EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers

Research advances in hydrogen–deuterium exchange mass spectrometry for protein epitope mapping

(2021) Haofeng Sun et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

How epigallocatechin gallate binds and assembles oligomeric forms of human alpha-synuclein

(2021) Camilla B. Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

(2021) Roberta Cascella et al.   Nature Communications

Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems

(2021) Ellie I. James et al.   CHEMICAL REVIEWS

Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications

(2021) Camilla Andersen et al.   BIOCHEMISTRY

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

(2020) Mohammad Shahnawaz et al.   NATURE

Avoiding H/D Scrambling with Minimal Ion Transmission Loss for HDX-MS/MS-ETD Analysis on a High-Resolution Q-TOF Mass Spectrometer

(2020) Daniel T. Weltz Wollenberg et al.   ANALYTICAL CHEMISTRY

Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

(2020) Ersoy Cholak et al.   FASEB JOURNAL

The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation

(2020) Rebecca Sternke-Hoffmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species

(2019) Thomas Skamris et al.   Scientific Reports

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure

(2019) Erika Ponzini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

(2019) Roberta Cascella et al.   ACS Chemical Biology

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

(2019) Parvez Alam et al.   JOURNAL OF NEUROCHEMISTRY

The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG

(2019) Tomas Sneideris et al.   Biomolecules

Pulsed Hydrogen–Deuterium Exchange Illuminates the Aggregation Kinetics of α-Synuclein, the Causative Agent for Parkinson’s Disease

(2018) Eva Illes-Toth et al.   ACS Chemical Neuroscience

Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

(2018) Cristine Betzer et al.   EMBO REPORTS

Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions

(2018) Cesar A. Ramirez-Sarmiento et al.   METHODS

Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions

(2018) Esben Trabjerg et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Inhibition of amyloid fibril formation in the variable domain of λ6 light chain mutant Wil caused by the interaction between its unfolded state and epigallocatechin-3-O-gallate

(2018) Yoshito Abe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Interpreting Hydrogen-Deuterium Exchange Events in Proteins Using Atomistic Simulations: Case Studies on Regulators of G-protein Signaling Proteins

(2018) Hossein Mohammadiarani et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Oxidation-Induced Destabilization of Model Antibody-Drug Conjugates

(2018) Jakob W. Buecheler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils

(2017) H. Wilms et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

EGCG-mediated Protection of the Membrane Disruption and Cytotoxicity Caused by the ‘Active Oligomer’ of α-Synuclein

(2017) Jee Eun Yang et al.   Scientific Reports

Intracellular soluble α-synuclein oligomers reduce pyramidal cell excitability

(2016) Timothy J. Kaufmann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cytochromecfolds through foldon-dependent native-like intermediates in an ordered pathway

(2016) Wenbing Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

(2015) Corinna Bliederhaeuser et al.   ACTA NEUROPATHOLOGICA

Challenges in the Interpretation of Protein H/D Exchange Data: A Molecular Dynamics Simulation Perspective

(2015) Robert G. McAllister et al.   BIOCHEMISTRY

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Stability and Cooperative Unfolding of α-Synuclein Oligomers

(2014) Wojciech Paslawski et al.   BIOCHEMISTRY

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicityin Vitro

(2014) Nikolai Lorenzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

(2014) Nikolai Lorenzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissecting the Effect of RNA Aptamer Binding on the Dynamics of Plasminogen Activator Inhibitor 1 Using Hydrogen/Deuterium Exchange Mass Spectrometry

(2013) Morten B. Trelle et al.   ACS Chemical Biology

Characterizing the Dynamics of α-Synuclein Oligomers Using Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry

(2013) Simon Mysling et al.   BIOCHEMISTRY

The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

(2013) Nikolai Lorenzen et al.   FEBS LETTERS

Activation of ClpP Protease by ADEP Antibiotics: Insights from Hydrogen Exchange Mass Spectrometry

(2013) Modupeola A. Sowole et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates

(2013) Alexander S. Maltsev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra

(2013) Miklos Guttman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

(2012) Jochen Klucken et al.   Autophagy

Locally Resolved Membrane Binding Affinity of the N-Terminus of α-Synuclein

(2012) Marta Robotta et al.   BIOCHEMISTRY

Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Specific Changes in the Local Flexibility of Plasminogen Activator Inhibitor 1 upon Binding to the Somatomedin B Domain of Vitronectin

(2012) Morten Beck Trelle et al.   BIOCHEMISTRY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Protein hydrogen exchange: Testing current models

(2012) John J. Skinner et al.   PROTEIN SCIENCE

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

(2011) Jun Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein

(2010) Marta Robotta et al.   CHEMPHYSCHEM

Stability of Human Growth Hormone: Influence of Methionine Oxidation on Thermal Folding

(2010) Filippo Mulinacci et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein

(2010) Min-Kyu Cho et al.   PROTEIN SCIENCE

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

(2009) Wenbo Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

(2009) Mordhwaj S. Parihar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast

(2009) Katherina Vamvaca et al.   JOURNAL OF MOLECULAR BIOLOGY

Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group

(2009) Woon Ki Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic characterization of the covalent interactions between (−)-epigallocatechin gallate and peptides under physiological conditions by mass spectrometry

(2009) Dong Cao et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Effects of Protein Oxidation on the Structure and Stability of Model Discoidal High-Density Lipoproteins†

(2008) Shobini Jayaraman et al.   BIOCHEMISTRY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA