Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Review
Immunology
Wenting Li, Xiaobing Duan, Xingxing Chen, Meixiao Zhan, Haichuan Peng, Ya Meng, Xiaobin Li, Xian-Yang Li, Guofu Pang, Xiaohui Dou
Summary: Epstein-Barr virus (EBV) is the first tumor virus in humans, and nasopharyngeal carcinoma (NPC) accounts for 60% of new tumor cases caused by EBV worldwide annually. Over 90% of patients with undifferentiated NPC are infected with EBV. Immunotherapy has shown significant breakthroughs in the treatment of recurrent or metastatic NPC, providing a broad prospect for NPC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Xiandong Lin, Steven Wang, Keyu Lin, Jingfeng Zong, Qianlan Zheng, Ying Su, Tao Huang
Summary: This study investigated the roles of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression network and performing differential expression analysis. The Epstein-Barr virus (EBV) infection was found to be an important risk factor for NPC, with potential pathological differences between EBV+ and EBV- subtypes. The study identified differentially expressed coding and non-coding RNAs across different comparison groups, helping to elucidate genetic and epigenetic changes central to NPC progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Yudi Xiong, Mengting Yuan, Zhigang Liu, Jing Huang, Jianping Bi, Guoliang Pi, Ying Li, Yanping Li, Hanping He, Vivek Verma, Suqing Tian, Guang Han
Summary: This multicenter study examined the clinical characteristics of EBV-negative patients in the Chinese population and compared their long-term outcomes with EBV-positive patients. The study found that most EBV-negative patients were diagnosed in advanced stages and were more associated with the keratinizing subtype. Compared to EBV-negative patients, EBV-positive patients were more likely to experience local recurrence, but there was no significant difference in mortality during the follow-up period. Additionally, EBV-positive NPC patients seemed to have better survival compared to EBV-negative NPC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Raja Pramanik, Shalabh Arora, Preity Sharma, Ahitagni Biswas, Baibaswata Nayak, Alok Thakar, Atul Sharma, Sampa Ghose
Summary: Nasopharyngeal carcinoma is not endemic in India but shows higher incidences in its North-Eastern regions. Detecting NPC early is challenging, and assessing plasma Epstein-Barr virus DNA load can help monitor disease status, treatment response, and future relapse risk in nonendemic NPC patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Virology
Yi Tian Png, Audrey Zhi Yi Yang, Mei Ying Lee, Magdalene Jahn May Chua, Chwee Ming Lim
Summary: The vast majority of the global population are asymptomatic carriers of Epstein-Barr Virus (EBV), which can lead to EBV-related cancers like Nasopharyngeal Carcinoma (NPC). NPC is highly prevalent in Southern China and Southeast Asia, with a lack of effective treatment for recurrent disease in some patients. Research on the role of Natural Killer (NK) cells in clearing EBV-infected cells and evasion by EBV in NPC is crucial for developing more effective therapies.
Article
Genetics & Heredity
Zijian Zhou, Kaifeng Zheng, Shao Zhou, Youxiong Yang, Jun Chen, Xiaofeng Jin
Summary: This article thoroughly reviews the specific action mechanisms of E3 ligases in nasopharyngeal carcinoma (NPC) signaling pathways and discusses their functional relationship with Epstein-Barr virus (EBV). It also describes the current progress and limitations of targeted therapies against E3 ligases in NPC.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Medicine, General & Internal
Ruo-Wen Xiao, Fang Wang, Tong -Min Wang, Jiang -Bo Zhang, Zi-Yi Wu, Chang-Mi Deng, Ying Liao, Ting Zhou, Da -Wei Yang, Si-Qi Dong, Wen-Qiong Xue, Yong-Qiao He, Xiao-Hui Zheng, Xi-Zhao Li, Pei -Fen Zhang, Shao-Dan Zhang, Ye -Zhu Hu, Yu-Ying Liu, Yun-Fei Xia, Song Gao, Jian-Bing Mu, Lin Feng, Wei-Hua Jia
Summary: This study identified rare missense mutations in the POLN gene that are associated with familial NPC risk. Experimental studies demonstrated that these mutations impair the protein stability and expression levels of POLN, leading to a compromised ability to promote EBV lytic replication and host cell proliferation.
