The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases

The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging

(2022) Stephany Francisco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of nutrition in muscle health of community‐dwelling older adults: evidence‐based expert consensus from Asian Working Group for Sarcopenia

(2022) Liang‐Kung Chen et al.   Journal of Cachexia Sarcopenia and Muscle

miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR

(2022) Paula Ketilly Nascimento Alves et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elevated mir-145-5p is associated with skeletal muscle dysfunction and triggers apoptotic cell death in C2C12 myotubes

(2022) Jing Jin et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Inducible deletion of Raptor and mTOR from adult skeletal muscle impairs muscle contractility and relaxation

(2022) Martina Baraldo et al.   JOURNAL OF PHYSIOLOGY-LONDON

mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy

(2022) Mengqi Liu et al.   Metabolites

A Novel TP53 Gene Mutation Sustains Non-Small Cell Lung Cancer through Mitophagy

(2022) Yuanli Wang et al.   Cells

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

(2021) Wenjun Wang et al.   Nature Communications

Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

(2021) Roberta Sartori et al.   Nature Communications

Non-Coding RNAs in the Transcriptional Network That Differentiates Skeletal Muscles of Sedentary from Long-Term Endurance- and Resistance-Trained Elderly

(2021) Paola De Sanctis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy

(2021) Hong-Wen Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosome biogenesis: Regulation and functions

(2021) Chonglin Yang et al.   JOURNAL OF CELL BIOLOGY

mTORC1 promotes cell growth via m6A-dependent mRNA degradation

(2021) Sungyun Cho et al.   MOLECULAR CELL

The mTOR–Autophagy Axis and the Control of Metabolism

(2021) Nerea Deleyto-Seldas et al.   Frontiers in Cell and Developmental Biology

Activation of Akt–mTORC1 signalling reverts cancer‐dependent muscle wasting

(2021) Alessia Geremia et al.   Journal of Cachexia Sarcopenia and Muscle

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

(2020) Sara Peixoto da Silva et al.   Journal of Cachexia Sarcopenia and Muscle

Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly

(2020) Ailin Bian et al.   BMC MUSCULOSKELETAL DISORDERS

PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy

(2020) Christian U Oeing et al.   CIRCULATION RESEARCH

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors

(2020) Anjali Bajpai et al.   Disease Models & Mechanisms

MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway

(2020) Kai-Yi Song et al.   Cell Death & Disease

Autophagy and metabolism

(2020) Pei‐Wen Lin et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

(2020) Daniel J. Ham et al.   Nature Communications

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

(2019) Mark J. Ranek et al.   NATURE

Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism

(2019) Xiawei Cheng et al.   MOLECULAR CELL

mTOR controls embryonic and adult myogenesis via mTORC1

(2019) Nathalie Rion et al.   DEVELOPMENT

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

(2019) Huibin Tang et al.   AGING CELL

RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells

(2019) Xianming Ding et al.   Autophagy

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program

(2019) Chintan K. Kikani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia

(2019) Giselle A. Joseph et al.   MOLECULAR AND CELLULAR BIOLOGY

Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults

(2019) Justin Chew et al.   Journal of Nutrition Health & Aging

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men

(2019) Nima Gharahdaghi et al.   Journal of Cachexia Sarcopenia and Muscle

Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles

(2019) Chiao-Nan Chen et al.   GeroScience

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

(2018) Ji-Man Park et al.   Autophagy

The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming

(2018) Hong-Wen Tang et al.   Cell Metabolism

Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice

(2018) Luchu Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease

(2018) Peter Feige et al.   Cell Stem Cell

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

(2018) Wei Wan et al.   MOLECULAR CELL

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

(2017) Wei Wan et al.   MOLECULAR CELL

Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17

(2017) Xiawei Cheng et al.   MOLECULAR CELL

Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway

(2017) Jingjing Fan et al.   Oncotarget

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study

(2016) James C Yao et al.   LANCET

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

mTORC1 and mTORC2 in cancer and the tumor microenvironment

(2016) L C Kim et al.   ONCOGENE

Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling

(2016) Xiangzheng Chen et al.   Journal of Cachexia Sarcopenia and Muscle

Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer

(2016) Eva Pigna et al.   Scientific Reports

mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration

(2015) Pengpeng Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Muscle as a “Mediator” of Systemic Metabolism

(2015) Kedryn K. Baskin et al.   Cell Metabolism

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

(2015) M. J. Munson et al.   EMBO JOURNAL

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

Cachexia: The last illness

(2015) Corie Lok   NATURE

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

(2015) Guowu Hu et al.   NATURE CELL BIOLOGY

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation

(2015) Jae-Woong Chang et al.   Nature Communications

Genetic interactions betweenDrosophila melanogasterAtg1 and paxillin reveal a role for paxillin in autophagosome formation

(2014) Guang-Chao Chen et al.   Autophagy

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity

(2014) Debariya Dutta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice

(2014) Mitchell Barns et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of the mTORC1 Complex in Satellite Cell Activation by RNA-Induced Mitochondrial Restoration: Dual Control of Cyclin D1 through MicroRNAs

(2014) S. Jash et al.   MOLECULAR AND CELLULAR BIOLOGY

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2014) Jamie L. Barger et al.   PLoS One

Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia

(2013) Fabio Penna et al.   AMERICAN JOURNAL OF PATHOLOGY

Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site

(2013) Ikuko Koyama-Honda et al.   Autophagy

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

(2013) Hai-Xin Yuan et al.   Autophagy

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

Atg9 Interacts with dTRAF2/TRAF6 to Regulate Oxidative Stress-Induced JNK Activation and Autophagy Induction

(2013) Hong-Wen Tang et al.   DEVELOPMENTAL CELL

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia

(2013) Melissa J. Puppa et al.   FASEB JOURNAL

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Sarcopenia in older adults

(2012) Jeremy D. Walston   CURRENT OPINION IN RHEUMATOLOGY

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

Unraveling the role of myosin in forming autophagosomes

(2011) Hong-Wen Tang et al.   Autophagy

MicroRNAs in skeletal myogenesis

(2011) Yejing Ge et al.   CELL CYCLE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Everolimus for Advanced Pancreatic Neuroendocrine Tumors

(2011) James C. Yao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse

(2011) James P. White et al.   PLoS One

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy

(2010) Hong-Wen Tang et al.   EMBO JOURNAL

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis

(2010) Yuting Sun et al.   JOURNAL OF CELL BIOLOGY

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

(2009) Yejing Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Phase III Study to Evaluate Temsirolimus Compared With Investigator's Choice Therapy for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

(2009) Georg Hess et al.   JOURNAL OF CLINICAL ONCOLOGY

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY