Innate Immune Response to Tick-Borne Pathogens: Cellular and Molecular Mechanisms Induced in the Hosts

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms

(2020) Michal P. Wandel et al.   NATURE IMMUNOLOGY

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

(2020) José Carlos Santos et al.   Nature Communications

Anaplasma phagocytophilum evolves in geographical and biotic niches of vertebrates and ticks

(2019) Ryanne I. Jaarsma et al.   Parasites & Vectors

Risks of cattle babesiosis (Babesia bovis) outbreaks in a semi-arid region of Argentina

(2019) Nicolás Morel et al.   PREVENTIVE VETERINARY MEDICINE

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

(2018) Shouya Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species

(2018) Catherine E. Vrentas et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Anaplasma phagocytophilum-Related Defects in CD8, NKT, and NK Lymphocyte Cytotoxicity

(2018) Diana G. Scorpio et al.   Frontiers in Immunology

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action

(2018) Jenni A. Hayward et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Exploring the TLR and NLR signaling pathway relevant molecules induced by the Theileria annulata infection in calves

(2018) Fangyuan Yin et al.   PARASITOLOGY RESEARCH

The Complexity of Piroplasms Life Cycles

(2018) Marie Jalovecka et al.   Frontiers in Cellular and Infection Microbiology

Genetic diversity and molecular epidemiology of Anaplasma

(2017) Mara Battilani et al.   INFECTION GENETICS AND EVOLUTION

Chlamydiales , Anaplasma and Bartonella : persistence and immune escape of intracellular bacteria

(2017) Aurélie Scherler et al.   MICROBES AND INFECTION

Increased level and interferon-γ production of circulating natural killer cells in patients with scrub typhus

(2017) Seung-Ji Kang et al.   PLoS Neglected Tropical Diseases

Microbial Invasion vs. Tick Immune Regulation

(2017) Daniel E. Sonenshine et al.   Frontiers in Cellular and Infection Microbiology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Persisting Rickettsia typhi Causes Fatal Central Nervous System Inflammation

(2016) Anke Osterloh et al.   INFECTION AND IMMUNITY

MyD88 Mediates Instructive Signaling in Dendritic Cells and Protective Inflammatory Response during Rickettsial Infection

(2016) Jeremy Bechelli et al.   INFECTION AND IMMUNITY

Ehrlichia's molecular tricks to manipulate their host cells

(2016) Amal Moumène et al.   MICROBES AND INFECTION

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells

(2016) Stefanie Papp et al.   PLoS Neglected Tropical Diseases

Tick–Host–Pathogen Interactions: Conflict and Cooperation

(2016) José de la Fuente et al.   PLoS Pathogens

Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy

(2016) Taslima T. Lina et al.   Frontiers in Cellular and Infection Microbiology

NK Cell-Mediated Regulation of Protective Memory Responses against Intracellular Ehrlichial Pathogens

(2016) Samar Habib et al.   PLoS One

Mitochondrial Genome Sequences and Structures Aid in the Resolution of Piroplasmida phylogeny

(2016) Megan E. Schreeg et al.   PLoS One

Type I Interferon Contributes to Noncanonical Inflammasome Activation, Mediates Immunopathology, and Impairs Protective Immunity during Fatal Infection with Lipopolysaccharide-Negative Ehrlichiae

(2015) Qin Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The mRNA expression of immune-related genes in crossbred and Tharparkar cattle in response to in vitro infection with Theileria annulata

(2015) Prashant Dewangan et al.   MOLECULAR BIOLOGY REPORTS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

Essential Domains of Anaplasma phagocytophilum Invasins Utilized to Infect Mammalian Host Cells

(2015) David Seidman et al.   PLoS Pathogens

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Dissemination of Orientia tsutsugamushi and Inflammatory Responses in a Murine Model of Scrub Typhus

(2014) Christian A. Keller et al.   PLoS Neglected Tropical Diseases

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Detection of Natural Killer T Cells in Mice Infected withRickettsia conorii

(2013) M. P. La Manna et al.   Transboundary and Emerging Diseases

Anaplasma phagocytophilum—a widespread multi-host pathogen with highly adaptive strategies

(2013) Snorre Stuen et al.   Frontiers in Cellular and Infection Microbiology

Host specialization in ticks and transmission of tick-borne diseases: a review

(2013) Karen D. McCoy et al.   Frontiers in Cellular and Infection Microbiology

Ticks and tick-borne pathogens at the cutaneous interface: host defenses, tick countermeasures, and a suitable environment for pathogen establishment

