Chemistry and biochemistry of lipid peroxidation products

Substrate Specificity Combined with Stereopromiscuity in Glutathione Transferase A4-4-Dependent Metabolism of 4-Hydroxynonenal

(2010) Larissa M. Balogh et al.   BIOCHEMISTRY

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

(2010) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death

(2010) Nikolaus Bresgen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration

(2009) Kurt M. Bertram et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Piceatannol Attenuates 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells by Blocking Activation of c-Jun N-Terminal Kinase

(2009) Young Jin Jang et al.   Annals of the New York Academy of Sciences

Protein Carbonylation

(2009) Yuichiro J. Suzuki et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Alzheimer’s disease and Notch signaling

(2009) Ha-Na Woo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aldo–keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels

(2009) Linlin Zhong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Notch signaling in colorectal cancer

(2009) L. Qiao et al.   CARCINOGENESIS

Identification of Advanced Reaction Products Originating from the Initial 4-Oxo-2-nonenal-cysteine Michael Adducts

(2009) Yuuki Shimozu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ascorbic Acid Promotes Detoxification and Elimination of 4-Hydroxy-2(E)-nonenal in Human Monocytic THP-1 Cells

(2009) Cristobal L. Miranda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

Autophagy in disease: a double-edged sword with therapeutic potential

(2009) Wim Martinet et al.   CLINICAL SCIENCE

Heat Shock Proteins in Diabetes and Wound Healing

(2009) Mustafa Atalay et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Formation and regulation of lipid microdomains in cell membranes: Theory, modeling, and speculation

(2009) Jun Fan et al.   FEBS LETTERS

A 4-oxo-2(E)-nonenal-derived glutathione adduct from 15-lipoxygenase-1-mediated oxidation of cytosolic and esterified arachidonic acid

(2009) Peijuan Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity

(2009) Eun Sun Cho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells

(2009) Lea D. Marchette et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study

(2009) Heather C. Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of RLIP76 in doxorubicin resistance in lung cancer (Review)

(2009) Singhal   INTERNATIONAL JOURNAL OF ONCOLOGY

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

(2009) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins

(2009) Aaron T. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells

(2009) Hyun-Pil Lee et al.   JOURNAL OF NEUROCHEMISTRY

Notch and the Skeleton

(2009) S. Zanotti et al.   MOLECULAR AND CELLULAR BIOLOGY

A study of the toxic effect of oxidized sunflower oil containing 4-hydroperoxy-2-nonenal and 4-hydroxy-2-nonenal on cortical TrkA receptor expression in rats

(2009) Jon Zárate et al.   NUTRITIONAL NEUROSCIENCE

The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS

(2008) Molly M. Warnke et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice

(2008) Melissa Braga et al.   APOPTOSIS

4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells

(2008) Abha Sharma et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

(2008) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Regression of prostate cancer xenografts by RLIP76 depletion

(2008) Sharad S. Singhal et al.   BIOCHEMICAL PHARMACOLOGY

RLIP76: A novel glutathione-conjugate and multi-drug transporter

(2008) Sharad S. Singhal et al.   BIOCHEMICAL PHARMACOLOGY

The extrinsic cell death pathway and the élan mortel

(2008) D Wallach et al.   CELL DEATH AND DIFFERENTIATION

ProteinN-Acylation: H2O2-Mediated Covalent Modification of Protein by Lipid Peroxidation-Derived Saturated Aldehydes

(2008) Kousuke Ishino et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Vitro and in Silico Characterization of Peroxiredoxin 6 Modified by 4-Hydroxynonenal and 4-Oxononenal

(2008) James R. Roede et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

(2008) Angel Catalá   CHEMISTRY AND PHYSICS OF LIPIDS

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

(2008) D. Demozay et al.   DIABETES

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death

(2008) Yogesh C. Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

RLIP76 in Defense of Radiation Poisoning

(2008) Jyotsana Singhal et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Use of an in Vitro Digestion Model To Study the Bioaccessibility of 4-Hydroxy-2-nonenal and Related Aldehydes Present in Oxidized Oils Rich in Omega-6 Acyl Groups

(2008) Encarnación Goicoechea et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mercapturic Acid Conjugates of 4-Hydroxy-2-nonenal and 4-Oxo-2-nonenal Metabolites Arein VivoMarkers of Oxidative Stress

(2008) Heather C. Kuiper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation

(2008) Claus Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized Lipids Formed Non-enzymatically by Reactive Oxygen Species

(2008) William L. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol, Reactive Oxygen Species, and the Formation of Biologically Active Mediators

(2008) Robert C. Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

(2008) Giovanna Cenini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Down-Regulation of Notch1 Expression is Involved in HL-60 Cell Growth Inhibition Induced by 4-Hydroxynonenal, a Product of Lipid Peroxidation

(2008) Stefania Pizzimenti et al.   Medicinal Chemistry

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-κB translocation

(2008) Yongzhen Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lipid Peroxidation Product 4-Hydroxynonenal Contributes to Bladder Smooth Muscle Damage

(2008) Rik de Jongh et al.   UROLOGY

4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase

(2008) France Vaillancourt et al.   ARTHRITIS RESEARCH & THERAPY

4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas†

(2007) Rajendra Sharma et al.   BIOCHEMISTRY

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

(2007) A Negre-Salvayre et al.   BRITISH JOURNAL OF PHARMACOLOGY

4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

(2007) G. Poli et al.   MEDICINAL RESEARCH REVIEWS

4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases

(2007) Giuseppe Poli et al.   MOLECULAR ASPECTS OF MEDICINE

Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde

(2007) Yayoi Murakami et al.   NEUROBIOLOGY OF AGING

Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells

(2007) Haider Raza et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY