Novel inhibitors ofMycobacterium tuberculosisgrowth based on modified pyrimidine nucleosides and their analogues

Inhibition of Mycobacterium tuberculosis strains H37Rv and MDR MS-115 by a new set of C5 modified pyrimidine nucleosides

(2013) Eduard R. Shmalenyuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of a Selective Activity-Based Probe for Adenylating Enzymes: Profiling MbtA Involved in Siderophore Biosynthesis from Mycobacterium tuberculosis

(2012) Benjamin P. Duckworth et al.   ACS Chemical Biology

Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2′-‘up’ fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors

(2012) Neeraj Shakya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives

(2012) Elena Matyugina et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Evaluation of 6-Aza-2′-deoxyuridine Monophosphate Analogs as Inhibitors of Thymidylate Synthases, and as Substrates or Inhibitors of Thymidine Monophosphate Kinase in Mycobacterium tuberculosis

(2012) Martin Kögler et al.   CHEMISTRY & BIODIVERSITY

Natural Products as Leads for Tuberculosis Drug Development

(2012) Christine E. Salomon et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Adenylating Enzymes in Mycobacterium tuberculosis as Drug Targets

(2012) Benjamin P. Duckworth et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Tuberculosis: The drug development pipeline at a glance

(2012) Baptiste Villemagne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbocyclic nucleoside analogues: classification, target enzymes, mechanisms of action and synthesis

(2012) E S Matyugina et al.   RUSSIAN CHEMICAL REVIEWS

Human viral diseases: what is next for antiviral drug discovery?

(2012) Erik De Clercq   Current Opinion in Virology

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

(2011) Sara Van Poecke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs

(2011) Naveen C. Srivastav et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrimidine Salvage Pathway in Mycobacterium tuberculosis

(2011) A. D. Villela et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and Evaluation of 5-Substituted 2′-deoxyuridine Monophosphate Analogues As Inhibitors of Flavin-Dependent Thymidylate Synthase inMycobacterium tuberculosis

(2011) Martin Kögler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biologically important nucleosides: modern trends in biotechnology and application

(2011) Igor A. Mikhailopulo et al.   MENDELEEV COMMUNICATIONS

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

(2010) Olga Familiar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine Analogues as Potent and Selective Inhibitors of Human Mitochondrial Thymidine Kinase

(2010) Sara Van Poecke et al.   JOURNAL OF MEDICINAL CHEMISTRY

3′-Bromo Analogues of Pyrimidine Nucleosides as a New Class of Potent Inhibitors ofMycobacterium tuberculosis

(2010) Neeraj Shakya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Mycobacterial Replication by Pyrimidines Possessing Various C-5 Functionalities and Related 2′-Deoxynucleoside Analogues Using in Vitro and in Vivo Models

(2010) Naveen C. Srivastav et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modification of nucleic acids using [3 + 2]-dipolar cycloaddition of azides and alkynes

(2010) A. V. Ustinov et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

New Antituberculous Drugs in Development

(2010) Umesh G. Lalloo et al.   Current HIV/AIDS Reports

Cu(I)-Catalyzed Huisgen Azide−Alkyne 1,3-Dipolar Cycloaddition Reaction in Nucleoside, Nucleotide, and Oligonucleotide Chemistry

(2009) Franck Amblard et al.   CHEMICAL REVIEWS

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: Synthesis and in vitro anti-mycobacterial activity

(2008) Cécile Gasse et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exploring Acyclic Nucleoside Analogues as Inhibitors ofMycobacterium tuberculosisThymidylate Kinase

(2008) Olga Familiar et al.   ChemMedChem