A novel series of benzothiazepine derivatives as tubulin polymerization inhibitors with anti-tumor potency

Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells

(2020) Stella Cascioferro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

(2020) Stella Cascioferro et al.   MOLECULES

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

(2020) Stella Cascioferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

MRI Types of Cerebral Small Vessel Disease and Circulating Markers of Vascular Wall Damage

(2020) Larisa A. Dobrynina et al.   Diagnostics

Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors

(2020) Fang Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung Cancer

(2019) Ayesha Murtuza et al.   CANCER RESEARCH

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

(2019) Conghui Liu et al.   ACS Nano

Single and dual targeting of mutant EGFR with an allosteric inhibitor

(2019) Ciric To et al.   Cancer Discovery

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities

(2019) Fang Yang et al.   BIOORGANIC CHEMISTRY

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors

(2016) Yu-Shun Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells

(2016) Anna Klimaszewska-Wisniewska et al.   Cancer Cell International

Mitotic catastrophe and cancer drug resistance: A link that must to be broken

(2016) Tatiana V. Denisenko et al.   DRUG RESISTANCE UPDATES

Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin

(2016) Pengfei Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

(2016) María-Jesús Pérez-Pérez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization

(2016) Christine A. Herdman et al.   MedChemComm

Colchicine: Old and New

(2015) Anastasia Slobodnick et al.   AMERICAN JOURNAL OF MEDICINE

Tubulin Colchicine Binding Site Inhibitors as Vascular Disrupting Agents in Clinical Developments

(2015) Ya-Ting Ji et al.   CURRENT MEDICINAL CHEMISTRY

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

(2015) Yuxi Wang et al.   FEBS Journal

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

Recent developments in tubulin polymerization inhibitors: An overview

(2014) Ramandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents

(2014) Shilong Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

(2014) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

How Taxol/paclitaxel kills cancer cells

(2014) Beth A. Weaver   MOLECULAR BIOLOGY OF THE CELL

Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe

(2014) M Cornago et al.   Cell Death & Disease

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted iso combretastatin A-4 analogs

(2013) Evelia Rasolofonjatovo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

cis-Restricted 3-Aminopyrazole Analogues of Combretastatins: Synthesis from Plant Polyalkoxybenzenes and Biological Evaluation in the Cytotoxicity and Phenotypic Sea Urchin Embryo Assays

(2013) Dmitry V. Tsyganov et al.   JOURNAL OF NATURAL PRODUCTS

Design, synthesis, biological evaluation and molecular modeling of novel 1,3,4-oxadiazole derivatives based on Vanillic acid as potential immunosuppressive agents

(2012) Jian-Feng Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Microtubule catastrophe and rescue

(2012) Melissa K Gardner et al.   CURRENT OPINION IN CELL BIOLOGY

Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance

(2010) Aleem Gangjee et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Akt expression correlates with the VEGF-A and -C expression as well as the microvessel and lymphatic vessel density in breast cancer

(2010) Tsutsui   ONCOLOGY REPORTS

AVE8062: a new combretastatin derivative vascular disrupting agent

(2009) Angelo Delmonte et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS