A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate

The role of phosphatidylserine on the membrane in immunity and blood coagulation

(2022) Jiao Wang et al.   Biomarker Research

Insights into the Role of Tick Salivary Protease Inhibitors during Ectoparasite–Host Crosstalk

(2021) Mohamed Amine Jmel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Roles of the Ubiquitin–Proteasome System in the Endoplasmic Reticulum Stress Pathway

(2021) Junyan Qu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relationship between Hypercoagulable State and Circulating Tumor Cells in Peripheral Blood, Pathological Characteristics, and Prognosis of Lung Cancer Patients

(2021) Yanhua Jiao et al.   Evidence-based Complementary and Alternative Medicine

Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model

(2020) Flavio Lichtenstein et al.   Scientific Reports

Beyond thrombosis: the impact of tissue factor signaling in cancer

(2020) Dusten Unruh et al.   Journal of Hematology & Oncology

Tick Salivary Compounds for Targeted Immunomodulatory Therapy

(2020) Hajer Aounallah et al.   Frontiers in Immunology

NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition

(2019) Viviane S. De Paula et al.   BLOOD

New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X

(2019) Lorena Favaro Pavon et al.   Scientific Reports

The Use of Tick Salivary Proteins as Novel Therapeutics

(2019) Jindřich Chmelař et al.   Frontiers in Physiology

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

(2019) Inbar Shlomovitz et al.   Cell Communication and Signaling

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation

(2018) Masaki Tsuchiya et al.   Nature Communications

Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice

(2018) Pamela Boufleur et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells

(2018) Mariana Costa Braga Schmidt et al.   Cell Adhesion & Migration

TFPI-2 suppresses breast cancer cell proliferation and invasion through regulation of ERK signaling and interaction with actinin-4 and myosin-9

(2018) Guangli Wang et al.   Scientific Reports

Saliva of hematophagous insects: a multifaceted toolkit

(2018) Bruno Arcà et al.   Current Opinion in Insect Science

Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody

(2018) Winn Aung et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment

(2017) Haiming Luo et al.   MOLECULAR PHARMACEUTICS

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Serine Protease Inhibitors in Ticks: An Overview of Their Role in Tick Biology and Tick-Borne Pathogen Transmission

(2017) Adrien A. Blisnick et al.   Frontiers in Cellular and Infection Microbiology

The Essential Role of Tick Salivary Glands and Saliva in Tick Feeding and Pathogen Transmission

(2017) Ladislav Šimo et al.   Frontiers in Cellular and Infection Microbiology

Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo

(2016) Vania G. Branco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates

(2016) Ana Marisa Chudzinski-Tavassi et al.   BIOMEDICINE & PHARMACOTHERAPY

Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X

(2016) Mario T.F. Pacheco et al.   EXPERIMENTAL CELL RESEARCH

Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell

(2016) Katia L. P. Morais et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model

(2016) Jean Gabriel de Souza et al.   Oncotarget

Cross-species models of human melanoma

(2015) Louise van der Weyden et al.   JOURNAL OF PATHOLOGY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

99mTc-ixolaris targets glioblastoma-associated tissue factor: In vitro and pre-clinical applications

(2015) Thiago Barboza et al.   THROMBOSIS RESEARCH

Post-transcriptional control of Amblyomin-X on secretion of vascular endothelial growth factor and expression of adhesion molecules in endothelial cells

(2015) C.C. Drewes et al.   TOXICON

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

PECAM-1: regulator of endothelial junctional integrity

(2014) Jamie R. Privratsky et al.   CELL AND TISSUE RESEARCH

Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma

(2014) Lenka Kubiczkova et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dynein Function and Protein Clearance Changes in Tumor Cells Induced by a Kunitz-Type Molecule, Amblyomin-X

(2014) Mario T. F. Pacheco et al.   PLoS One

Structural Findings and Molecular Modeling Approach of a TFPI-Like Inhibitor

(2014) Kerly Mesquita Pasqualoto et al.   PROTEIN AND PEPTIDE LETTERS

Reassessment of the taxonomic status of Amblyomma cajennense (Fabricius, 1787) with the description of three new species, Amblyomma tonelliae n. sp., Amblyomma interandinum n. sp. and Amblyomma patinoi n. sp., and reinstatement of Amblyomma mixtum Koch, 1844, and Amblyomma sculptum Berlese, 1888 (Ixodida: Ixodidae)

