Article
Sport Sciences
Heath M. Burton, Edward F. Coyle
Summary: Reducing daily step counts to approximately 2500-5000 steps per day impairs the acute exercise-induced increase in fat oxidation and attenuation of postprandial plasma triglyceride increases in young healthy individuals. Exercise resistance seems to occur in individuals taking approximately 5000 or fewer steps per day, while 8500 steps per day protect against exercise resistance in fat metabolism. Fat metabolism appears to be more influenced by the inhibitory effects of inactivity than by the stimulating effects derived from 1 h of moderate-intensity running.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Pediatrics
Shwetha Kuthiroly, Dhanya Yesodharan, Natasha Radhakrishnan, Aparna Ganapathy, Ashraf U. Mannan, Michael M. Hoffmann, Sheela Nampoothiri
Summary: This study analyzed the clinical and molecular spectrum of Lipoprotein Lipase deficiency, highlighting the importance of a strict low-fat diet in managing the disorder effectively.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Food Science & Technology
Hong Xu, Hang Gao, Feiyue Liu, Lingxiao Gong
Summary: This study found that red-skin extracts from lotus seeds can significantly improve obesity characteristics in high-fat-diet-fed mice by regulating lipoprotein lipase activity.
Review
Nutrition & Dietetics
Emilia Vassilopoulou, George Guibas, Nikolaos G. Papadopoulos
Summary: The second wave of the allergy epidemic is currently affecting both affluent societies and developing countries. Changes in lifestyle and diet, including the consumption of processed foods, may contribute to the increase in prevalence of atopy/asthma. The Mediterranean diet has been studied as a potential protective factor against asthma/atopy, but the evidence is inconclusive.
Article
Food Science & Technology
Eline Van Wayenbergh, Niels A. Langenaeken, Nore Struyf, Peter Goos, Imogen Foubert, Christophe M. Courtin
Summary: Food fortification is an effective strategy against vitamin A deficiency, and cereal bran can be used as a natural stabilising agent. The stabilising effect of wheat bran on vitamin A is stronger for samples with high antioxidant capacity, high bound lipid content, and low lipase activity. Wheat bran antioxidants and bound lipids protect vitamin A from degradation during storage, while endogenous lipase activity counteracts the stabilising effect.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Clinical Neurology
Haiting Xu, Rongrong Li, Leilei Wang, Tingting Wang, Yanhong Luo, Yanyan Wei, Jingxu Chen
Summary: Recent studies have shown that oxidative stress is involved in the development of BD. This study used clinical data to investigate the levels of non-enzymatic anti-oxidants, macro-minerals, and MHR in BD and healthy controls, as well as the differences between psychotic and non-psychotic BD. The results showed that there were differences in these parameters among the different groups, and certain parameters were associated with the occurrence of BD and psychotic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Nutrition & Dietetics
Liali Aljouda, Laura Nagy, Andreas Schulze
Summary: This study investigated the effectiveness of a diet restricted in long-chain triglycerides (LCTs) and supplemented with medium-chain triglycerides (MCTs) in reducing triglyceride levels and symptoms in children with lipoprotein lipase (LPL) deficiency. Results showed that the diet led to a significant drop in triglyceride levels in LPL patients and no disease-specific manifestations or complications. The study suggests that the LCT-restricted and MCT-supplemented diet is a feasible, well-tolerated, and clinically effective long-term management option for pediatric patients with LPL deficiency.
Review
Biochemistry & Molecular Biology
Nicole M. DiDonna, Yan Q. Chen, Robert J. Konrad
Summary: This review summarizes the recent research progress on the role of angiopoietin-like (ANGPTL) proteins in fatty acid metabolism. Recent studies have found that the ANGPTL3/4/8 proteins regulate fatty acid partitioning in a tissue-specific manner by forming complexes with ANGPTL8. These proteins play critical roles in postprandial fatty acid distribution and hold promise for targeted treatment of metabolic disorders.
