Tick Salivary Kunitz-Type Inhibitors: Targeting Host Hemostasis and Immunity to Mediate Successful Blood Feeding

Host Immune Responses to Salivary Components - A Critical Facet of Tick-Host Interactions

(2022) Abid Ali et al.   Frontiers in Cellular and Infection Microbiology

Mast Cell and Basophil Granule Proteases - In Vivo Targets and Function

(2022) Lars Hellman et al.   Frontiers in Immunology

A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate

(2022) Aline R. M. Lobba et al.   Frontiers in Molecular Biosciences

The Impact of RNA Interference in Tick Research

(2022) José de la Fuente et al.   Pathogens

Structural and functional properties of rBmTI-A: A Kunitz-BPTI serine protease inhibitor with therapeutical potential

(2022) Graziele Cristina Ferreira et al.   BIOCHIMIE

Insights into the Role of Tick Salivary Protease Inhibitors during Ectoparasite–Host Crosstalk

(2021) Mohamed Amine Jmel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sialotranscriptomics of the argasid tick Ornithodoros moubata along the trophogonic cycle

(2021) Ana Oleaga et al.   PLoS Neglected Tropical Diseases

Amblyomma sculptum Salivary Protease Inhibitors as Potential Anti-Tick Vaccines

(2021) Gabriel Cerqueira Alves Costa et al.   Frontiers in Immunology

RNA-seq analysis and gene expression dynamics in the salivary glands of the argasid tick Ornithodoros erraticus along the trophogonic cycle

(2021) Ricardo Pérez-Sánchez et al.   Parasites & Vectors

Transcriptomic Analysis of Salivary Glands of Ornithodoros brasiliensis Aragão, 1923, the Agent of a Neotropical Tick-Toxicosis Syndrome in Humans

(2021) Jose Reck et al.   Frontiers in Physiology

Complement Evasion by Lyme Disease Spirochetes

(2020) Jon T. Skare et al.   TRENDS IN MICROBIOLOGY

Mast Cells and Basophils: From Malevolent Design to Coevolutionary Arms Race

(2020) Anderson Sá-Nunes et al.   TRENDS IN PARASITOLOGY

Innate Immune Response to Tick-Borne Pathogens: Cellular and Molecular Mechanisms Induced in the Hosts

(2020) Alessandra Torina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evolutionary Aspects of the Structural Convergence and Functional Diversification of Kunitz-Domain Inhibitors

(2020) Manasi Mishra   JOURNAL OF MOLECULAR EVOLUTION

TickSialoFam (TSFam): A Database That Helps to Classify Tick Salivary Proteins, a Review on Tick Salivary Protein Function and Evolution, With Considerations on the Tick Sialome Switching Phenomenon

(2020) José M. C. Ribeiro et al.   Frontiers in Cellular and Infection Microbiology

Immunobiology of Acquired Resistance to Ticks

(2020) Hajime Karasuyama et al.   Frontiers in Immunology

Failed Disruption of Tick Feeding, Viability, and Molting after Immunization of Mice and Sheep with Recombinant Ixodes ricinus Salivary Proteins IrSPI and IrLip1

(2020) Consuelo Almazán et al.   Vaccines

The sialotranscriptome of the gopher-tortoise tick, Amblyomma tuberculatum

(2020) Shahid Karim et al.   Ticks and Tick-Borne Diseases

Corrigendum to “Pro-apoptotic effects of Amblyomin-X in murine renal cell carcinoma “in vitro” [Biomed. Pharmacother. 66 (2012) 64–69]

(2019) Erica Mie Akagi et al.   BIOMEDICINE & PHARMACOTHERAPY

RNA-seq analysis of the salivary glands and midgut of the Argasid tick Ornithodoros rostratus

(2019) Ricardo N. Araujo et al.   Scientific Reports

Deciphering Biological Processes at the Tick-Host Interface Opens New Strategies for Treatment of Human Diseases

(2019) Iveta Štibrániová et al.   Frontiers in Physiology

Effects of the serine protease inhibitor rBmTI-A in an experimental mouse model of chronic allergic pulmonary inflammation

