β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis

Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance

(2021) Jiewu Huang et al.   Stem Cell Research & Therapy

A Novel Mechanism of Regulation for Exosome Secretion in the Diabetic Kidney

(2021) Ye Feng et al.   DIABETES

Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice

(2021) Hongyang Liu et al.   Frontiers in Cell and Developmental Biology

Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases

(2021) Toshio Hattori et al.   Biomedicines

Adiponectin in renal fibrosis

(2020) Huan Jing et al.   Aging-US

Osteopontin induces atrial fibrosis by activating Akt/GSK-3β/β-catenin pathway and suppressing autophagy

(2020) Rongjie Lin et al.   LIFE SCIENCES

The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activation

(2020) Mi Nam Lee et al.   Stem Cell Research

Injured tubular epithelial cells activate fibroblasts to promote kidney fibrosis through miR-150-containing exosomes

(2020) Han Guan et al.   EXPERIMENTAL CELL RESEARCH

Osteopontin: The Molecular Bridge between Fat and Cardiac–Renal Disorders

(2020) Elena Vianello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI

(2020) Tao-Tao Tang et al.   Science Advances

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

(2020) Jie Xu et al.   Frontiers in Pharmacology

Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating β-catenin signaling

(2020) Shan Zhou et al.   KIDNEY INTERNATIONAL

Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

(2019) Lin-Li Lv et al.   CELL DEATH AND DIFFERENTIATION

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

The role of extracellular vesicles in renal fibrosis

(2019) H. Jing et al.   Cell Death & Disease

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

(2019) Jinhua Miao et al.   AGING CELL

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis

(2019) Xi Liu et al.   KIDNEY INTERNATIONAL

Targeting renal fibrosis: Mechanisms and drug delivery systems

(2018) Madalina V. Nastase et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

Osteopontin as a novel substrate for the proprotein convertase 5/6 ( PCSK5 ) in bone

(2018) Betty Hoac et al.   BONE

The biology and role of CD44 in cancer progression: therapeutic implications

(2018) Chen Chen et al.   Journal of Hematology & Oncology

Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation

(2018) Lin-Li Lv et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective

(2018) Mia Krolikoski et al.   MATRIX BIOLOGY

Renal fibrosis: Primacy of the proximal tubule

(2018) Leslie S. Gewin   MATRIX BIOLOGY

Exosome Theranostics: Biology and Translational Medicine

(2018) Chuanjiang He et al.   Theranostics

The role of osteopontin in kidney diseases

(2018) Beata Kaleta   INFLAMMATION RESEARCH

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

(2018) John D. Klement et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury

(2018) Ruochen Qi et al.   Cell Death & Disease

HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation

(2018) Zuo-Lin Li et al.   KIDNEY INTERNATIONAL

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

(2017) Liyu He et al.   KIDNEY INTERNATIONAL

Progression of chronic kidney disease: too much cellular talk causes damage

(2017) Leslie Gewin et al.   KIDNEY INTERNATIONAL

Sustained Activation of Wnt/ -Catenin Signaling Drives AKI to CKD Progression

(2015) L. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Understanding the mechanisms of kidney fibrosis

(2015) Dong Zhou et al.   Nature Reviews Nephrology

Mutual Antagonism of Wilms' Tumor 1 and  -Catenin Dictates Podocyte Health and Disease

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication

(2013) Dong Zhou et al.   Scientific Reports

Epithelial-mesenchymal crosstalk alteration in kidney fibrosis

(2012) Marco Prunotto et al.   JOURNAL OF PATHOLOGY

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice

(2012) Dong Zhou et al.   KIDNEY INTERNATIONAL

Osteopontin is upregulated after mechanical brain injury and stimulates neurite growth from hippocampal neurons through β1 integrin and CD44

(2012) Stefan Plantman   NEUROREPORT

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Kaempferol regulates OPN–CD44 pathway to inhibit the atherogenesis of apolipoprotein E deficient mice

(2011) Hong-Bo Xiao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE