Robertson, Andrew Jeffs, Christopher Hedges, Anthony J. R. Hickey
Summary: Isoeugenol, an anaesthetic used in the transportation of live lobsters, acts as a metabolic suppressant, reducing energy expenditure and improving survival rates. This study investigates the impact of isoeugenol on mitochondrial function, with a particular focus on respiration supported by complex I and cytochrome c oxidase. The results demonstrate that isoeugenol inhibits respiration through complex I and indicates it may act as a possible target for isoeugenol's effects.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Catarina M. Quinzii, Luis C. Lopez
Summary: Mitochondrial disorders are genetic diseases with inadequate therapy due to the heterogeneity and tissue-specificity of pathomechanisms. Abnormalities in hydrogen sulfide (H2S) metabolism are emerging as a novel mechanism in mitochondrial dysfunction, but further studies are needed to understand the effects and relevance in mitochondrial diseases. The review focuses on derangement of H2S metabolism in primary Coenzyme Q (CoQ) deficiency and emphasizes the need for more research on the consequences of abnormalities in H2S and GSH synthesis on the oxidation pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nathchar Naowarojna, Tianshu William Wu, Zijian Pan, Mengyu Li, Jingrong Regina Han, Yilong Zou
Summary: Ferroptosis is characterized by the accumulation of polyunsaturated-lipid peroxidation on cellular membranes in an iron-dependent manner. It has been implicated in various pathophysiological processes, but our understanding of its regulation is incomplete.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Manuel Aureliano, Ana Luisa De Sousa-Coelho, Connor C. Dolan, Deborah A. Roess, Debbie C. Crans
Summary: Lipid peroxidation (LPO), induced by exposure to vanadium salts and compounds, is a process that affects human health. The LPO reaction involves the oxidation of alkene bonds in polyunsaturated fatty acids, resulting in the formation of radical and reactive oxygen species (ROS). Vanadium species have both direct and indirect effects on ROS formation, making the study of LPO arising from increased ROS challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Salvatore Nesci, Cristina Algieri, Fabiana Trombetti, Micaela Fabbri, Giorgio Lenaz
Summary: We investigated the aerobic oxidation of NADH and succinate in frozen and thawed swine heart mitochondria. Our results show that the electron fluxes from NADH and succinate are completely independent and do not mix at the level of mobile diffusible components. The difference in flux control coefficient between NADH and succinate oxidation can be attributed to a stronger interaction of cytochrome c with the supercomplex in swine mitochondria.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2023)
Article
Geriatrics & Gerontology
Zuzana Sumbalova, Ol'ga Ulicna, Jarmila Kucharska, Zuzana Rausova, Ol'ga Vancova, L'ubomir Melichercik, Tomas Tvrdik, Marek Nemec, Svatava Kasparova
Summary: This study used rats as experimental animals and found that chronic D-galactose administration led to lower intracellular pH, decreased inorganic phosphate to ATP ratio, and increased phosphocreatine to inorganic phosphate ratio in the brain through in vivo P-31 MRS. These changes indicate a higher index of oxidative phosphorylation and provide evidence of early neurodegeneration.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
Summary: Cancer disrupts lipid metabolism, leading to altered metabolism intermediates and contributing to abnormal growth and metastasis. The shift in lipid metabolism towards an increased presence of polyunsaturated fatty acids (PUFAs) in membrane phospholipids (PLs) also causes resistance to cancer therapy. The vulnerability of cancer cells to lipid peroxidation (LPO) and subsequent ferroptosis, a new form of regulated cell death, depends on adaptive lipidome remodeling, LPO patterns, and LPO scavenging ability. Understanding the molecular basis of altered lipid metabolism in cancer may offer new opportunities for overcoming cancer resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Juan Diego Hernandez-Camacho, Laura Garcia-Corzo, Daniel Jose Moreno Fernandez-Ayala, Placido Navas, Guillermo Lopez-Lluch
Summary: Coenzyme Q is a crucial lipidic molecule essential for maintaining aerobic metabolism, promoting ATP synthesis in mitochondria, exerting antioxidant functions in cellular membranes, regulating cellular redox homeostasis, and controlling various apoptosis mechanisms. Its levels and reactions play important roles in aging, age-associated metabolic disorders, and combating diseases, as well as enhancing physical performance in aging individuals.
