Article
Chemistry, Multidisciplinary
Adriana Ramona Memete, Florina Miere (Groza), Vasile Laslo, Cornelia Purcarea, Laura Vicas, Mariana Ganea, Angela Antonescu, Simona Ioana Vicas
Summary: The study aimed to develop a liposomal formulation containing black mulberry extract and assess its potential in healing normal human dermal fibroblasts (NHDF) in vitro using the scratch test. It was found that liposomes loaded with mulberry extract showed better efficacy in fibroblast wound closure compared to mulberry extracts.
APPLIED SCIENCES-BASEL
(2023)
Article
Cell & Tissue Engineering
Stefan Balko, Evan Kerr, Ed Buchel, Sarvesh Logsetti, Afshin Raouf
Summary: Stromal vascular fraction (SVF) cells and keratinocytes engage in a paracrine crosstalk during wound closure, resulting in a new cytokine profile that can be used to accelerate wound healing and initiate re-epithelialization.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, Research & Experimental
Wiem Elloumi, Asma Mahmoudi, Sergio Ortiz, Sabrina Boutefnouchet, Mohamed Chamkha, Sami Sayadi
Summary: The study demonstrated that Pistacia lentiscus distilled leaves extract and its two isolated glycosylated flavonoids have the potential to accelerate wound healing, reduce inflammation, and enhance collagen biosynthesis in wound tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Efstathios Giannakopoulos, Annita Katopodi, Michail Rallis, Konstantinos Politopoulos, Eleni Alexandratou
Summary: This study investigated the effectiveness of red light at 661 nm in accelerating wound healing using an in vitro wound model. The results showed that low power laser light at 661 nm promoted cell migration and proliferation, indicating its potential in accelerating wound healing. The study also found that ROS production and cellular orientation played important roles in the wound healing process.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Edward J. Calabrese, Gaurav Dhawan, Rachna Kapoor, Evgenios Agathokleous, Vittorio Calabrese
Summary: This article investigates the commonly observed hormetic dose responses in dermal wound healing, specifically focusing on cell viability, proliferation, and migration of human keratinocytes in in vitro studies. Hormetic responses can be induced by a wide range of substances, including endogenous agents, drugs, and plant derived extracts. The findings suggest that hormesis plays a fundamental role in wound healing and has important implications for agent screening, evaluation, and clinical strategies.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ting W. Yiu, Sara R. Holman, Xenia Kaidonis, Robert M. Graham, Siiri E. Iismaa
Summary: TG2 gene knockout mice were used to investigate the role of TG2 in wound healing. The study found that TG2 facilitates murine wound healing in a strain-dependent manner. The rate of wound healing was different between 129 and B6 mouse strains, correlating with TG2 abundance. TG2 was shown to promote integrin- and syndecan-mediated RhoA- and Rac1-activation in fibroblasts to promote efficient wound contraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ahmad Oryan, Esmat Alemzadeh, Soroush Mohammadi
Summary: This study investigated the use of curcumin nanomicelles as wound dressings and their effects on fibroblast migration and proliferation. The results showed that curcumin nanomicelles significantly improved wound contraction and increased the expression of growth factors. Histopathological analysis revealed improved tissue organization, angiogenesis, and re-epithelialization in the curcumin nanomicelles-treated burn wounds. Overall, curcumin nanomicelles could be a promising choice for burn wound treatment.
CONNECTIVE TISSUE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Masaya Yokota, Nicola Haeffner, Matthew Kassier, Matthias Brunner, Srikanth Mairpady Shambat, Fabian Brennecke, Janine Schniering, Ewerton Marques Maggio, Oliver Distler, Annelies Sophie Zinkernagel, Britta Maurer
Summary: The study revealed that Staphylococcus aureus affects dermal fibroblasts, leading to impaired tissue repair functions such as upregulation of pro-inflammatory cytokines and degradation of collagen. This impact is not limited to specific cell sources and affects key mechanisms of wound healing.
Article
Biochemistry & Molecular Biology
Vasileios Xanthis, Eleni Fitsiou, Georgia-Persephoni Voulgaridou, Athanasios Bogadakis, Katerina Chlichlia, Alex Galanis, Aglaia Pappa
Summary: Although mastic oil and its major components did not exhibit significant direct antioxidant activity, they were able to increase mRNA levels of antioxidant response genes, suggesting an indirect antioxidant activity. These substances showed beneficial effects on cell viability and protection against UVB or H2O2-induced oxidative damage, as well as promoting cell migration and wound closure in a dose-dependent manner. Overall, mastic essential oil may exert promising cytoprotective properties through indirect antioxidant mechanisms.
Article
Physiology
Peng Zhou, Vanessa Chrepa, Ioannis Karoussis, Michael A. Pikos, Georgios A. Kotsakis
Summary: This study found that an herbal extract compound-based oral rinse was cytocompatible to cells critical to oral wound healing and promoted fibroblast migration and differentiation, contrary to existing antiseptic rinses that lack selective cytotoxicity.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Physical
Yueyue Li, Weifeng Zhong, Junjie Wu, Yuan Jia, Zhonghua Chen, Kaiwen Zhang, Danyang Guo, Yifei Fu, Mengnan Chen, Weiwei Chen, Fan Tian, Xia Li, Hongji Zhang, Xiaojin Zhou, Feng-Lai Yuan
Summary: Recruiting key cells to regeneration sites is a promising strategy for promoting functional wound healing. Papillary fibroblasts, with central regulatory roles in skin appendage regeneration, can be recruited using Grass Carp Fishing multifunctional hydrogels, which deliver Lrig1 antibodies and IGF1 to the surface of these fibroblasts. Injectable self-healing multifunctional hydrogels, with sustained release of Lrig1 antibodies and IGF1, were shown to accelerate the migration and proliferation of Lrig1(+) fibroblasts and promote wound healing and skin regeneration.
Article
Veterinary Sciences
R. Latrach, N. Ben Chehida, A. Allous, H. Redid, A. Rejeb, H. Abdelmelek
Summary: The effects of WIFI exposure and the application of Pistacia lentiscus oil on wound healing were investigated in this study. It was found that WIFI exposure or lentisk oil application can promote collagen deposition and improve the overall condition of wounds. However, co-exposure to WIFI and lentisk oil extended the inflammatory phase of wound healing.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yue Zhi, Junyi Che, Haofang Zhu, Rui Liu, Yuanjin Zhao
Summary: In this study, a novel GA liposomes encapsulated microcapsules delivery system was developed for inflammatory wound repair. The GA liposomes could be controllably released from the microcapsules, promoting M2 macrophage polarization and regulating their responses in the inflammatory wound microenvironment. The results demonstrated that the GA liposomes encapsulated microcapsules delivery system exhibited anti-inflammatory and immunomodulatory effects for diabetic wound healing.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Wen-qing Tian, Si-yu Chen, Feng-ning Chuan, Wen-rui Zhao, Bo Zhou
Summary: TINAGL1 plays an important role in diabetic wound healing and its expression is regulated by high glucose. Administration of exogenous TINAGL1 can promote wound healing in diabetic mice. These findings provide new insights for the treatment of diabetic wounds.
Article
Computer Science, Software Engineering
A. Loddo, C. Di Ruberto, A. M. P. G. Vale, M. Ucchesu, J. M. Soares, G. Bacchetta
Summary: Image analysis is crucial for studying various topics in life sciences. This study presents software that performs image analysis for seed feature extraction and classification, demonstrating outstanding performance on seed datasets.
Article
Pharmacology & Pharmacy
Maria Manconi, Maryam Rezvani, Maria Letizia Manca, Elvira Escribano-Ferrer, Sara Fais, Germano Orru, Twan Lammers, Fabiano Asunis, Aldo Muntoni, Daniela Spiga, Giorgia De Gioannis
Summary: New intestinal health-promoting biotechnological nanovesicles were created by combining whey, a major environmental pollutant from cheese-making, with phospholipid, sodium hyaluronate, and dextrin. A consolidated and ecofriendly method was used to manufacture the vesicles, which were characterized by small size and negative surface charge. These vesicles were effectively internalized by Caco-2 cells and protected against oxidative stress. The findings suggest the potential of integrating biotechnology, nanomedicine, sustainability principles, and bio-circular economy for intestinal protection and health promotion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Clinical Neurology
Matteo Moro, Vito Paolo Pastore, Giorgia Marchesi, Paola Proserpio, Laura Tassi, Anna Castelnovo, Mauro Manconi, Giulia Nobile, Ramona Cordani, Steve A. A. Gibbs, Francesca Odone, Maura Casadio, Lino Nobili
Summary: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy that mainly occurs during sleep, while disorders of arousal (DOA) are sleep disorders with similar symptoms. This paper proposes a pipeline based on three-dimensional convolutional neural networks to accurately classify different SHE patterns and DOA with 80% accuracy using video recordings.