(2013) Stephen Wikel   Frontiers in Microbiology

Contribution of NK Cells to the Innate Phase of Host Protection Against an Intracellular Bacterium Targeting Systemic Endothelium

(2012) Rong Fang et al.   AMERICAN JOURNAL OF PATHOLOGY

Babesia: A world emerging

(2012) Leonhard Schnittger et al.   INFECTION GENETICS AND EVOLUTION

Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins

(2012) Jeeba A. Kuriakose et al.   MICROBES AND INFECTION

Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum

(2011) Y. Rikihisa   CLINICAL MICROBIOLOGY REVIEWS

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Tyrosine-Phosphorylated Ehrlichia chaffeensis and Ehrlichia canis Tandem Repeat Orthologs Contain a Major Continuous Cross-Reactive Antibody Epitope in Lysine-Rich Repeats

(2011) Jere W. McBride et al.   INFECTION AND IMMUNITY

Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice

(2011) Edward M. Behrens et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution of Antigen Variation in the Tick-Borne Pathogen Anaplasma phagocytophilum

(2011) D. Rejmanek et al.   MOLECULAR BIOLOGY AND EVOLUTION

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Theileria annulata induces abberrant T cell activation in vitro and in vivo

(2010) J. D. M. CAMPBELL et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

T cell activation by Theileria annulata-infected macrophages correlates with cytokine production

(2010) D. J. BROWN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Raising the NKT cell family

(2010) Dale I Godfrey et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Dynamics of bovine spleen cell populations during the acute response to Babesia bovis infection: an immunohistological study

(2010) D. A. SCHNEIDER et al.   PARASITE IMMUNOLOGY

Molecular Characterization of Antibody Epitopes of Ehrlichia chaffeensis Ankyrin Protein 200 and Tandem Repeat Protein 47 and Evaluation of Synthetic Immunodeterminants for Serodiagnosis of Human Monocytotropic Ehrlichiosis

(2009) T. Luo et al.   Clinical and Vaccine Immunology

Host-cell interactions with pathogenicRickettsiaspecies

(2009) Sanjeev K Sahni et al.   Future Microbiology

Infection with Anaplasma phagocytophilum Induces Multilineage Alterations in Hematopoietic Progenitor Cells and Peripheral Blood Cells

(2009) J. L. Johns et al.   INFECTION AND IMMUNITY

An Ehrlichia chaffeensis Tandem Repeat Protein Interacts with Multiple Host Targets Involved in Cell Signaling, Transcriptional Regulation, and Vesicle Trafficking

(2009) A. Wakeel et al.   INFECTION AND IMMUNITY

Lipids from attenuated and virulent Babesia bovis strains induce differential TLR2-mediated macrophage activation

(2009) G. Gimenez et al.   MOLECULAR IMMUNOLOGY

Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum

(2009) Yasuko Rikihisa   VETERINARY PARASITOLOGY

Genome-Based Construction of the Metabolic Pathways ofOrientia tsutsugamushiand Comparative Analysis within the Rickettsiales Order

(2008) Chan-Ki Min et al.   COMPARATIVE AND FUNCTIONAL GENOMICS

The Absence of Toll-Like Receptor 4 Signaling in C3H/HeJ Mice Predisposes Them to Overwhelming Rickettsial Infection and Decreased Protective Th1 Responses

(2008) J. M. Jordan et al.   INFECTION AND IMMUNITY

A Variable-Length PCR Target Protein of Ehrlichia chaffeensis Contains Major Species-Specific Antibody Epitopes in Acidic Serine-Rich Tandem Repeats

(2008) T. Luo et al.   INFECTION AND IMMUNITY

Review: Innate immunity to tropical theileriosis

(2008) Jabbar S. Ahmed et al.   Innate Immunity

Rickettsiae Stimulate Dendritic Cells through Toll‐Like Receptor 4, Leading to Enhanced NK Cell Activation In Vivo

(2008) Jeffrey M. Jordan et al.   JOURNAL OF INFECTIOUS DISEASES

C3 contributes to the cross-protective immunity induced by Babesia gibsoni phosphoriboprotein P0 against a lethal B. rodhaini infection

(2008) M. A. TERKAWI et al.   PARASITE IMMUNOLOGY

Bovine NK cells acquire cytotoxic activity and produce IFN-γ after stimulation by Mycobacterium bovis BCG- or Babesia bovis-exposed splenic dendritic cells

(2008) R.G. Bastos et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Defining the immune response to Ehrlichia species using murine models

(2008) Stephen K. Chapes et al.   VETERINARY PARASITOLOGY