CURRENT OPINION IN LIPIDOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liyan Yu, Hongguang Liu, Xiaoxia Ma, Vidya Devanathadesikan Seshadri, Xuan Gao
Summary: The study found that Myrtenal has anti-atherosclerotic activity in high-fat diet-induced atherosclerosis rat models. Myrtenal-treated groups showed the ability to modulate the lipid metabolic pathway, reducing blood lipid levels and inflammatory cytokines.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Albert Sanllorente, Camille Lassale, Maria Trinidad Soria-Florido, Olga Castaner, Montserrat Fito, Alvaro Hernaez
Summary: This systematic review summarized studies on high-density lipoprotein (HDL) functionality, showing that lifestyle interventions such as dietary modifications, antioxidants, and physical activity can improve HDL lipid function, particularly benefiting individuals with cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sujith Rajan, Hazel C. de Guzman, Thomas Palaia, Ira J. Goldberg, M. Mahmood Hussain
Summary: This new fluorescence method allows real-time measurement of lipase activity without the need to separate substrates from products. It is used to assess four major TAG hydrolases, including pancreatic lipase and hormone-sensitive lipase, by measuring enzyme activities based on the reaction of lipase sources with substrate vesicles containing NBD-TAG. This assay is potentially applicable to a wide range of lipases and can be used for high-throughput screening and diagnostic purposes.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Nutrition & Dietetics
Xuan Li, Hiroaki Yamada, Sayo Morita, Yusuke Yamashita, Youngil Kim, Takashi Kometani, Nikesh Narang, Toma Furuta, Mujo Kim
Summary: A study found that the ethanolic extract of sesame meal is a potent pancreatic lipase inhibitor, and it can significantly reduce postprandial triglyceride concentration and improve lipidemic profile. In a crossover trial, treatment with the sesame meal extract showed significant improvement in postprandial blood indicators after high dietary fat intake in healthy individuals. This suggests the significant potential of free linoleic acid and oleic acid and natural products rich in these compounds for managing obesity and related conditions.
Article
Neurosciences
Celine Cansell, Katharina Stobbe, Clara Sanchez, Ophelia Le Thuc, Coralie-Anne Mosser, Selma Ben-Fradj, Joris Leredde, Cynthia Lebeaupin, Delphine Debayle, Lucile Fleuriot, Frederic Brau, Nadege Devaux, Alexandre Benani, Etienne Audinat, Nicolas Blondeau, Jean-Louis Nahon, Carole Rovere
Summary: Obesity in humans is associated with brain inflammation, glial reactivity, and immune cell infiltration. Studies in rodents have shown that glial reactivity occurs shortly after consuming a high-fat diet, even before obesity develops, primarily in the hypothalamus. This postprandial inflammation in the brain may contribute to the development of obesity and requires further characterization.
Article
Pharmacology & Pharmacy
Evangelia Tzeravini, Anastasios Tentolouris, Ioanna Eleftheriadou, Nikolaos Chaviaras, Genovefa Kolovou, Fani Apostolidou-Kiouti, Eleftherios Stratigakos, Nikolaos Tentolouris
Summary: The study showed that serum triglyceride levels were higher during the follicular compared with the luteal phase in women after a standardized fat tolerance test, but the overall postprandial triglyceride response did not differ significantly between the two phases. Postprandial ApoB and non-HDL-C serum concentrations were not affected by the menstrual cycle.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryan G. Snodgrass, Marcel Boss, Ekaterina Zezina, Andreas Weigert, Nathalie Dehne, Ingrid Fleming, Bernhard Bruene, Dmitry Namgaladze
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Ricardo Capelo, Christoph Lehmann, Khalil Ahmad, Ryan Snodgrass, Olaf Diehl, Julia Ringleb, Nicolas Flamand, Andreas Weigert, Holger Stark, Dieter Steinhilber, Astrid S. Kahnt
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Ekaterina Zezina, Ryan G. Snodgrass, Yannick Schreiber, Sven Zukunft, Christoph Schuermann, Dagmar Meyer zu Heringdorf, Gerd Geisslinger, Ingrid Fleming, Ralf P. Brandes, Bernhard Bruene, Dmitry Namgaladze
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2018)
Review
Oncology
