Article
Psychiatry
Farhana Islam, Leen Magarbeh, Samar S. M. Elsheikh, Stefan Kloiber, Caroline W. Espinola, Venkat Bhat, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Treatment-emergent sexual dysfunction is a common issue in individuals with major depressive disorder on antidepressants. This study found that polymorphisms in genes encoding drug-metabolizing enzymes and the transmembrane efflux pump were associated with changes in sexual function and satisfaction. Specifically, CYP2C19 metabolizer phenotypes were linked to changes in sexual arousal, and higher concentrations of the escitalopram metabolite, S-desmethylcitalopram, were associated with a decline in sexual function and satisfaction in females.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Calvin Diep, Norma Rosenek, Yuelee Khoo, Wiebke Gandhi, Carien M. van Reekum, Arun V. Ravindran, Karim S. Ladha, Benicio N. Frey, Roumen V. Milev, Susan Rotzinger, Raymond W. Lam, Sidney H. Kennedy, Wendy Lou, Tim Salomons, Venkat Bhat
Summary: This study investigated the pain-alleviating effects of escitalopram and adjunctive aripiprazole for patients with comorbid pain and depression. The results showed significant improvements in pain severity and interference for patients receiving escitalopram, regardless of treatment response. However, patients receiving aripiprazole after week 8 did not experience further improvement in pain symptoms. Further research is needed to identify interventions that can effectively treat both pain and depression symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Emma Morton, Venkat Bhat, Peter Giacobbe, Wendy Lou, Erin E. Michalak, Shane McInerney, Trisha Chakrabarty, Benicio N. Frey, Roumen V. Milev, Daniel J. Muller, Sagar V. Parikh, Susan Rotzinger, Sidney H. Kennedy, Raymond W. Lam
Summary: The study aimed to explore predictors of domain-specific quality of life improvement following adjunctive aripiprazole treatment for inadequate response to initial antidepressant therapy among MDD patients. Results showed that QoL improved across domains with adjunctive aripiprazole treatment, along with improvements in functioning and satisfaction with medication. Symptom reduction and functioning improvements were predictive of positive change in QoL domains, with satisfaction with medication also being a significant predictor.
Article
Clinical Neurology
Trisha Chakrabarty, Shane J. McInerney, Ivan J. Torres, Benicio N. Frey, Roumen V. Milev, Daniel J. Muller, Susan Rotzinger, Sidney H. Kennedy, Raymond W. Lam
Summary: This study aimed to examine the cognitive changes in patients with major depressive disorder (MDD) after receiving different treatment approaches. The results showed that escitalopram monotherapy in acute MDD did not lead to significant cognitive improvements, while continuation of escitalopram in responders did not adversely affect cognition. However, adjunctive aripiprazole in escitalopram non-responders was associated with worsened reaction time. Treatments targeting cognitive dysfunction are needed in MDD.
Article
Pharmacology & Pharmacy
Emma Morton, Venkat Bhat, Peter Giacobbe, Wendy Lou, Erin E. Michalak, Trisha Chakrabarty, Benicio N. Frey, Roumen V. Milev, Daniel J. Muller, Sagar V. Parikh, Susan Rotzinger, Sidney H. Kennedy, Raymond W. Lam
Summary: For individuals with major depressive disorder (MDD), those who did not respond to initial antidepressant treatment showed significant improvements in quality of life (QoL) after receiving adjunctive aripiprazole for 8 weeks following 8 weeks of escitalopram treatment. Additionally, even after achieving symptomatic remission, a substantial number of patients still experienced impaired QoL. Thus, attention to supporting QoL outcomes is critical as QoL deficits may predict MDD recurrence.
PHARMACOPSYCHIATRY
(2021)
Article
Clinical Neurology
Yuelee Khoo, Ilya Demchenko, Benicio N. Frey, Roumen Milev, Arun Ravindran, Sagar Parikh, Keith Ho, Susan Rotzinger, Wendy Lou, Raymond W. Lam, Sidney H. Kennedy, Venkat Bhat
Summary: Early improvement in anxiety and depression during the first two weeks of treatment significantly predicts the eventual treatment outcomes for anxiety and depression. Baseline anxiety severity is a strong predictor of anxiety outcomes at weeks 2 and 8. The study suggests that focusing on early improvement in anxiety may be more beneficial in predicting treatment outcomes for anxiety depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Mehri Sajjadian, Rudolf Uher, Keith Ho, Stefanie Hassel, Roumen Milev, Benicio N. Frey, Faranak Farzan, Pierre Blier, Jane A. Foster, Sagar Parikh, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Gustavo Turecki, Valerie H. Taylor, Raymond W. Lam, Stephen C. Strother, Sidney H. Kennedy
Summary: Predicting treatment outcomes for major depressive disorder can be improved by combining clinical, neuroimaging, and molecular data. Early measurement during treatment can increase precision, but adding more features does not necessarily enhance prediction accuracy.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Esra Kutlu, Ilker Tolga Ozgen, Huri Bulut, Abdurrahim Kocyigit, Hafize Otcu, Yasar Cesur
Summary: This study found that irisin levels were higher in patients with central precocious puberty compared to other groups, and irisin levels were positively correlated with several clinical and laboratory parameters. Peak LH was identified as the strongest independent predictive factor of irisin levels, followed by BMI-SDS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Valur Emilsson, Valborg Gudmundsdottir, Alexander Gudjonsson, Thorarinn Jonmundsson, Brynjolfur G. Jonsson, Mohd A. Karim, Marjan Ilkov, James R. Staley, Elias F. Gudmundsson, Lenore J. Launer, Jan H. Lindeman, Nicholas M. Morton, Thor Aspelund, John R. Lamb, Lori L. Jennings, Vilmundur Gudnason
Summary: There is a genetic overlap between circulating proteins and a wide range of common diseases. These findings highlight the emerging role of serum proteins as biomarkers and potential causative agents of diseases.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Shelley Jager, Dario A. T. Cramer, Albert J. R. Heck
Summary: Alpha-1-antitrypsin (A1AT) has been suggested as a potential biomarker for distinguishing healthy and diseased individuals. However, the variability of the SERPINA1 gene in the general population may affect A1AT expression and serum protein levels, which are often overlooked in proteomics studies. This study found significant differences in allele-specific protein serum levels of A1AT among heterozygous donors, suggesting the importance of considering these factors when analyzing A1AT as a potential serum biomarker.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biology
Kriste Kaikaryte, Greta Gedvilaite, Alvita Vilkeviciute, Loresa Kriauciuniene, Ruta Mockute, Dzastina Cebatoriene, Reda Zemaitiene, Vilma Jurate Balciuniene, Rasa Liutkeviciene
Summary: This study found that SIRT1 gene polymorphisms are associated with the development of AMD, and certain genotypes are associated with elevated serum SIRT1 levels.