Article
Clinical Neurology
Simone B. Duss, Corrado Bernasconi, Anita Steck, Anne-Kathrin Brill, Mauro Manconi, Martijn Dekkers, Markus H. Schmidt, Claudio L. A. Bassetti
Summary: This study aimed to assess the impact of multiple sleep wake disturbances (SWD) on the risk of cardio-cerebrovascular events (CCE) and death in stroke patients. It found that the presence of multiple SWD increases the risk of CCE and death in stroke patients. Larger systematic studies are needed to evaluate the utility of the sleep burden index in risk stratification for patients in clinical practice.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Renata Sklenarova, Mohamad Allaw, Matteo Perra, Ines Castangia, Jana Frankova, Jose Luis Pedraz, Maria Letizia Manca, Maria Manconi
Summary: In this study, oleuropein and lentisk oil were co-loaded in various phospholipid vesicles to create a formulation with anti-inflammatory and wound healing effects. The vesicles showed small size, uniform dispersion, high negative charge, and high loading capacity for oleuropein and lentisk oil. The co-loading of these compounds inhibited the production of inflammatory markers and promoted wound healing in vitro. This co-loading strategy in natural-based phospholipid vesicles holds promise for treating skin disorders.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Mohammad Firoznezhad, Rita Abi-Rached, Federica Fulgheri, Matteo Aroffu, Francisco-Javier Leyva-Jimenez, Maria de la Luz Cadiz Gurrea, Maria Cristina Meloni, Francesco Corrias, Elvira Escribano-Ferrer, Jose Esteban Peris, Maria Letizia Manca, Maria Manconi
Summary: In this study, an antioxidant phytocomplex was extracted from the flowers of E. amoenum and loaded into liposomes. The liposomes were enriched with different bioadhesive polymers individually or in combination. The physico-chemical properties of the prepared vesicles were measured, as well as their stability on storage. The biocompatibility and the ability of the formulations to protect keratinocytes and promote cell migration were evaluated in vitro.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Green & Sustainable Science & Technology
Matteo Perra, Francisco-Javier Leyva-Jimenez, Maria Letizia Manca, Maria Manconi, Hiba N. Rajha, Isabel Borras-Linares, Antonio Segura-Carretero, Jesus Lozano-Sanchez
Summary: The aim of this study was to optimize the recovery of phenolic compounds from Cannonau grape pomaces using Pressurized Liquid Extraction (PLE). Response Surface Methodology (RSM) based on a Central Composite Design 23 model was used to perform PLE experiments. The results showed that the optimum values for phenolics extraction were 130 degrees C, 55% ethanol, and 22 min. The proposed experimental model proved to be a valuable alternative method for the extraction of bioactive compounds from wine-making by-products.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Parasitology
Nonnis Francesca, Tamponi Claudia, Tosciri Gabriele, Manconi Maria, Pudda Flavia, Cabras Pierangela, Dessi Giorgia, Scala Antonio, Varcasia Antonio
Summary: Cardio-pulmonary parasites are prevalent in red foxes in Sardinia, with an overall prevalence rate of 54.9%. The most commonly found parasites are Eucoleus aerophilus, Crenosoma vulpis, and Angiostrongylus vasorum. The increased prevalence of these parasites suggests that red foxes in Sardinia serve as a reservoir host and should be considered in the diagnosis of respiratory distress syndrome in dogs.
