Tumor-Specific CD4+ T Cells Restrain Established Metastatic Melanoma by Developing Into Cytotoxic CD4– T Cells

Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy

(2022) Myriam Ben Khelil et al.   Cancers

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

(2021) Jiali Yu et al.   NATURE MEDICINE

CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy

(2021) Jennifer R. Richardson et al.   Cancers

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

(2021) Jason M. Schenkel et al.   IMMUNITY

A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response

(2021) Kelli A. Connolly et al.   Science Immunology

Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection

(2021) Laura M. Snell et al.   NATURE IMMUNOLOGY

Progress and Challenges in Precise Treatment of Tumors With PD-1/PD-L1 Blockade

(2020) Youhai Jiang et al.   Frontiers in Immunology

Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

(2020) David Y. Oh et al.   CELL

A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma

(2020) Fathima Zumla Cader et al.   NATURE MEDICINE

The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes

(2020) Floris Dammeijer et al.   CANCER CELL

TGF-β suppresses type 2 immunity to cancer

(2020) Ming Liu et al.   NATURE

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

(2020) Sri Krishna et al.   SCIENCE

Unlocking the therapeutic potential of primary tumor-draining lymph nodes

(2019) Jossie Rotman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Systems Biology of Cancer Metastasis

(2019) Yasir Suhail et al.   Cell Systems

CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

(2019) Ryan Zander et al.   IMMUNITY

Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells

(2019) Assaf Magen et al.   Cell Reports

Th9 Cells Represent a Unique Subset of CD4 + T Cells Endowed with the Ability to Eradicate Advanced Tumors

(2018) Yong Lu et al.   CANCER CELL

CD4+ T cell-mediated rejection of MHC class II-positive tumor cells is dependent on antigen secretion and indirect presentation on host APCs

(2018) Ole Audun Werner Haabeth et al.   CANCER RESEARCH

Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma

(2018) Margaretha G.M. Roemer et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor Regression and Cure Depends on Sustained Th1 Responses

(2018) Min Dai et al.   JOURNAL OF IMMUNOTHERAPY

Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity

(2018) Marte Fauskanger et al.   Frontiers in Immunology

CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

(2017) Tomasz Ahrends et al.   IMMUNITY

Value of ablation therapy in the treatment of lung metastases

(2017) Han Qi et al.   Thoracic Cancer

CD4 + T Cell and NK Cell Interplay Key to Regression of MHC Class I low Tumors upon TLR7/8 Agonist Therapy

(2017) Elien M. Doorduijn et al.   Cancer Immunology Research

Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency

(2016) F. Zhao et al.   CANCER RESEARCH

Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis

(2016) Erin A. Marshall et al.   Molecular Cancer

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

New insights into type I interferon and the immunopathogenesis of persistent viral infections

(2015) Laura M Snell et al.   CURRENT OPINION IN IMMUNOLOGY

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection

(2015) Lifan Xu et al.   NATURE IMMUNOLOGY

Cutting Edge: Murine Cytomegalovirus Induces a Polyfunctional CD4 T Cell Response

(2014) R. Arens et al.   JOURNAL OF IMMUNOLOGY

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells

(2013) Inna V. Grishkan et al.   CELLULAR IMMUNOLOGY

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selection of CD8+PD-1+ Lymphocytes in Fresh Human Melanomas Enriches for Tumor-reactive T Cells

(2010) Takashi Inozume et al.   JOURNAL OF IMMUNOTHERAPY

Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection

(2010) W. W. Reiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

(2009) M. Ahmadzadeh et al.   BLOOD

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

(2009) Coreen M Beaumier et al.   NATURE MEDICINE

Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells

(2008) Naoko Imai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

(2008) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

(2008) Naomi N. Hunder et al.   NEW ENGLAND JOURNAL OF MEDICINE