Journal
MOLECULAR CARCINOGENESIS
Volume 60, Issue 4, Pages 279-293Publisher
WILEY
DOI: 10.1002/mc.23291
Keywords
alternative splicing; colorectal carcinoma; regulation mechanism
Categories
Ask authors/readers for more resources
Alternative splicing produces various mRNA isoforms through different splicing patterns of pre-mRNAs, influencing biodiversity and biological processes. It has been reported to be involved in the tumorigenesis of colorectal carcinoma. Understanding alternative splicing is crucial for studying the development of colorectal cancer.
Alternative splicing (AS) is a process that produces various mRNA splicing isoforms via different splicing patterns of mRNA precursors (pre-mRNAs). AS is the primary mechanism for increasing the types and quantities of proteins to improve biodiversity and influence multiple biological processes, including chromatin modification, signal transduction, and protein expression. It has been reported that AS is involved in the tumorigenesis and development of colorectal carcinoma (CRC). In this review, we delineate the concept, types, regulatory processes, and technical advances of AS and focus on the role of AS in CRC initiation, progression, treatment, and prognosis. This summary of the current knowledge about AS will contribute to our understanding of CRC initiation and development. This study will help in the discovery of novel biomarkers and therapeutic targets for CRC prognosis and treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available