(2019) Ariana Corrêa Florencio et al.   Scientific Reports

Small protease inhibitors in tick saliva and salivary glands and their role in tick-host-pathogen interactions

(2019) Larissa Almeida Martins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

rBmTI-6 attenuates pathophysiological and inflammatory parameters of induced emphysema in mice

(2018) Adriana Feliciano Alves Duran et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Serine protease inhibitors containing a Kunitz domain: their role in modulation of host inflammatory responses and parasite survival

(2018) Mariana T.Q. de Magalhães et al.   MICROBES AND INFECTION

Wonders of tick saliva

(2018) Patricia A. Nuttall   Ticks and Tick-Borne Diseases

Identification and anticoagulant activity of a novel Kunitz-type protein HA11 from the salivary gland of the tick Hyalomma asiaticum

(2017) Houshuang Zhang et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

Mining a differential sialotranscriptome of Rhipicephalus microplus guides antigen discovery to formulate a vaccine that reduces tick infestations

(2017) Sandra R. Maruyama et al.   Parasites & Vectors

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

(2017) Melissa E. Schechter et al.   Science Translational Medicine

Ticks parasitised feathered dinosaurs as revealed by Cretaceous amber assemblages

(2017) Enrique Peñalver et al.   Nature Communications

Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels

(2017) Martín Fló et al.   PLoS Pathogens

Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

(2017) Jindřich Chmelař et al.   Frontiers in Cellular and Infection Microbiology

The Essential Role of Tick Salivary Glands and Saliva in Tick Feeding and Pathogen Transmission

(2017) Ladislav Šimo et al.   Frontiers in Cellular and Infection Microbiology

Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo

(2016) Vania G. Branco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Plasma Kallikrein Inhibitors in Cardiovascular Disease

(2016) Dhaval Kolte et al.   Cardiology in Review

Neutral serine proteases of neutrophils

(2016) Ralph Kettritz   IMMUNOLOGICAL REVIEWS

Characterization, biomedical and agricultural applications of protease inhibitors: A review

(2016) Tooba Naz Shamsi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick–Host Interactions

(2016) Jindřich Chmelař et al.   TRENDS IN PARASITOLOGY

BmTI-A, a Kunitz type inhibitor from Rhipicephalus microplus able to interfere in vessel formation

(2016) Tatiane S. Soares et al.   VETERINARY PARASITOLOGY

In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus

(2016) Teresa C. Assumpção et al.   PLoS Neglected Tropical Diseases

CHARACTERIZATION OF A NEW KUNITZ-TYPE SERINE PROTEASE INHIBITOR FROM THE HARD TICKRhipicephalus hemaphysaloides

(2015) Jie Cao et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

An Insight into the Sialome of the Lone Star Tick, Amblyomma americanum, with a Glimpse on Its Time Dependent Gene Expression

(2015) Shahid Karim et al.   PLoS One

The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma cajennense ticks, uncovered by 454-based RNA-seq

(2014) Gustavo Garcia et al.   Parasites & Vectors

A Treatment with a Protease Inhibitor Recombinant from the Cattle Tick (Rhipicephalus Boophilus microplus) Ameliorates Emphysema in Mice

(2014) Juliana D. Lourenço et al.   PLoS One

Structural Findings and Molecular Modeling Approach of a TFPI-Like Inhibitor

(2014) Kerly Mesquita Pasqualoto et al.   PROTEIN AND PEPTIDE LETTERS

Prediction of Kunitz ion channel effectors and protease inhibitors from the Ixodes ricinus sialome

(2014) James J. Valdés et al.   Ticks and Tick-Borne Diseases

The potential of neutrophil elastase inhibitors as anti-inflammatory therapies

(2013) Peter A. Henriksen   CURRENT OPINION IN HEMATOLOGY

Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder

(2013) James J. Valdés et al.   PLoS One

A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis

(2012) Janaína Souza Ventura et al.   BIOMEDICINE & PHARMACOTHERAPY

Structure and function of invertebrate Kunitz serine protease inhibitors

(2012) Shiwanthi Ranasinghe et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A hemocyte-derived Kunitz–BPTI-type chymotrypsin inhibitor, HlChI, from the ixodid tick Haemaphysalis longicornis, plays regulatory functions in tick blood-feeding processes