Article
Virology
Kena Lin, Zhiwen Zeng, Xueqi Li, Wenjie Chen, Dongfeng Lin, Shanghang Xie, Zhicong Wu, Mengmeng Li, Sumei Cao, Jinlin Du
Summary: This study investigated the association between hypertension and Epstein-Barr virus (EBV) reactivation. It found that hypertension increased the risk of EBV reactivation, while beta-blockers and angiotensin converting enzyme inhibitors (ACEIs) were associated with a reduced risk of EBV reactivation.
Article
Biochemistry & Molecular Biology
Yong-Qiao He, Ting Zhou, Da-Wei Yang, Yi-Jing Jia, Lei-Lei Yuan, Wen-Li Zhang, Tong-Min Wang, Ying Liao, Wen-Qiong Xue, Jiang-Bo Zhang, Xiao-Hui Zheng, Xi-Zhao Li, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Fang Wang, William C. Cho, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: Oral Epstein-Barr virus (EBV) DNA load is a non-invasive predictor that can be used for prognostic evaluation and risk stratification in patients with nasopharyngeal carcinoma (NPC).
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Beatrice M. Muriuki, Catherine S. Forconi, Erastus K. Kirwa, Titus K. Maina, Bonface O. Ariera, Jeffrey A. Bailey, Anita Ghansah, Ann M. Moormann, John M. Ong'echa
Summary: This study investigated the association between KIR3DL1 and KIR3DS1 genotypes and endemic Burkitt lymphoma (eBL). The results showed no significant difference in these genotypes between eBL patients and healthy controls, suggesting that the pathogenesis of eBL may not simply involve variations in these genotypes.
Article
Chemistry, Physical
Mengran Guo, Xing Duan, Xingchen Peng, Zhaohui Jin, Hai Huang, Wen Xiao, Qian Zheng, Yongqi Deng, Na Fan, Kepan Chen, Xiangrong Song
Summary: In this study, a lipid-based LMP2-mRNA vaccine was developed and shown to effectively express LMP2 and stimulate antigen-specific T-cell responses in cell assays. It significantly inhibited tumor growth in an LMP2-expressing tumor model after three doses of vaccination.
Review
Biochemistry & Molecular Biology
Li-Jen Liao, Wan-Lun Hsu, Chi-Ju Chen, Yen-Ling Chiu
Summary: Nasopharyngeal carcinoma is endemic in southern Asia and this article describes the molecular abnormalities in NPC and potential molecular mechanisms for future therapy. It provides an up-to-date review on the molecular pathways of NPC, improving our understanding of the disease and highlighting areas for further research.
Article
Oncology
Waruiru Mburu, Susan S. Devesa, David Check, Meredith S. Shiels, Sam M. Mbulaiteye
Summary: Burkitt lymphoma (BL), an aggressive B-cell lymphoma, has shown three age-specific incidence peaks worldwide. A study analyzing BL cases from the US National Cancer Institute's SEER program between 1973 and 2005 and SEER 22 between 2000 and 2019 revealed varying age-specific incidence rates and temporal trends. The overall incidence rate of BL was 3.96/million person-years with a male-to-female ratio of 2.85:1. BL rates were higher among Hispanic and White individuals compared to Black individuals. Survival rates improved between 2000 and 2019. This data suggests changes in etiological factors or diagnosis for BL.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Yung-Hsuan Chen, Sheng-Dean Luo, Shao-Chun Wu, Ching-Nung Wu, Tai-Jan Chiu, Yu-Ming Wang, Yao-Hsu Yang, Wei-Chih Chen
Summary: The study found that long-latent recurrence of nasopharyngeal carcinoma is not rare and is associated with poor survival outcomes. Most patients had early-stage primary cancer and a higher percentage of local recurrence. Regular follow-up for early detection of long-latent recurrence is necessary.
Article
Oncology
Kwai Fung Hui, Tsz Fung Chan, Wanling Yang, Jiangshan Jane Shen, Ki Pui Lam, Hin Kwok, Pak C. Sham, Sai Wah Tsao, Dora L. Kwong, Maria Li Lung, Alan Kwok Shing Chiang
INTERNATIONAL JOURNAL OF CANCER
(2019)
Review
Oncology
Kwai Fung Hui, Stephanie Pei Tung Yiu, Kam Pui Tam, Alan Kwok Shing Chiang
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Stephanie Pei Tung Yiu, Kwai Fung Hui, Christian Muenz, Kwok-Wai Lo, Sai Wah Tsao, Richard Yi Tsun Kao, Dan Yang, Alan Kwok Shing Chiang
Article
Immunology
Janice K. P. Lam, Tarik Azzi, K. F. Hui, Aikha M. G. Wong, Donal McHugh, Nicole Caduff, K. H. Chan, Christian Munz, Alan K. S. Chiang
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biology
Donal McHugh, Renier Myburgh, Nicole Caduff, Michael Spohn, Yik Lim Kok, Christian W. Keller, Anita Murer, Bithi Chatterjee, Julia Ruehl, Christine Engelmann, Obinna Chijioke, Isaak Quast, Mohaned Shilaih, Victoria P. Strouvelle, Kathrin Neumann, Thomas Menter, Stephan Dirnhofer, Janice Kp Lam, Kwai F. Hui, Simon Bredl, Erika Schlaepfer, Silvia Sorce, Andrea Zbinden, Riccarda Capaul, Jan D. Luenemann, Adriano Aguzzi, Alan K. S. Chiang, Werner Kempf, Alexandra Trkola, Karin J. Metzner, Markus G. Manz, Adam Grundhoff, Roberto F. Speck, Christian Muenz
LIFE SCIENCE ALLIANCE
(2020)
Article
Microbiology
Jin Hua Liang, Chong Wang, Stephanie Pei Tung Yiu, Bo Zhao, Rui Guo, Benjamin E. Gewurz
Summary: EBV infection is associated with various cancers, with CTPS1 and CTPS2 potentially playing important roles in EBV-infected B cells. Lack of CTPS1 can impact EBV DNA synthesis, while deficiency of both CTPS1 and CTPS2 leads to stronger phenotypes, suggesting CTPS1/2 as potential therapeutic targets for EBV-driven lymphoproliferative disorders.
Article
Cell Biology
Stephanie Pei Tung Yiu, Rui Guo, Cassie Zerbe, Michael P. Weekes, Benjamin E. Gewurz
Summary: The Epstein-Barr virus (EBV) has strategies to evade intrinsic antiviral responses by using nuclear membrane-less replication compartments (RCs) for its lytic cycle amplification. This study reveals that EBV depletes the cohesin SMC5/6, which plays important roles in chromosome maintenance and DNA damage repair. Moreover, the tegument protein BNRF1 targets SMC5/6 complexes, affecting RC formation and encapsidation. This research highlights the roles of SMC5/6 as an immune sensor and restriction factor in the context of human herpesvirus RC and provides implications for understanding the pathogenesis of EBV-associated cancers.
Article
Biochemistry & Molecular Biology
Stephanie Pei Tung Yiu, Cassie Zerbe, David Vanderwall, Edward L. Huttlin, Michael P. Weekes, Benjamin E. Gewurz
Summary: Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis, and is associated with 200,000 cancers/year. Our study created a map of EBV-host and EBV-EBV interactions in B cells undergoing EBV replication, revealing conserved herpesvirus versus EBV-specific host cell targets. We identified the viral protein BILF1 as a novel therapeutic target and found that it triggers MAVS packaging into mitochondrial-derived vesicles and lysosomal proteolysis.
Review
Oncology
Mike Dorothea, Jia Xie, Stephanie Pei Tung Yiu, Alan Kwok Shing Chiang
Summary: This review summarizes the oncogenic roles of Epstein-Barr virus (EBV) lytic proteins, which are expressed during the latent and lytic replication cycles of the virus, and categorizes them based on the cancer hallmarks displayed. The oncogenic properties of several EBV lytic proteins are postulated by comparing the evolutionary conserved oncogenic mechanisms in other herpesviruses and oncoviruses.
Meeting Abstract
Oncology
Alan K. S. Chiang, Stephanie P. T. Yiu, Kwai F. Hui, Chung K. Choi, Richard Y. T. Kao, Dan Yang