Andreas Weigert, Elisabeth Strack, Ryan G. Snodgrass, Bernhard Bruene
CANCER AND METASTASIS REVIEWS
(2018)
Article
Immunology
Ryan G. Snodgrass, Ekaterina Zezina, Dmitry Namgaladze, Sahil Gupta, Carlo Angioni, Gerd Geisslinger, Dieter Luetjohann, Bernhard Bruene
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Sahil Gupta, Arpit Jain, Shahzad Nawaz Syed, Ryan G. Snodgrass, Beatrice Pflueger-Mueller, Matthias S. Leisegang, Andreas Weigert, Ralf P. Brandes, Ingo Ebersberger, Bernhard Bruene, Dmitry Namgaladze
Review
Pharmacology & Pharmacy
Ryan G. Snodgrass, Bernhard Bruene
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Immunology
Alexander Queck, Annika F. Fink, Evelyn Sirait-Fischer, Sabrina Ruschenbaum, Dominique Thomas, Ryan G. Snodgrass, Gerd Geisslinger, Hideo A. Baba, Jonel Trebicka, Stefan Zeuzem, Andreas Weigert, Christian M. Lange, Bernhard Bruene
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biology
Anna S. Frank, Kamila Larripa, Hwayeon Ryu, Ryan G. Snodgrass, Susanna Roeblitz
Summary: This paper presents and analyzes a mathematical model for the polarization of a single macrophage, demonstrating that asymmetry in regulatory mechanisms and parameter values is important for observing multiple phenotypes. Bifurcation and sensitivity analyses show the necessity of external signaling cues and importance of intrinsic macrophage pathways for macrophage commitment and emergence to a phenotype. The numerical results formulate hypotheses for further investigation through laboratory experiments to deepen the understanding of macrophage polarization.
JOURNAL OF THEORETICAL BIOLOGY
(2021)
Article
Immunology
Ana Carolina Mota, Monica Dominguez, Andreas Weigert, Ryan G. Snodgrass, Dmitry Namgaladze, Bernhard Bruene
Summary: Efferocytosis is crucial for maintaining tissue homeostasis and involves activation of transcription factors such as PPAR and LXR. This study explored the transcriptional profile of macrophages following uptake of apoptotic cells, showing upregulation of PPAR and LXR pathways. The activation mechanisms of PPAR and LXR in efferocytotic human macrophages were elucidated, providing insights into their roles in metabolic and inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen
Summary: Age-related changes in monocyte frequencies and subsets are observed, and consuming a fat-containing meal induces temporal changes in monocyte frequency and subsets, independent of age.
Article
Immunology
Helene Sertznig, Fabian Roesmann, Alexander Wilhelm, Delia Heininger, Barbara Bleekmann, Carina Elsner, Mario Santiago, Jonas Schuhenn, Zehra Karakoese, Yvonne Benatzy, Ryan Snodgrass, Stefan Esser, Kathrin Sutter, Ulf Dittmer, Marek Widera
Summary: This study shows that HIV-1 infection is associated with low levels of SRSF1 in intestinal and peripheral blood mononuclear cells. The repression of SRSF1 leads to increased viral RNA levels, but reduced levels of the Vif coding transcripts. However, in the presence of high levels of APOBEC3G, the decrease in SRSF1 enhances overall replication.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Ryan G. Snodgrass, Xiaowen Jiang, Charles B. Stephensen, Kevin D. Laugero
Summary: The study examined the relationship between cumulative physiological stress and lymphocyte changes associated with aging. The results showed that physiological stress load increased with age and was negatively correlated with the frequency of regulatory T lymphocytes. The findings suggest that physiological stress load may affect the frequencies of Treg cells in younger individuals, leading to levels similar to those seen in older adults.
Article
Biochemistry & Molecular Biology
Ryan G. Snodgrass, Yvonne Benatzy, Tobias Schmid, Dmitry Namgaladze, Malwina Mainka, Nils Helge Schebb, Dieter Luetjohann, Bernhard Bruene
Summary: The study identified a mechanism whereby macrophages selectively upregulate anti-inflammatory and proresolving genes when exposed to apoptotic cells or LXR agonists and Th2 cytokines, enhancing inflammation resolution and tissue repair.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Immunology
Kikumi D. Ono-Moore, Ling Zhao, Shurong Huang, Jeonga Kim, Jennifer M. Rutkowsky, Ryan G. Snodgrass, Dina A. Schneider, Michael J. Quon, James L. Graham, Peter J. Havel, Daniel H. Hwang
IMMUNITY INFLAMMATION AND DISEASE
(2017)