Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti‐tumor candidates

Designing anticancer combretastatin A-4 analogues with aggregation-induced emission characteristics

(2022) Rucheng Zhao et al.   Science China-Chemistry

Progress of tubulin polymerization activity detection methods

(2021) Ting Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel series of benzothiazepine derivatives as tubulin polymerization inhibitors with anti-tumor potency

(2021) Bin Wang et al.   BIOORGANIC CHEMISTRY

Pyrazoline derivatives as tubulin polymerization inhibitors with one hit for Vascular Endothelial Growth Factor Receptor 2 inhibition

(2021) Bing Yang et al.   BIOORGANIC CHEMISTRY

Exploring the cause of the dual allosteric targeted inhibition attaching to allosteric sites enhancing SHP2 inhibition

(2021) Ma Yangchun et al.   MOLECULAR DIVERSITY

Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay

(2021) Mohamad Allaw et al.   BIOMEDICINE & PHARMACOTHERAPY

Design, synthesis and biological evaluation of isoxazole-naphthalene derivatives as anti-tubulin agents

(2020) Guangcheng Wang et al.   Arabian Journal of Chemistry

Synergistic co-loading of vincristine improved chemotherapeutic potential of Pegylated liposomal doxorubicin against triple negative breast cancer and non-small cell lung cancer

(2020) Saikat Ghosh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

(2019) Kinsie E Arnst et al.   MEDICINAL RESEARCH REVIEWS

Microtubule-Targeting Drugs: More than Antimitotics

(2019) Roma Kaul et al.   JOURNAL OF NATURAL PRODUCTS

Targeted-nanoliposomal combretastatin A4 (CA-4) as an efficient antivascular candidate in the metastatic cancer treatment

(2019) Maryam Ebrahimi Nik et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Synthesis, Anticancer Activity and Molecular Modeling Studies of Novel Chalcone Derivatives Containing Indole and Naphthalene Moieties as Tubulin Polymerization Inhibitors

(2019) Guangcheng Wang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Tubulin inhibitors as novel anticancer agents: an overview on patents (2013-2018)

(2019) Kashif Haider et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Indole: A privileged scaffold for the design of anti-cancer agents

(2019) Yichao Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site

(2018) Ling Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and characterization of α -lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors

(2018) Hong-Yan Lin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

(E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction

(2018) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-mitotic therapies in cancer

(2018) Julia Tischer et al.   JOURNAL OF CELL BIOLOGY

Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer

(2017) C Hardin et al.   EXPERT OPINION ON PHARMACOTHERAPY

Recent Advances in Heterocyclic Tubulin Inhibitors Targeting the Colchicine Binding Site

(2016) Xiaoxin Wu et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors

(2015) Xuan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis, structure–activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors

(2013) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors

(2013) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Design, synthesis, biological evaluation and molecular modeling of novel 1,3,4-oxadiazole derivatives based on Vanillic acid as potential immunosuppressive agents

(2012) Jian-Feng Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Up-Regulation of Connective Tissue Growth Factor in Endothelial Cells by the Microtubule-Destabilizing Agent Combretastatin A-4

(2009) J. Samarin et al.   MOLECULAR CANCER RESEARCH