Article
Multidisciplinary Sciences
Shiqi Wu, Chao Mao, Lavanya Kondiparthi, Masha V. Poyurovsky, Kellen Olszewski, Boyi Gan
Summary: This study reveals the mechanism of GPD2 in defense against ferroptosis, suppressing mitochondrial ferroptosis by generating ubiquinol. This finding provides a new avenue for targeting ferroptosis in disease treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Mei Hu, Yan Jiang, Jing-Jing Xu
Summary: This study demonstrated that Coq9 plays a critical role in CoQ biosynthesis in plants, and its disruption results in lower CoQ content. These findings provide new insights into the evolution of CoQ biosynthesis in plants.
Article
Clinical Neurology
Stephen Bruehl, Frederic T. Billings, Sara Anderson, Gregory Polkowski, Andrew Shinar, Jonathan Schildcrout, Yaping Shi, Ginger Milne, Anthony Dematteo, Puneet Mishra, R. Norman Harden
Summary: This study evaluated the preoperative predictors of complex regional pain syndrome (CRPS) outcomes following total knee arthroplasty (TKA) at 6 months. The findings suggest that central sensitization and inflammatory mechanisms play a role in CRPS risk after tissue trauma.
Article
Biochemistry & Molecular Biology
Dena Parsa, Luul A. Aden, Ashley Pitzer, Tan Ding, Chang Yu, Andre Diedrich, Ginger L. Milne, Annet Kirabo, Cyndya A. Shibao
Summary: This study confirms the effectiveness of using the AChE inhibitor galantamine to reduce lipid-induced oxidative stress and inflammation in obese African Americans.
MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mengjie Li, Yingya Zhao, Qi Dai, Ginger Milne, Jirong Long, Qiuyin Cai, Qingxia Chen, Xianglan Zhang, Qing Lan, Nathaniel Rothman, Yu-Tang Gao, Xiao-Ou Shu, Wei Zheng, Gong Yang
Summary: This study reveals for the first time that there is an inverse relationship between height and obesity measures and lipid peroxidation, suggesting a shared biological process.
Article
Anesthesiology
Stephen Bruehl, Ginger Milne, Jonathan Schildcrout, Yaping Shi, Sara Anderson, Andrew Shinar, Gregory Polkowski, Puneet Mishra, Frederic T. Billings
Summary: Total knee arthroplasty (TKA) is effective for pain reduction in most patients, but 15% or more report unsatisfactory long-term pain outcomes. Elevated perioperative oxidative stress (OS) seems to exert small but significant adverse effects on long-term post-TKA pain outcomes, although this OS seems unrelated to ischemic reperfusion (IR) injury associated with extended tourniquet use.
Article
Medicine, Research & Experimental
Yvonne L. Latour, Johanna C. Sierra, Jordan L. Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Thaddeus M. Smith, Kara M. McNamara, Paula B. Luis, Claus Schneider, Justin Jacobse, Jeremy A. Goettel, M. Wade Calcutt, Kristie L. Rose, Kevin L. Schey, Ginger L. Milne, Alberto G. Delgado, M. Blanca Piazuelo, Bindu D. Paul, Solomon H. Snyder, Alain P. Gobert, Keith T. Wilson
Summary: Macrophages play a crucial role in the inflammatory response to Helicobacter pylori infection. Induction of cystathionine gamma-lyase (CTH) in macrophages by H. pylori promotes persistent inflammation. CTH deficiency results in altered macrophage function and metabolism, leading to decreased gastric inflammation.
