Article
Oncology
Lucas Eduardo Botelho de Souza, Fernanda Ursoli Ferreira, Carolina Hassibe Thome, Heloisa Brand, Maristela Delgado Orellana, Vitor Marcel Faca, Aparecida Maria Fontes, Dimas Tadeu Covas
Summary: Melanoma cells have the capability to activate an EMT-like program and acquire metastatic traits through distinct pathways induced by MSCs' secretome, both in mouse and human cells.
Article
Medicine, General & Internal
Maria Laggner, Gabriela Sanchez-Acosta, Claudia Kitzmuller, Dragan Copic, Florian Gruber, Lukas Matthaus Altenburger, Vera Vorstandlechner, Alfred Gugerell, Martin Direder, Katharina Klas, Daniel Bormann, Anja Peterbauer, Akira Shibuya, Barbara Bohle, Hendrik Jan Ankersmit, Michael Mildner
Summary: This study demonstrates that the secretome of g-irradiated peripheral blood mononuclear cells (PBMCsec) can alleviate allergic reactions by reducing the activation of mast cells and basophils. The findings suggest the potential use of PBMCsec as a treatment for allergies.
Article
Biochemistry & Molecular Biology
Dmitri Atiakshin, Andrey Kostin, Igor Buchwalow, Vera Samoilova, Markus Tiemann
Summary: This study investigates the expression and secretory pathways of proteases in MCs in melanoma. The development of melanoma leads to the appearance of specific protease pools in the tumor-associated MC population, which is crucial for understanding the pathogenesis, classification, and prognosis of melanoma, as well as evaluating the effectiveness of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Tiziana Annese, Roberto Tamma, Mariella Bozza, Alfredo Zito, Domenico Ribatti
Summary: c-Kit receptor is expressed and involved in various biological processes in mucosal mast cells, such as cell survival, proliferation, hematopoiesis, and melanogenesis. This study found that in melanoma, mast cells express and release SCF and c-Kit receptors, potentially regulating tumor progression through an autocrine/paracrine loop.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nahoko Tomonobu, Rie Kinoshita, Hidenori Wake, Yusuke Inoue, I. Made Winarsa Ruma, Ken Suzawa, Yuma Gohara, Ni Luh Gede Yoni Komalasari, Fan Jiang, Hitoshi Murata, Ken-ichi Yamamoto, I. Wayan Sumardika, Youyi Chen, Junichiro Futami, Akira Yamauchi, Futoshi Kuribayashi, Eisaku Kondo, Shinichi Toyooka, Masahiro Nishibori, Masakiyo Sakaguchi
Summary: The secretion of S100A8/A9 proteins plays a crucial role in promoting the cancer environment and cultivating premetastatic cancer sites, while the presence of HRG protein in the brain prevents the metastasis of melanoma cells. Clinical findings suggest that HRG protects the brain and lungs from melanoma metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Qi Zhang, Linbo Jin, Quanxin Jin, Qiang Wei, Mingyuan Sun, Qi Yue, Huan Liu, Fangfang Li, Honghua Li, Xiangshan Ren, Guihua Jin
Summary: The study found that DHA has inhibitory effects on the proliferation, migration, and metastasis of melanoma, and can also impact immune cells in the tumor microenvironment. This suggests that DHA may serve as a potential treatment for melanoma.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qiang Wang, Yuyan Pan, Liping Zhao, Fazhi Qi, Jiaqi Liu
Summary: Previous studies have shown that PTP1B plays different roles in various cancers, promoting malignant melanoma progression. High expression of PTP1B is associated with melanoma cell migration and invasion, providing a potential target for therapeutic intervention.
Article
Cell Biology
Qiong Yang, Yusi Wang, Mengshu Li, Zhi Wang, Jieming Zhang, Weiyu Dai, Miaomiao Pei, Linjie Hong, Yizhi Xiao, Hongsong Hu, Jiaying Li, Jianjiao Lin, Xiaosheng Wu, Yaying Chen, Miaojuan Huang, Aimin Li, Side Liu, Weimei Tang, Li Xiang, Jide Wang
Summary: This study reveals that overexpression of HMGA1 protein in gastric cancer cells is associated with worse patient survival, and it influences the growth and metastasis of gastric cancer cells by transactivating the expression of SUZ12 and CCDC43. Both HMGA1 and SUZ12/CCDC43 are highly expressed in cancer cells and positively correlated, suggesting their potential value as prognostic biomarkers for gastric cancer.