PARASITOLOGY RESEARCH
(2023)
Correction
Parasitology
Francesca Nonnis, Claudia Tamponi, Gabriele Tosciri, Maria Manconi, Flavia Pudda, Pierangela Cabras, Giorgia Dessi, Antonio Scala, Antonio Varcasia
PARASITOLOGY RESEARCH
(2023)
Article
Neurosciences
Anna Castelnovo, Silvia Miano, Raffaele Ferri, Alberto Raggi, Michelangelo Maestri, Valentina Bottasini, Matteo Anelli, Marco Zucconi, Vincenza Castronovo, Luigi Ferini-Strambi, Mauro Manconi
Summary: The study aimed to evaluate the neuropsychological and neurophysiological profile of chronic insomniacs taking long-term high doses of benzodiazepine. The results showed that patients with chronic insomnia and benzodiazepine use disorder exhibited significant frontal lobe executive dysfunction, particularly in the cognitive flexibility domain, while their working memory, short-term memory, and long-term memory were relatively preserved. Compared to the control group, patients had a decrease in P300 amplitude, mainly in the frontal regions. Therefore, careful evaluation and management of long-term high-dose benzodiazepine intake should be considered for this specific patient population, especially regarding risky activities.
Article
Plant Sciences
Manuel Tiburtini, Gianluigi Bacchetta, Marco Sarigu, Salvatore Cambria, Paolo Caputo, Daniele De Luca, Gianniantonio Domina, Alessia Turini, Lorenzo Peruzzi
Summary: An integrative approach was used to resolve the complex taxonomy and systematics of the genus Armeria in Sardinia and Corsica. The study found that some taxa are no longer supported by new data, leading to a new taxonomic hypothesis that considers only five species endemic to the islands.
Article
Engineering, Civil
Ali Shahmirzaloo, Marco Manconi, Bart van den Hurk, Bowen Xu, Rijk Blok, Patrick Teuffel
Summary: This paper presents the numerical and experimental analysis of a large-scale footbridge model made of flax fiber-reinforced polyester composite. The study aims to support the design of a flax-polyester footbridge with a span of 15 meters. A composite laminate model was created using ABAQUS for numerical analysis, and 16 embedded fiber-optic Bragg grating sensors were used for strain sensing and mechanical evaluation. The results from the numerical analysis were in good agreement with the load test, validating the assumptions made.
ENGINEERING STRUCTURES
(2023)
Article
Biochemistry & Molecular Biology
Yara Salem, Hiba N. Rajha, Suhair Sunoqrot, Alaa M. Hammad, Ines Castangia, Maria Manconi, Maria Letizia Manca, Dana Al Lababidi, Joe A. Touma, Richard G. Maroun, Nicolas Louka
Summary: Exhausted grape seed residues can be transformed into promising cosmetic scrubs capable of releasing antioxidant molecules during exfoliation process, showing good physical stability and no irritation phenomena. This highlights the importance of effectively utilizing agro-industrial by-products for the development of sustainable and zero-waste cosmeceutics.
Article
Neurosciences
Anna Castelnovo, Althea Lividini, Brady A. Riedner, Giulia Avvenuti, Stephanie G. Jones, Silvia Miano, Giulio Tononi, Mauro Manconi, Giulio Bernardi
Summary: The study aimed to characterize the characteristics of individual slow waves, including origin, synchronization, and cortical propagation, between children and adults. The study found that slow waves in children were larger, steeper, and less widespread compared to adults, mainly originating from and spreading over more posterior brain areas. The slow waves of children also tended to involve and originate more from the right hemisphere compared to adults. The analysis of slow waves with high and low synchronization efficiency showed distinct maturation patterns, suggesting different generation and synchronization mechanisms.
Article
Agriculture, Multidisciplinary
Adriana dos Santos Ferreira, Caio Cesar Pereira Leal, Moadir de Sousa Leite, Clarisse Pereira Benedito, Alek Sandro Dutra, Charline Zaratin Alves, Elis Regina Costa de Morais, Marcio Dias Pereira, Marco Porceddu, Gianluigi Bacchetta, Salvador Barros Torres
Summary: The objective of this study was to evaluate the morphophysiological and biochemical changes in Enterolobium contortisiliquum seedlings subjected to water and salt stresses. The results showed that both salt and water stresses compromised the development of E. contortisiliquum seedlings, with the damage becoming more severe from an electrical conductivity of irrigation water of 2 dS m-1 and four days without irrigation. The survival mechanism of E. contortisiliquum to abiotic stresses involves reduction in growth and quality of seedlings, accompanied by the activation of biochemical defense mechanisms of the species.
REVISTA CIENCIA AGRONOMICA
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)