Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms23168930
Keywords
mast cells; melanoma; tryptase; chymase; carboxypeptidases
Funding
- departmental startup fund of the Institute of Hematopathology, Hamburg, Germany
Ask authors/readers for more resources
This study investigates the expression and secretory pathways of proteases in MCs in melanoma. The development of melanoma leads to the appearance of specific protease pools in the tumor-associated MC population, which is crucial for understanding the pathogenesis, classification, and prognosis of melanoma, as well as evaluating the effectiveness of antitumor therapy.
Mast cells (MCs) produce a variety of mediators, including proteases-tryptase, chymase, and carboxypeptidases-which are important for the immune response. However, a detailed assessment of the mechanisms of biogenesis and excretion of proteases in melanoma has yet to be carried out. In this study, we present data on phenotype and secretory pathways of proteases in MCs in the course of melanoma. The development of melanoma was found to be accompanied by the appearance in the tumor-associated MC population of several pools with a predominant content of one or two specific proteases with a low content or complete absence of others. Elucidation of the molecular and morphological features of the expression of MC proteases in melanoma allows us a fresh perspective of the pathogenesis of the disease, and can be used to clarify MCs classification, the disease prognosis, and evaluate the effectiveness of ongoing antitumor therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available