The VEGF/VEGFR Axis Revisited: Implications for Cancer Therapy

LncRNAs and the Angiogenic Switch in Cancer: Clinical Significance and Therapeutic Opportunities

(2022) Peace Mabeta et al.   Genes

Tumors resurrect an embryonic vascular program to escape immunity

(2022) Elisabeth J. M. Huijbers et al.   Science Immunology

How VEGF-A and its splice variants affect breast cancer development – clinical implications

(2022) Hivin Al Kawas et al.   CELLULAR ONCOLOGY

Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige

(2021) Subhashis Natua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alternative splicing: An important regulatory mechanism in colorectal carcinoma

(2021) Jianyi Wang et al.   MOLECULAR CARCINOGENESIS

eNOS and VEGF Variants Might Increase the Risk of Pancreatic Cancer

(2021) Hasan Dagmura et al.   Cytology and Genetics

A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties

(2021) Eleanor Star et al.   Oncogenesis

USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1

(2021) Xiu-wu Pan et al.   Cancer Cell International

Alternative RNA Splicing—The Trojan Horse of Cancer Cells in Chemotherapy

(2021) Nikolay Mehterov et al.   Genes

Role of VEGFs/VEGFR-1 Signaling and Its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models

(2020) Claudia Ceci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VEGF-A165b levels are reduced in breast cancer patients at primary diagnosis but increase after completion of cancer treatment

(2020) Maria Margarete Karsten et al.   Scientific Reports

Targeting the spliceosome machinery: A new therapeutic axis in cancer?

(2020) Beatrice Eymin   BIOCHEMICAL PHARMACOLOGY

Intussusceptive angiogenesis as a key therapeutic target for cancer therapy

(2020) Sekaran Saravanan et al.   LIFE SCIENCES

Overexpression of VEGF165 is associated with poor prognosis of cervical cancer

(2020) Kinjal A. Patel et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

VEGF-A splice variants bind VEGFRs with differential affinities

(2020) Spencer B. Mamer et al.   Scientific Reports

Splicing factors: Insights into their regulatory network in alternative splicing in cancer

(2020) Jun-Xian Du et al.   CANCER LETTERS

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

Alternative Splicing in Angiogenesis

(2019) Elizabeth Bowler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P-039Vascular endothelial growth factor (VEGF) splice isoforms may hold the key to targeting tumour angiogenesis in oesophageal cancer

(2018) F Mehedi   ANNALS OF ONCOLOGY

Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1

(2018) Cristina Failla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New Insights in Anti-Angiogenesis in Multiple Myeloma

(2018) Domenico Ribatti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop

(2018) Asma Boudria et al.   ONCOGENE

Biology and therapeutic implications of VEGF-A splice isoforms and single-nucleotide polymorphisms in colorectal cancer

(2017) Miriam Canavese et al.   INTERNATIONAL JOURNAL OF CANCER

Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma

(2016) S. E. Assouline et al.   BLOOD

VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans

(2016) M Kazemi et al.   CANCER GENE THERAPY

Effects of receptor tyrosine kinase inhibitors on VEGF165a- and VEGF165b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2

(2015) Joanne J Carter et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Phase I/II Multicenter, Open-Label Study of the Oral Histone Deacetylase Inhibitor Abexinostat in Relapsed/Refractory Lymphoma

(2015) A. M. Evens et al.   CLINICAL CANCER RESEARCH

Vascular endothelial growth factor: Therapeutic possibilities and challenges for the treatment of ischemia

(2015) Trevor D. Crafts et al.   CYTOKINE

Inhibition of phosphoinositide 3-kinase is associated with reduced angiogenesis and an altered expression of angiogenic markers in endothelioma cells

(2014) P. Mabeta   BIOMEDICINE & PHARMACOTHERAPY

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease

(2014) Ryosuke Kikuchi et al.   NATURE MEDICINE

Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia

(2014) R.P. Hulse et al.   NEUROBIOLOGY OF DISEASE

The VEGF pathway in lung cancer

(2013) Michalis Alevizakos et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Regulation of angiogenesis by PI3K signaling networks

(2013) Mariona Graupera et al.   EXPERIMENTAL CELL RESEARCH

Antiangiogenic VEGF Isoform in Inflammatory Myopathies

(2013) Nila Volpi et al.   MEDIATORS OF INFLAMMATION

The role of VEGF165b in pathophysiology

(2013) Maria Peiris-Pagès   Cell Adhesion & Migration

Inhibition of hemangioma development in a syngeneic mouse model correlates with bcl-2 suppression and the inhibition of Akt kinase activity

(2011) Peace Mabeta et al.   ANGIOGENESIS

Overexpression of VEGF 165 b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients With Systemic Sclerosis

(2011) Mirko Manetti et al.   CIRCULATION RESEARCH

VEGF as a Biomarker for Metastatic Uveal Melanoma in Humans

(2011) Vivian Barak et al.   CURRENT EYE RESEARCH

VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A

(2011) Raúl Catena et al.   Molecular Cancer

Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors

(2010) Helena Pavlakovic et al.   Annals of the New York Academy of Sciences

A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents

(2009) Peace Mabeta et al.   ANGIOGENESIS

Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling

(2009) Andrew N. Makanya et al.   ANGIOGENESIS

Pathways mediating VEGF-independent tumor angiogenesis

(2009) Napoleone Ferrara   CYTOKINE & GROWTH FACTOR REVIEWS

Molecular Diversity of VEGF-A as a Regulator of Its Biological Activity

(2009) Jeanette Woolard et al.   MICROCIRCULATION

VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy

(2008) A H R Varey et al.   BRITISH JOURNAL OF CANCER

The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice

(2008) E S Rennel et al.   BRITISH JOURNAL OF CANCER

Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity

(2008) H. Kawamura et al.   CANCER RESEARCH

Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165

(2008) Yan Zhang et al.   GROWTH FACTORS

Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma

(2008) Masatoshi Jinnin et al.   NATURE MEDICINE

VEGF121 promotes lymphangiogenesis in the sentinel lymph nodes of non-small cell lung carcinoma patients

(2007) Hideki Kawai et al.   LUNG CANCER