Structure-Based Drug Design and Synthesis of Novel N-Aryl-2,4-bithiazole-2-amine CYP1B1-Selective Inhibitors in Overcoming Taxol Resistance in A549 Cells

New Perspectives of CYP1B1 Inhibitors in the Light of Molecular Studies

(2021) Renata Mikstacka et al.   Processes

Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation

(2021) András Lánczky et al.   JOURNAL OF MEDICAL INTERNET RESEARCH

Synthesis, characterization and evaluation of optical band gap of new semiconductor polymers with N-aryl- 2,5-diphenyl-pyrrole units

(2021) Olivia Monroy et al.   JOURNAL OF MOLECULAR STRUCTURE

FAK-Dependent Cell Motility and Cell Elongation

(2020) Kazuo Katoh   Cells

Carvedilol serves as a novel CYP1B1 inhibitor, a systematic drug repurposing approach through structure-based virtual screening and experimental verification

(2020) Ying Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TIMER2.0 for analysis of tumor-infiltrating immune cells

(2020) Taiwen Li et al.   NUCLEIC ACIDS RESEARCH

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

(2020) Rui Liu et al.   Cell Death & Disease

Thionation of Optically Pure N-C Axially Chiral Quinazolin-4-one Derivatives with Lawesson’s Reagent

(2020) Erina Niijima et al.   JOURNAL OF ORGANIC CHEMISTRY

Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells

(2019) Yaxun Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone

(2019) Shu-Yu Lin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism

(2019) Xu Mao et al.   DRUG METABOLISM AND DISPOSITION

Long-term Exposure of 4-hydroxyestradiol Induces the Cancer Cell Characteristics via Upregulating CYP1B1 in MCF-10A Cells

(2019) Wu Lanxiang et al.   TOXICOLOGY MECHANISMS AND METHODS

Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin

(2019) Hao Lin et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors

(2019) Jinyun Dong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR

(2018) Imran Shair Mohammad et al.   BIOMEDICINE & PHARMACOTHERAPY

Benzo[ d ]thiazole-2-carbanilides as new anti-TB chemotypes: Design, synthesis, biological evaluation, and structure-activity relationship

(2018) Tejas M. Dhameliya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors

(2018) Nan-nan Wang et al.   EXPERIMENTAL CELL RESEARCH

Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity and Selectivity

(2018) Raphaël Dutour et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines

(2017) Neill J. Horley et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells

(2017) Nicola E. Wilsher et al.   FOOD AND CHEMICAL TOXICOLOGY

CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer

(2016) Zhenbo Tu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

COEXPEDIA: exploring biomedical hypotheses via co-expressions associated with medical subject headings (MeSH)

(2016) Sunmo Yang et al.   NUCLEIC ACIDS RESEARCH

CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/β-Catenin Signaling via Sp1 Upregulation

(2016) Yeo-Jung Kwon et al.   PLoS One

Design and Synthesis of New α-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression

(2015) Jiahua Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

KEGG as a reference resource for gene and protein annotation

(2015) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

(2015) Catherine Wilson et al.   Oncotarget

Inhibitors and Prodrugs Targeting CYP1: A Novel Approach in Cancer Prevention and Therapy

(2014) Jiahua Cui et al.   CURRENT MEDICINAL CHEMISTRY

CYP1B1 enhances the resistance of epithelial ovarian cancer cells to paclitaxel in vivo and in vitro

(2014) ZHUANGYAN ZHU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

miR-17-5p Downregulation Contributes to Paclitaxel Resistance of Lung Cancer Cells through Altering Beclin1 Expression

(2014) Abhisek Chatterjee et al.   PLoS One

Silica gel catalyzed α-bromination of ketones using N-bromosuccinimide: An easy and rapid method

(2013) Bodireddy Mohan Reddy et al.   CHINESE CHEMICAL LETTERS

Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2

(2010) Hyunho Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Characterization of the Complex between α-Naphthoflavone and Human Cytochrome P450 1B1

(2010) An Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-Pyridylanilinothiazoles That Selectively Target von Hippel−Lindau Deficient Renal Cell Carcinoma Cells by Inducing Autophagic Cell Death

(2009) Michael P. Hay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance

(2008) V G Martinez et al.   BRITISH JOURNAL OF CANCER