(2014) Santiago Nava et al.   Ticks and Tick-Borne Diseases

Modulation of ER stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of GRP78

(2013) Mehdi Hammadi et al.   FASEB JOURNAL

Rational development of a novel TFPI-like inhibitor fromAmblyomma cajennensetick

(2013) Katia L. P. Morais et al.   Toxin Reviews

Ecology, biology and distribution of spotted-fever tick vectors in Brazil

(2013) Matias P. J. Szabó et al.   Frontiers in Cellular and Infection Microbiology

Beneficial role of overexpression of TFPI-2 on tumour progression in human small cell lung cancer

(2013) Marion Lavergne et al.   FEBS Open Bio

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Pro-apoptotic effects of Amblyomin-X in murine renal cell carcinoma “in vitro”

(2012) Erica Mie Akagi et al.   BIOMEDICINE & PHARMACOTHERAPY

A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis

(2012) Janaína Souza Ventura et al.   BIOMEDICINE & PHARMACOTHERAPY

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production

(2012) Durvanei Augusto Maria et al.   INVESTIGATIONAL NEW DRUGS

The tick-derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells

(2012) T. C. CARNEIRO-LOBO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Actions of the Kunitz-type serine protease inhibitor Amblyomin-X on VEGF-A-induced angiogenesis

(2012) C.C. Drewes et al.   TOXICON

In search of a novel target — Phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy

(2011) Sabrina Riedl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The relationship between tissue factor and cancer progression: insights from bench and bedside

(2011) Y. W. van den Berg et al.   BLOOD

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

Regulation of Endothelial Cell Adhesion Molecule Expression by Mast Cells, Macrophages, and Neutrophils

(2011) Jie Zhang et al.   PLoS One

Sensing Phosphatidylserine in Cellular Membranes

(2011) Jason G. Kay et al.   SENSORS

Proteasome inhibitors in cancer therapy

(2011) Lisa J. Crawford et al.   Journal of Cell Communication and Signaling

Proteasome inhibitors: Dozens of molecules and still counting

(2010) Geoffroy de Bettignies et al.   BIOCHIMIE

Patenting bioactive molecules from biodiversity: the Brazilian experience

(2010) Renata Campos Nogueira et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

NMR structure determination of tick anticoagulant peptide (TAP)

(2010) Marguerita S.L. Lim-Wilby et al.   PROTEIN SCIENCE

A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system

(2010) Ana Marisa Chudzinski-Tavassi et al.   TOXICON

A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition

(2009) I.F.C. Batista et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tissue Factor and PAR2 Signaling in the Tumor Microenvironment

(2009) Florence Schaffner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The dynamic Rab11-FIPs

(2009) Conor P. Horgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Serine Protease Inhibitor Protease Nexin-1 Controls Mammary Cancer Metastasis through LRP-1-Mediated MMP-9 Expression

(2009) B. Fayard et al.   CANCER RESEARCH

A Novel Role for Tissue Factor Pathway Inhibitor-2 in the Therapy of Human Esophageal Carcinoma

(2009) Yuliang Ran et al.   HUMAN GENE THERAPY

Tick-derived Kunitz-type inhibitors as antihemostatic factors

(2009) María Ángeles Corral-Rodríguez et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model

(2009) T. C. CARNEIRO-LOBO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Molecular diversity of anticoagulants from haematophagous animals

(2009) Cho Koh et al.   THROMBOSIS AND HAEMOSTASIS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Characterisation of haematological profiles and low risk of thromboembolic events with bortezomib in patients with relapsed multiple myeloma

(2008) Sagar Lonial et al.   BRITISH JOURNAL OF HAEMATOLOGY

Plasminogen Activator Inhibitor-1 Protects Endothelial Cells from FasL-Mediated Apoptosis

(2008) Khalid Bajou et al.   CANCER CELL

rNAPc2 Inhibits Colorectal Cancer in Mice through Tissue Factor

(2008) J. Zhao et al.   CLINICAL CANCER RESEARCH

Rapid Characterization of Drug-drug Interaction in Plasma Protein Binding using a Surface Plasmon Resonance Biosensor

(2008) Yukihiro Kuroda et al.   Drug Metabolism and Pharmacokinetics

A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse

(2008) Gerli Rosengren Pielberg et al.   NATURE GENETICS

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE

Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins

(2008) Mathieu Provençal et al.   THROMBOSIS AND HAEMOSTASIS

The Haemostatic Role of Tissue Factor Pathway Inhibitor

(2007) James T.B. Crawley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expressed sequence tags (ESTs) from the salivary glands of the tick Amblyomma cajennense (Acari: Ixodidae)

(2007) Isabel F.C. Batista et al.   TOXICON