Article
Oncology
Tatjana Seitz, Christina Hackl, Kim Freese, Peter Dietrich, Abdo Mahli, Reinhard Manfred Thasler, Wolfgang Erwin Thasler, Sven Arke Lang, Anja Katrin Bosserhoff, Claus Hellerbrand
Summary: The study demonstrates that xanthohumol inhibits melanoma metastasis and significantly reduces liver metastases in a mouse model, suggesting it as a promising novel treatment for patients with metastatic melanoma.
Review
Oncology
Qiliang Yin, Xiumin Shi, Shijie Lan, Haofan Jin, Di Wu
Summary: Melanoma stem cells (MSCs) play a crucial role in tumor angiogenesis and metastasis, exhibiting multidrug resistance and immune evasion capabilities. Specific biomarkers such as CD133, CD271, etc., are key players in melanoma stem cells.
Article
Biochemistry & Molecular Biology
Xingchen Guo, Aili Fan, Xinyi Qi, Dong Liu, Jian Huang, Wenhan Lin
Summary: A study discovered that the EtOAc extract of a marine-derived fungus Aspergillus clavutus LZD32-24 has significant inhibitory activity against angiogenesis in a zebrafish model. They isolated 48 indolo-quinazoline alkaloids, including 21 new analogues. Among them, quinadoline B (QB) showed the strongest inhibitory activity in zebrafish embryos and human umbilical vein endothelial cells (HUVECs). Further investigation revealed that QB disrupted actin cytoskeletal organization by suppressing the ROCK/MYPT1/MLC2/coffin and FAK/Src signaling pathways, leading to the inhibition of angiogenesis. QB also inhibited new blood vessel formation in the chick chorioallantoic membrane (CAM) and suppressed melanoma cell metastasis in the lungs of mice. This study suggests that QB has potential as a lead compound for the development of new antiangiogenic agents to inhibit melanoma metastasis.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Jun Ouyang, Junqing Li, Dongwei Li, Jianlong Jiang, Tengfei Hao, Yujian Xia, Xiaofang Lu, Changhua Zhang, Yulong He
Summary: Gastric cancer is a common malignancy with a high mortality rate. This study found that overexpression of IGF2BP2 in gastric cancer tissues was significantly associated with poor survival. The study also demonstrated that IGF2BP2 promotes epithelial-mesenchymal transition (EMT) in gastric cancer by directly interacting with HMGA1 mRNA. These findings suggest that IGF2BP2 may play a crucial role in gastric cancer metastasis.
Article
Cell Biology
Urszula Hohmann, Christoph Walsleben, Chalid Ghadban, Frank Kirchhoff, Faramarz Dehghani, Tim Hohmann
Summary: In brain tumor, the interactions between tumor cells and glial cells have complex effects on tumor heterogeneity and progression. Phytocannabinoids can increase the size of tumor spheroids without affecting cell migration and cell death.
Article
Immunology
Qiao Liu, Lisha Wang, Huayu Lin, Zhiming Wang, Jialin Wu, Junyi Guo, Shuqiong Wen, Ling Ran, Zhengliang Yue, Xingxing Su, Qing Wu, Jianfang Tang, Zhirong Li, Li Hu, Lifan Xu, Lilin Ye, Qizhao Huang
Summary: Cytotoxic CD8(+) T cells are the main focus of anti-tumor immunity and immunotherapy research, but transferred tumor-specific CD8(+) T cells have limited effect on suppressing tumor growth. On the other hand, CD4(+) T cells play an important role in curtailing tumor metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yusuke Nakamura, Jun Kinoshita, Takahisa Yamaguchi, Tatsuya Aoki, Hiroto Saito, Toshihide Hamabe-Horiike, Shinichi Harada, Sachiyo Nomura, Noriyuki Inaki, Sachio Fushida
Summary: By suppressing cancer-associated fibroblasts (CAFs), Tranilast improved the immunosuppressive microenvironment in a mouse PM model and showed potential as a candidate drug for PM treatment.
Article
Biochemistry & Molecular Biology
Daniel Almansa, Hector Peinado, Raquel Garcia-Rodriguez, Alvaro Casadome-Perales, Carlos G. Dotti, Francesc X. Guix
Summary: Research showed that EVs from neural cells cultured for 14 days could reduce the reactivity of astrocytes, while EVs from cells cultured for 21 days did not have the same effect. These findings in an in vitro model provide insights for further evaluating potential in vivo effects and underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Oncology
Shuchen Liu, Alberto Benito-Martin, Phoebe Piloco, Catherine Liu, Paul Paik, Jason A. Spector, Fanny A. Pelissier Vatter, David Lyden, David M. Otterburn, Leslie Cohen, Olivier Elemento, Rohan Bareja, Leona Cohen-Gould, Samuel Calto, Kristy A. Brown
Article
Oncology
Alberto Carretero-Gonzalez, Marta Hergueta-Redondo, Sara Sanchez-Redondo, Pilar Ximenez-Embun, Luis Manso Sanchez, Eva Ciruelos Gil, Daniel Castellano, Guillermo de Velasco, Hector Peinado
Summary: Brain metastases occur in nearly 40% of advanced cancer patients and are associated with poor prognosis. Liquid biopsy using extracellular vesicles (EVs) as biomarkers allows for noninvasive monitoring of brain metastases. This study found that decreased STAT3 activation and increased PD-L1 levels in plasma circulating EVs are associated with brain metastases in melanoma patients.