Article
Biochemistry & Molecular Biology
Margaret A. Adgent, Tebeb Gebretsadik, Cordelia R. Elaiho, Ginger L. Milne, Paul Moore, Terryl J. Hartman, Whitney Cowell, Cecilia S. Alcala, Nicole Bush, Robert Davis, Kaja Z. LeWinn, Frances A. Tylavsky, Rosalind J. Wright, Kecia N. Carroll
Summary: Prenatal oxidative stress may be associated with childhood wheeze/asthma in certain populations. Further research is needed to understand underlying mechanisms and racial differences.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Miguel Tillo, William C. Lamanna, Chrissa A. Dwyer, Daniel R. Sandoval, Ariane R. Pessentheiner, Norah Al-Azzam, Stephane Sarrazin, Jon C. Gonzales, Shih-Hsin Kan, Alexander Y. Andreyev, Nicholas Schultheis, Bryan E. Thacker, Charles A. Glass, Patricia I. Dickson, Raymond Y. Wang, Scott B. Selleck, Jeffrey D. Esko, Philip L. S. M. Gordts
Summary: Lysosomal storage diseases result in energy imbalance and metabolic abnormalities in MPS IIIa mice, including hypertriglyceridemia, reduced lipid storage, increased activity of brown adipose tissue (BAT), leading to hyperthermia, increased appetite, increased thirst, and increased energy expenditure. These changes are caused by impaired fusion of autophagosomes and lysosomes, resulting in increased mitochondria content in brown adipose tissue.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Stephanie M. Eick, Sarah Dee Geiger, Akram Alshawabkeh, Max Aung, Emily Barrett, Nicole R. Bush, Jose F. Cordero, Kelly K. Ferguson, John D. Meeker, Ginger L. Milne, Ruby H. N. Nguyen, Amy M. Padula, Sheela Sathyanarayana, Barrett M. Welch, Susan L. Schantz, Tracey J. Woodruff, Rachel Morello-Frosch
Summary: This study examined the predictors of prenatal oxidative stress biomarkers, including biological, behavioral, and social factors, using data from four pregnancy cohorts. The results showed that lower socioeconomic status and psychosocial stress were associated with elevated levels of oxidative stress biomarkers. These findings suggest that oxidative stress may be a pathway linking various factors to adverse pregnancy and child health outcomes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Viktar Abashkin, Elzbieta Pedziwiatr-Werbicka, Katarzyna Horodecka, Victoriya Zhogla, Egor Ulashchik, Vadim Shmanai, Dzmitry Shcharbin, Maria Bryszewska
Summary: The leading cause of death, cancer, necessitates the development of new effective treatment systems, such as genetic therapy using siRNA. This study explores the use of dendronized and PEGylated silver nanoparticles as potential vectors to deliver proapoptotic siRNA (siMCL-1) to target cells. Through various methods, stable siRNA and AgNP complexes were obtained and shown to efficiently deliver siRNAs to tumor cells, resulting in significant cell death due to apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yingya Zhao, Ginger L. Milne, Qingxia Chen, Qi Dai, Xianglan Zhang, Marina S. Nogueira, Hui Cai, Qing Lan, Nathaniel Rothman, Qiuyin Cai, Yu-Tang Gao, Xiao-Ou Shu, Wei Zheng, Gong Yang
Summary: This study prospectively evaluated the association between lipid peroxidation and the incidence of type 2 diabetes (T2D) in a sample of women. The results showed that higher levels of F-2-IsoPs in urine were associated with an increased risk of T2D, especially among women with higher BMI.
FREE RADICAL RESEARCH
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Alexandra Shingina, Xijing Han, Lei Fan, Ginger Milne, Qi Dai, Martha Shrubsole
Article
Endocrinology & Metabolism
Michael P. Murphy, Hulya Bayir, Vsevolod Belousov, Christopher J. Chang, Kelvin J. A. Davies, Michael J. Davies, Tobias P. Dick, Toren Finkel, Henry J. Forman, Yvonne Janssen-Heininger, David Gems, Valerian E. Kagan, Balaraman Kalyanaraman, Nils-Goran Larsson, Ginger L. Milne, Thomas Nystrom, Henrik E. Poulsen, Rafael Radi, Holly Van Remmen, Paul T. Schumacker, Paul J. Thornalley, Shinya Toyokuni, Christine C. Winterbourn, Huiyong Yin, Barry Halliwell
Summary: This article discusses the important roles of reactive oxygen species (ROS) in health and disease, and proposes guidelines and best practices for the nomenclature and assessment of ROS, oxidative reactions, and oxidative damage in cells, tissues, and in vivo.
Meeting Abstract
Oncology
Ginger L. Milne, Robert A. Vierkant, Amy C. Degnim, Anna Maria Storniolo, Jill E. Henry, Laura M. Pacheco-Spann, Derek C. Radisky, Mark E. Sherman
Meeting Abstract
Clinical Neurology
Stephen Bruehl, Frederic T. Billings, Sara Anderson, Gregory Polkowski, Andrew Shinar, Jonathan Schildcrout, Yaping Shi, Ginger Milne, Anthony Dematteo, Puneet Mishra, R. Norman
Meeting Abstract
Oncology
Maeve Kiely, Ginger L. Milne, Tsion Z. Minas, Tiffany H. Dorsey, Wei Tang, Cheryl J. Smith, Francine Baker, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)