Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

(2020) Mohindar M. Karunakaran et al.   IMMUNITY

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease

(2019) Shun He et al.   NATURE

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

(2019) Yunyun Yang et al.   IMMUNITY

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

Butyrophilin-like 3 Directly Binds a Human Vγ4+ T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen

(2019) Carrie R. Willcox et al.   IMMUNITY

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

(2019) Yin Wu et al.   Science Translational Medicine

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

(2019) Lucie Abeler-Dörner et al.   NATURE IMMUNOLOGY

Mice lacking all of the Skint family genes

(2018) Tomoya Narita et al.   INTERNATIONAL IMMUNOLOGY

Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa

(2018) Madeleine D. Hu et al.   JOURNAL OF IMMUNOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

(2018) Ayano C. Kohlgruber et al.   NATURE IMMUNOLOGY

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

(2018) Andreas E. Moor et al.   CELL

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues

(2017) Ryan T. Sowell et al.   JOURNAL OF IMMUNOLOGY

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

(2017) Siyi Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Murine Butyrophilin-Like 1 and Btnl6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes

(2016) Cristina Lebrero-Fernández et al.   Frontiers in Immunology

γδ Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice

(2015) Karen L. Edelblum et al.   GASTROENTEROLOGY

The SKINT1-Like Gene Is Inactivated in Hominoids But Not in All Primate Species: Implications for the Origin of Dendritic Epidermal T Cells

(2015) Rania Hassan Mohamed et al.   PLoS One

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

IL-15 Does Not Affect IEL Development in the Thymus but Regulates Homeostasis of Putative Precursors and Mature CD8  + IELs in the Intestine

(2014) Y.-G. Lai et al.   JOURNAL OF IMMUNOLOGY

Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human V 2V 2 T Cells

(2013) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

(2013) Jia Zhu et al.   NATURE

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

The Molecular Basis for Modulation of Human Vγ9Vδ2 T Cell Responses by CD277/Butyrophilin-3 (BTN3A)-specific Antibodies

(2012) Aparna Palakodeti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes

(2011) A. Bas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γδ T Cells and the Lymphoid Stress-Surveillance Response

(2009) Adrian C. Hayday   IMMUNITY

TCR-inducible PLZF transcription factor required for innate phenotype of a subset of    T cells with restricted TCR diversity

(2009) T. Kreslavsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

(2008) Lynn M Boyden et al.   NATURE GENETICS

Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

(2008) Jessica Strid et al.   NATURE IMMUNOLOGY