Shedding Light on Immunological Research in Lyon, France. IRCI2022 Brings the Scientific World to Lyon and Bridges the Latest Immunological Findings in Cancer and Infection

Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

(2022) Assia Asrir et al.   CANCER CELL

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

(2022) Saskia F. Erttmann et al.   IMMUNITY

Human autoantibodies underlying infectious diseases

(2022) Anne Puel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

(2022) John A. McCulloch et al.   NATURE MEDICINE

NK cells limit therapeutic vaccine–induced CD8 + T cell immunity in a PD-L1–dependent manner

(2022) Mariana O. Diniz et al.   Science Translational Medicine

Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses

(2022) Javier Rodríguez-Ubreva et al.   Nature Communications

Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

(2021) Yael C. Cohen et al.   NATURE MEDICINE

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

(2021) Diwakar Davar et al.   SCIENCE

The Next Decade of Immune Checkpoint Therapy

(2021) Padmanee Sharma et al.   Cancer Discovery

Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs

(2021) Jonathan Lopez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic endotoxemia is dictated by the type of lipopolysaccharide

(2021) Fernando F. Anhê et al.   Cell Reports

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

(2021) Paul Bastard et al.   Science Immunology

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

(2021) Takaki Asano et al.   Science Immunology

Donor Memory-like NK cells Persist and Induce Remissions in Pediatric Patients with Relapsed AML after Transplant

(2021) Jeffrey J Bednarski et al.   BLOOD

Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery

(2021) Thomas J. Hayman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

(2021) Leo Swadling et al.   NATURE

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

(2021) Christine N. Spencer et al.   SCIENCE

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

(2021) Esther Hoste et al.   Nature Communications

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

(2020) Lien Verboom et al.   Cell Reports

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

(2020) Santosha A. Vardhana et al.   NATURE IMMUNOLOGY

Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

(2020) Anett Jandke et al.   Nature Communications

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting

(2019) Yi‐Ru Yu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

(2019) Hui Jiang et al.   EMBO JOURNAL

A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity

(2019) Arne Martens et al.   Cold Spring Harbor Perspectives in Biology

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

(2019) Yin Wu et al.   Science Translational Medicine

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

(2017) Vangelis Kondylis et al.   IMMUNOLOGICAL REVIEWS

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif

(2017) Shunya Sakurai et al.   Acta Crystallographica Section F-Structural Biology Communications

Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity

(2016) Saskia F. Erttmann et al.   IMMUNITY

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

(2016) Rizwan Romee et al.   Science Translational Medicine

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation

(2015) S. C. Warth et al.   EMBO JOURNAL

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR

(2015) Yogesh Singh et al.   JOURNAL OF IMMUNOLOGY

Whole-genome fingerprint of the DNA methylome during human B cell differentiation

(2015) Marta Kulis et al.   NATURE GENETICS

The past, present and future of neutralizing antibodies for hepatitis C virus

(2014) Jonathan K. Ball et al.   ANTIVIRAL RESEARCH

Pembrolizumab: First Global Approval

(2014) Raewyn M. Poole   DRUGS

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells

(2014) Antoine Marcais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE