Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses

Potential of hydroxybenzoic acids from Graptopetalum paraguayense for inhibiting of herpes simplex virus DNA polymerase – metabolome profiling, molecular docking and quantum-chemical analysis

(2022) Nadezhda Todorova et al.   PHARMACIA

Biologically active polyphenolic compounds from Lespedeza bicolor

(2022) Darya V. Tarbeeva et al.   FITOTERAPIA

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

(2022) Miroslava Šudomová et al.   Viruses-Basel

Triterpenes and Phenolic Compounds from Euphorbia deightonii with Antiviral Activity against Herpes Simplex Virus Type-2

(2022) Muhammad Bello Saidu et al.   Plants-Basel

Insights into the Anti-inflammatory and Antiviral Mechanisms of Resveratrol

(2022) Xiangxiu Chen et al.   MEDIATORS OF INFLAMMATION

Dietary Polyphenol, Gut Microbiota, and Health Benefits

(2022) Xiaofei Wang et al.   Antioxidants

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance

(2021) Jayaraju Dheekollu et al.   CELL

Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice

(2021) Maimoona Bhutta et al.   Viruses-Basel

Polyphenols and Human Health: The Role of Bioavailability

(2021) Chiara Di Lorenzo et al.   Nutrients

Inactivation of Herpes Simplex Virus by Photosensitizing Anthraquinones Isolated from Heterophyllaea pustulata

(2021) M. Laura Mugas et al.   PLANTA MEDICA

Nutraceutical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways

(2021) Miroslava Šudomová et al.   Microorganisms

Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action

(2021) Yue Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Grape Canes from Typical Cultivars of Campania (Southern Italy) as a Source of High-Value Bioactive Compounds: Phenolic Profile, Antioxidant and Antimicrobial Activities

(2021) Giuseppe Squillaci et al.   MOLECULES

Cytomegalovirus (CMV) Infection and Latency

(2021) Christine M. O’Connor   Pathogens

Identification of Potential Inhibitors against Epstein–Barr Virus Nuclear Antigen 1 (EBNA1): An Insight from Docking and Molecular Dynamic Simulations

(2021) Shweta Jakhmola et al.   ACS Chemical Neuroscience

Cancers associated with human gammaherpesviruses

(2021) Kwun Wah Wen et al.   FEBS Journal

Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers

(2021) Miroslava Šudomová et al.   Viruses-Basel

Curcumin sensitizes Epstein‑Barr‑immortalized lymphoblastoid cell lines to inorganic arsenic toxicity

(2021) Macario Martínez‑Castillo et al.   Experimental and Therapeutic Medicine

Multifaceted Roles of ICP22/ORF63 Proteins in the Life Cycle of Human Herpesviruses

(2021) Ying Wu et al.   Frontiers in Microbiology

The Ethyl Acetate Subfraction of Polygonum cuspidatum Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis

(2021) Ching-Yi Yiu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Polyphenols and their potential role to fight viral diseases: An overview

(2021) María Fernanda Montenegro-Landívar et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Pathogenesis and virulence of herpes simplex virus

(2021) Shuyong Zhu et al.   Virulence

Nanoformulation Composed of Ellagic Acid and Functionalized Zinc Oxide Nanoparticles Inactivates DNA and RNA Viruses

(2021) Khaled AbouAitah et al.   Pharmaceutics

Antiviral Properties of Polyphenols from Plants

(2021) Katarzyna Chojnacka et al.   Foods

Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir – resistant herpes simplex virus 1 infection

(2020) Daniele Zendrini Rechenchoski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Human alpha and beta herpesviruses and cancer: passengers or foes?

(2020) František Golais et al.   FOLIA MICROBIOLOGICA

Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa

(2020) Danielle Vitali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Herpesviruses in Head and Neck Cancers

(2020) Mikołaj Wołącewicz et al.   Viruses-Basel

Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development

(2020) Jakub Treml et al.   Viruses-Basel

Dermatological manifestations of Epstein‐Barr virus systemic infection: a case report and literature review

(2020) Giulia Ciccarese et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

The mTOR inhibitor manassantin B reveals a crucial role of mTORC2 signaling in Epstein-Barr virus reactivation

(2020) Qian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Herpesvirus latency

(2020) Jeffrey I. Cohen   JOURNAL OF CLINICAL INVESTIGATION

Antiviral Potential of Spondias mombin L. Leaves Extract Against Herpes Simplex Virus Type-1 Replication Using In Vitro and In Silico Approaches

(2020) Emerson M. da S. Siqueira et al.   PLANTA MEDICA

Ginkgolic acid inhibits fusion of enveloped viruses

(2020) Ronen Borenstein et al.   Scientific Reports

Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro

(2020) San-Ying Wang et al.   JOURNAL OF MICROBIOLOGY

Lytic Induction Therapy against Epstein–Barr Virus-Associated Malignancies: Past, Present, and Future

(2020) Stephanie Pei Tung Yiu et al.   Cancers

Curcumin inhibits the formation of atherosclerosis in ApoE mice by suppressing cytomegalovirus activity in endothelial cells

(2020) Ya-li Lv et al.   LIFE SCIENCES

The structural basis of herpesvirus entry

(2020) Sarah A. Connolly et al.   NATURE REVIEWS MICROBIOLOGY

Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

(2020) Farid A. Badria et al.   MOLECULES

The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection

(2020) Yongqian Huang et al.   NEUROLOGICAL RESEARCH

Bioactivity of dietary polyphenols: The role of metabolites

(2019) Simon Vlad Luca et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol

(2019) Shuai Liu et al.   VIROLOGICA SINICA

The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus.

(2019) Daniele Zendrini Rechenchoski et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Anti-Herpetic, Anti-Dengue and Antineoplastic Activities of Simple and Heterocycle-Fused Derivatives of Terpenyl-1,4-Naphthoquinone and 1,4-Anthraquinone

(2019) Vicky Roa-Linares et al.   MOLECULES

Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets

(2019) Ying Xie et al.   Frontiers in Microbiology

Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis

(2019) He Li et al.   ANTIVIRAL RESEARCH

Polyphenols: A concise overview on the chemistry, occurrence, and human health

(2019) Alessandra Durazzo et al.   PHYTOTHERAPY RESEARCH

Congenital human cytomegalovirus infection and neurologic diseases in newborns

(2019) Xin-Yan Zhang et al.   CHINESE MEDICAL JOURNAL

Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

(2019) Raghavendhar R. Kotha et al.   MOLECULES

Psoromic Acid, a Lichen-Derived Molecule, Inhibits the Replication of HSV-1 and HSV-2, and Inactivates HSV-1 DNA Polymerase: Shedding Light on Antiherpetic Properties

(2019) Sherif T. S. Hassan et al.   MOLECULES

Hampering Herpesviruses HHV-1 and HHV-2 Infection by Extract of Ginkgo biloba (EGb) and Its Phytochemical Constituents

(2019) Marta Sochocka et al.   Frontiers in Microbiology

Emodin Inhibits EBV Reactivation and Represses NPC Tumorigenesis

(2019) Chung-Chun Wu et al.   Cancers

Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB

(2019) Liqiong Ding et al.   BIOCHEMICAL PHARMACOLOGY

Bioactive constituents of Lindernia crustacea and its anti-EBV effect via Rta expression inhibition in the viral lytic cycle

(2019) Yu-Chi Tsai et al.   JOURNAL OF ETHNOPHARMACOLOGY

Acyclovir in the Treatment of Herpes Viruses – a Review

(2018) Katarzyna Klysik et al.   CURRENT MEDICINAL CHEMISTRY

Multifunctional Tannic Acid/Silver Nanoparticle-Based Mucoadhesive Hydrogel for Improved Local Treatment of HSV Infection: In Vitro and In Vivo Studies

(2018) Emilia Szymańska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential cancer chemopreventive and anticancer constituents from the fruits of Ficus hispida L.f. (Moraceae)

(2018) Jie Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Study on antiviral activities, drug-likeness and molecular docking of bioactive compounds of Punica granatum L. to Herpes simplex virus - 2 (HSV-2)

(2018) Jagadeesan Arunkumar et al.   MICROBIAL PATHOGENESIS

Turmeric (Curcuma longa ) and its major constituent (curcumin) as nontoxic and safe substances: Review

(2018) Vahid Soleimani et al.   PHYTOTHERAPY RESEARCH

Epstein–Barr Virus and Cancer

(2018) Paul J. Farrell   Annual Review of Pathology-Mechanisms of Disease

Synergistic effect of resveratrol and HSV-TK/GCV therapy on murine hepatoma cells

(2018) Jianyong Xiao et al.   CANCER BIOLOGY & THERAPY

Antiviral Therapies for Herpesviruses: Current Agents and New Directions

(2018) Claudette L. Poole et al.   CLINICAL THERAPEUTICS

Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

(2018) Giuseppe Annunziata et al.   Viruses-Basel

How Host Specific Are Herpesviruses? Lessons from Herpesviruses Infecting Wild and Endangered Mammals

(2018) Walid Azab et al.   Annual Review of Virology

Antiviral activity of metal chelates of caffeic acid and similar compounds towards herpes simplex, VSV-Ebola pseudotyped and vaccinia viruses

(2018) Jeffrey Langland et al.   ANTIVIRAL RESEARCH

Clinical Features of Varicella-Zoster Virus Infection

(2018) Peter Kennedy et al.   Viruses-Basel

Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections

(2017) Barbara Rajtar et al.   FOOD AND CHEMICAL TOXICOLOGY

UPLC–PDA–ESI–qTOF-MS profiling and potent anti-HSV-II activity of Eucalyptus sideroxylon leaves

(2017) Mona M. Okba et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Semisynthesis of (−)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein–Barr Virus Lytic Replication

(2017) Yongsheng Lin et al.   JOURNAL OF NATURAL PRODUCTS

Hibiscus sabdariffa L. and Its Bioactive Constituents Exhibit Antiviral Activity against HSV-2 and Anti-enzymatic Properties against Urease by an ESI-MS Based Assay

(2017) Sherif T. S. Hassan et al.   MOLECULES

Correction: Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV

(2017) David M. J. Houston et al.   PLoS One

Herpesviruses and Their Host Cells: A Successful Liaison

(2017) Barbara Adler et al.   TRENDS IN MICROBIOLOGY

Kaposi sarcoma herpesvirus-associated cancers and related diseases

(2017) Priscila H. Goncalves et al.   Current Opinion in HIV and AIDS

Anti-cytomegalovirus activity of the anthraquinone atanyl blue PRL

(2015) Zohaib Alam et al.   ANTIVIRAL RESEARCH

Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells

(2015) Feng-Yi Tang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Therapeutic Trial of Valganciclovir in Patients with Uveitis and Positive Epstein-Barr virus Early Antigen D IgG Titers

(2015) Sutasinee Boonsopon et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Bioactive natural products with anti-herpes simplex virus properties

(2015) Sherif T. S. Hassan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Curcumin inhibits human cytomegalovirus by downregulating heat shock protein 90

(2015) YALI LV et al.   Molecular Medicine Reports

Gammaherpesvirus Infection of Human Neuronal Cells

(2015) Hem Chandra Jha et al.   mBio

Varicella zoster virus infection

(2015) Anne A. Gershon et al.   Nature Reviews Disease Primers

The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions

(2015) Martin Michaelis et al.   NEOPLASIA

Ellagitannins as synergists of ACV on the replication of ACV-resistant strains of HSV 1 and 2

(2014) N. Vilhelmova-Ilieva et al.   ANTIVIRAL RESEARCH

Antiviral activity of topoisomerase II catalytic inhibitors against Epstein–Barr virus

(2014) Ting Wu et al.   ANTIVIRAL RESEARCH

Mechanism of curcumin resistance to human cytomegalovirus in HELF cells

(2014) Yali Lv et al.   BMC Complementary and Alternative Medicine

Protective effect of curcumin against cytomegalovirus infection in Balb/c mice

(2014) Yali Lv et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The pathogenesis of human cytomegalovirus

(2014) Paul Griffiths et al.   JOURNAL OF PATHOLOGY

Regulation of Herpesvirus Reactivation by Host MicroRNAs

(2014) Lori Frappier   JOURNAL OF VIROLOGY

Antiviral Activity of (+)-Rutamarin against Kaposi's Sarcoma-Associated Herpesvirus by Inhibition of the Catalytic Activity of Human Topoisomerase II

(2013) Bo Xu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo

(2010) Hai-Rong Xiong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity

(2008) Sebla B. Kutluay et al.   VIROLOGY