(2012) M. Abdul Alim et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production

(2012) Durvanei Augusto Maria et al.   INVESTIGATIONAL NEW DRUGS

Tick salivary secretion as a source of antihemostatics

(2012) Jindrich Chmelar et al.   Journal of Proteomics

Actions of the Kunitz-type serine protease inhibitor Amblyomin-X on VEGF-A-induced angiogenesis

(2012) C.C. Drewes et al.   TOXICON

Protective immunity against tick infestation in cattle vaccinated with recombinant trypsin inhibitor of Rhipicephalus microplus

(2012) Renato Andreotti et al.   VACCINE

Expression and functional characterization of boophilin, a thrombin inhibitor from Rhipicephalus (Boophilus) microplus midgut

(2012) Tatiane Sanches Soares et al.   VETERINARY PARASITOLOGY

Plant Proteinases and Inhibitors: An Overview of Biological Function and Pharmacological Activity

(2011) Marco T.R. Gomes et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

(2010) J. Chmelar et al.   BLOOD

A Kunitz Protease Inhibitor fromDermacentor variabilis, a Vector for Spotted Fever Group Rickettsiae, LimitsRickettsia montanensisInvasion

(2010) Shane M. Ceraul et al.   INFECTION AND IMMUNITY

Characterization of the anticoagulant protein Rhipilin-1 from the Rhipicephalus haemaphysaloides tick

(2010) Xiao Gao et al.   JOURNAL OF INSECT PHYSIOLOGY

A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system

(2010) Ana Marisa Chudzinski-Tavassi et al.   TOXICON

Action of plant proteinase inhibitors on enzymes of physiopathological importance

(2009) Maria Luiza V. Oliva et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition

(2009) I.F.C. Batista et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The role of saliva in tick feeding

(2009) Ivo et al.   Frontiers in Bioscience-Landmark

Tick-derived Kunitz-type inhibitors as antihemostatic factors

(2009) María Ángeles Corral-Rodríguez et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ir-CPI, a coagulation contact phase inhibitor from the tickIxodes ricinus, inhibits thrombus formation without impairing hemostasis

(2009) Yves Decrem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Ion-channel Modulator from the Saliva of the Brown Ear Tick has a Highly Modified Kunitz/BPTI Structure

(2009) Guido C. Paesen et al.   JOURNAL OF MOLECULAR BIOLOGY

Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model

(2009) T. C. CARNEIRO-LOBO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A Kunitz-type proteinase inhibitor from the midgut of the ixodid tick, Haemaphysalis longicornis, and its endogenous target serine proteinase

(2009) Takeharu Miyoshi et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Kunitz-Like Modulatory Protein Haemangin Is Vital for Hard Tick Blood-Feeding Success

(2009) M. Khyrul Islam et al.   PLoS Pathogens

Serine peptidases: Classification, structure and function

(2008) M. J. Page et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional Characterization and Novel Rickettsiostatic Effects of a Kunitz-Type Serine Protease Inhibitor from the Tick Dermacentor variabilis

(2008) S. M. Ceraul et al.   INFECTION AND IMMUNITY

Hemalin, a thrombin inhibitor isolated from a midgut cDNA library from the hard tick Haemaphysalis longicornis

(2008) Min Liao et al.   JOURNAL OF INSECT PHYSIOLOGY

Blood Coagulation, Inflammation, and Malaria

(2008) Ivo M. B. Francischetti et al.   MICROCIRCULATION

Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

(2008) Sandra Macedo-Ribeiro et al.   PLoS One

rBmTI-6, a Kunitz-BPTI domain protease inhibitor from the tick Boophilus microplus, its cloning, expression and biochemical characterization

(2008) Sergio D. Sasaki et al.   VETERINARY PARASITOLOGY