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Title
Pyrimidine derivatives with antitubercular activity
Authors
Keywords
-
Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 246, Issue -, Pages 114946
Publisher
Elsevier BV
Online
2022-11-22
DOI
10.1016/j.ejmech.2022.114946
References
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- Tracking total spending on tuberculosis by source and function in 135 low-income and middle-income countries, 2000–17: a financial modelling study
- (2020) Yanfang Su et al. LANCET INFECTIOUS DISEASES
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- (2012) T. Basta et al. Open Biology
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- (2011) Sara Van Poecke et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2011) Martin Kögler et al. JOURNAL OF MEDICINAL CHEMISTRY
- Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1
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- (2009) Vincent A. Boyd et al. JOURNAL OF COMBINATORIAL CHEMISTRY
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