- Home
- Publications
- Publication Search
- Publication Details
Title
mTORC1 promotes cell growth via m6A-dependent mRNA degradation
Authors
Keywords
mTORC1, S6K1, m, A mRNA modification, mRNA stability, MXD2, cMyc, YTHDF readers, eIF4A, WTAP, Protein translation
Journal
MOLECULAR CELL
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-03-23
DOI
10.1016/j.molcel.2021.03.010
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy
- (2021) Hong-Wen Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacological Inhibition of the RNA m6a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia
- (2020) Konstantinos Tzelepis et al. BLOOD
- m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
- (2020) Huilin Huang et al. CANCER CELL
- A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
- (2020) Sara Zaccara et al. CELL
- RNA modifications regulating cell fate in cancer
- (2019) Sylvain Delaunay et al. NATURE CELL BIOLOGY
- Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis
- (2019) Haritha Mathsyaraja et al. GENES & DEVELOPMENT
- WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
- (2019) Yunhao Chen et al. Molecular Cancer
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming
- (2018) Hong-Wen Tang et al. Cell Metabolism
- Wilms’ tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability
- (2018) Jingyuan Tang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins
- (2018) Deepak P. Patil et al. TRENDS IN CELL BIOLOGY
- Renal disease in tuberous sclerosis complex: pathogenesis and therapy
- (2018) Hilaire C. Lam et al. Nature Reviews Nephrology
- eIF4A inhibition: ready for primetime?
- (2018) Tyler A. Cunningham et al. Oncotarget
- Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue
- (2017) Ashley M. Kopec et al. JOURNAL OF NEUROSCIENCE METHODS
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma
- (2017) Yari Ciribilli et al. Oncotarget
- The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
- (2016) Shuibin Lin et al. MOLECULAR CELL
- Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
- (2016) Xiang Wang et al. NATURE
- Reversible methylation of m6Am in the 5′ cap controls mRNA stability
- (2016) Jan Mauer et al. NATURE
- Translational control by 5'-untranslated regions of eukaryotic mRNAs
- (2016) A. G. Hinnebusch et al. SCIENCE
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
- (2016) I. Ben-Sahra et al. SCIENCE
- Messenger RNA modifications: Form, distribution, and function
- (2016) W. V. Gilbert et al. SCIENCE
- A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways
- (2015) Ana P Gomes et al. CURRENT OPINION IN BIOTECHNOLOGY
- Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
- (2015) Bastian Linder et al. NATURE METHODS
- mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation
- (2015) Jae-Woong Chang et al. Nature Communications
- Rapamycin: One Drug, Many Effects
- (2014) Jing Li et al. Cell Metabolism
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- (2014) Xiao-Li Ping et al. CELL RESEARCH
- The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
- (2014) Alfredo Csibi et al. CURRENT BIOLOGY
- WTAP is a novel oncogenic protein in acute myeloid leukemia
- (2014) H Bansal et al. LEUKEMIA
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Gene expression regulation mediated through reversible m6A RNA methylation
- (2014) Ye Fu et al. NATURE REVIEWS GENETICS
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
- (2014) Schraga Schwartz et al. Cell Reports
- PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast
- (2014) Shaun Webb et al. GENOME BIOLOGY
- mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
- (2013) Kenta Masui et al. Cell Metabolism
- The multifaceted role of mTORC1 in the control of lipid metabolism
- (2013) Stéphane J H Ricoult et al. EMBO REPORTS
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
- (2013) M. Pourdehnad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nutrient signaling to mTOR and cell growth
- (2013) Jenna L. Jewell et al. TRENDS IN BIOCHEMICAL SCIENCES
- MYC on the Path to Cancer
- (2012) Chi V. Dang CELL
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- ViennaRNA Package 2.0
- (2011) Ronny Lorenz et al. Algorithms for Molecular Biology
- MEME-ChIP: motif analysis of large DNA datasets
- (2011) Philip Machanick et al. BIOINFORMATICS
- T2 weighted MRI for assessing renal lesions in transgenic mouse models of tuberous sclerosis
- (2011) Maria Kalogerou et al. EUROPEAN JOURNAL OF RADIOLOGY
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
- (2011) Hongkai Ji et al. PLoS One
- A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA
- (2011) Susanne Kruse et al. Scientific Reports
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
- (2010) Boyi Gan et al. CANCER CELL
- Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors
- (2010) Chelsey Woodrum et al. Journal of Translational Medicine
- Control of Cell Survival and Proliferation by Mammalian Eukaryotic Initiation Factor 4B
- (2010) D. Shahbazian et al. MOLECULAR AND CELLULAR BIOLOGY
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models
- (2009) Nancy Lee et al. BMC Pharmacology & Toxicology
- SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
- (2008) Xiaoju Max Ma et al. CELL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started