Article
Biochemistry & Molecular Biology
Chen Yuan Kam, Ishani D. Singh, David G. Gonzalez, Catherine Matte-Martone, Paloma Sola, Guiomar Solanas, Julia Bonjoch, Edward Marsh, Karen K. Hirschi, Valentina Greco
Summary: A functional network of blood vessels is crucial for organ growth and homeostasis in live mice, but the mechanisms of vascular maturation and homeostasis are not fully understood. By tracking neonatal endothelial cells over time, researchers discovered that capillary plexus expansion is driven by vessel regression to optimize network perfusion. Neonatal endothelial cells rearrange and become stable in adulthood, while adult endothelial cells reactivate migration to assist vessel repair. Global ablation shows coordinated maintenance of the adult vascular architecture that allows for eventual network recovery. Additionally, neonatal remodeling and adult maintenance of the skin vascular plexus are regulated by temporally restricted VEGFR2 signaling. This study provides insights into the fundamental mechanisms underlying vascular maturation and adult homeostasis in vivo.
Article
Biochemistry & Molecular Biology
Alvaro Casadome-Perales, Sara Naya, Elisa Fernandez-Martinez, Bea G. Mille, Marta Guerrero-Valero, Hector Peinado, Francesc X. Guix, Carlos G. Dotti, Ernest Palomer
Summary: Ageing is associated with changes in neurons, including gene expression, mitochondrial function, membrane degradation and intercellular communication. However, neurons remain functional in elderly individuals due to the prevalence of survival mechanisms over death mechanisms. Extracellular vesicles (EVs) can signal both pro-toxicity and survival. In this study, the researchers found an age-dependent increase in CerS2 in cortical EVs, expressed by oligodendrocytes. Furthermore, they demonstrated that CerS2 is present in neurons through the uptake of oligodendrocyte-derived EVs. The study suggests that intercellular communication is altered in the ageing brain, promoting neuronal survival through the transfer of oligodendrocyte-derived EVs containing CerS2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Stefan Coombs, Christian T. Oakley, Weston Buehring, Jerry Arraut, Ran Schwarzkopf, Joshua C. Rozell
Summary: This study aimed to determine the relationship between hospital teaching status and patient-reported outcome measures following primary THA. Analysis of registry data showed that both preoperative and one year postoperative HOOS, JR scores were higher at non-teaching hospitals compared to major and minor teaching hospitals. The odds of achieving the minimum clinically important difference (MCID) in HOOS, JR scores were similar for non-teaching and minor teaching hospitals compared to major teaching hospitals.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Biochemistry & Molecular Biology
Shuchen Liu, Alberto Benito-Martin, Fanny A. Pelissier Vatter, Sarah Z. Hanif, Catherine Liu, Priya Bhardwaj, Praveen Sethupathy, Alaa R. Farghli, Phoebe Piloco, Paul Paik, Malik Mushannen, Xue Dong, David M. Otterburn, Leslie Cohen, Rohan Bareja, Jan Krumsiek, Leona Cohen-Gould, Samuel Calto, Jason A. Spector, Olivier Elemento, David C. Lyden, Kristy A. Brown
Summary: Breast adipose tissue-derived extracellular vesicles (EVs) from overweight or obese women can promote breast cancer cell proliferation and induce metabolic reprogramming. Several miRNAs enriched in these EVs are responsible for enhancing mitochondrial respiration and proliferation. This study reveals a new aspect of the obesity-breast cancer link and highlights the role of EVs in modulating tumor cell functions.
Article
Biotechnology & Applied Microbiology
Maria Isabel Gonzalez, Begona Gallardo, Carlos Ceron, Elena Aguilera-Jimenez, Marta Cortes-Canteli, Hector Peinado, Manuel Desco, Beatriz Salinas
Summary: This study presents an optimized approach for purifying exosomes from goat milk by combining physical isolation methods with biological treatment. The vesicles isolated with this novel strategy showed characteristics similar to exosomes and high homogeneity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)