Article
Medicine, General & Internal
Tingting Sha, Yilun Wang, Yuqing Zhang, Nancy E. Lane, Changjun Li, Jie Wei, Chao Zeng, Guanghua Lei
Summary: A genetic association study found a nonlinear association between suboptimal vitamin D levels and the risk of sarcopenia. Further randomized clinical trials are needed to confirm the potential causality.
Article
Immunology
Maria del Carmen Maza, Maria Ubeda, Pilar Delgado, Lydia Horndler, Miguel A. Llamas, Hisse M. van Santen, Balbino Alarcon, David Abia, Laura Garcia-Bermejo, Sergio Serrano-Villar, Ugo Bastolla, Manuel Fresno
Summary: This study found that highly exposed but uninfected individuals have significantly higher levels of ACE2 in their serum. Furthermore, the serum from these seronegative individuals can effectively neutralize SARS-CoV-2 infection, suggesting that high levels of ACE2 may provide some protection against active infection without generating a conventional antibody response. Additionally, the study also revealed that ACE2 levels were higher in infected patients who developed cutaneous symptoms compared to respiratory symptoms, and ACE2 levels were higher in patients with milder symptoms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Owen Hicks, Shane J. McInerney, Raymond W. Lam, Roumen V. Milev, Benicio N. Frey, Claudio N. Soares, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Kate L. Harkness
Summary: This study found that exposure to minor life events has a positive impact on symptom improvement in patients with MDD, but only for those experiencing higher levels of chronic stress. However, during the follow-up period, major life events predicted an increased risk of relapse, independent of chronic stress. Therefore, additional strategies may be needed to enhance outcomes during pharmacotherapy and prevent relapse.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neuroimaging
Jacqueline K. Harris, Stefanie Hassel, Andrew D. Davis, Mojdeh Zamyadi, Stephen R. Arnott, Roumen Milev, Raymond W. Lam, Benicio N. Frey, Geoffrey B. Hall, Daniel J. Muller, Susan Rotzinger, Sidney H. Kennedy, Stephen C. Strother, Glenda M. MacQueen, Russell Greiner
Summary: Previous intervention studies have used fMRI data to predict the antidepressant response of patients with MDD. However, the limited scope of these studies may not accurately reflect real-world situations. This study suggests that collecting fMRI data before and shortly after treatment initiation can lead to improved predictive models.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Prabhjot Dhami, Lena C. Quilty, Benjamin Schwartzmann, Rudolf Uher, Timothy A. Allen, Stefan Kloiber, Raymond W. Lam, Glenda MacQueen, Benicio N. Frey, Roumen Milev, Daniel J. Mueller, Stephen C. Strother, Pierre Blier, Claudio N. Soares, Sagar V. Parikh, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Faranak Farzan
Summary: The neurobiological correlates of response inhibition can predict the response of patients with major depressive disorder (MDD) to pharmacological and cognitive behavioral therapy treatment. The integrity of response inhibition may be crucial for the success of treatment for MDD. Electrophysiological correlates of response inhibition may serve as a general prognostic marker for treatment response in MDD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Review
Psychiatry
Smadar V. Tourjman, Gabriella Buck, Didier Jutras-Aswad, Atul Khullar, Shane McInerney, Gayatri Saraf, Jairo V. Pinto, Stephane Potvin, Marie-Josee Poulin, Benicio N. Frey, Sidney H. Kennedy, Raymond W. Lam, Glenda MacQueen, Roumen Milev, Sagar V. Parikh, Arun Ravindran, Roger S. McIntyre, Ayal Schaffer, Valerie H. Taylor, Michael van Ameringen, Lakshmi N. Yatham, Serge Beaulieu
Summary: This task force report examines the association between cannabis use and bipolar disorder, major depressive disorder, and comorbid cannabis use disorder. The results indicate that cannabis use is associated with worsened course and functioning of both mood disorders, particularly in bipolar disorder. However, the treatment of comorbid cannabis use disorder and major depressive disorder did not show significant results.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Psychiatry
Joshua D. Rosenblat, M. Ishrat Husain, Yena Lee, Roger S. McIntyre, Rodrigo B. Mansur, David Castle, Hilary Offman, Sagar Parikh, Benicio N. Frey, Ayal Schaffer, Kyle T. Greenwaym, Nicolas Garel, Serge Beaulieu, Sidney H. Kennedy, Raymond W. Lam, Roumen Milev, Arun Ravindran, Valerie Tourjman, Michael Van Ameringen, Lakshmi N. Yatham, Valerie Taylor
Summary: There is currently only low-level evidence to support the efficacy and safety of psychedelics for major depressive disorder.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychology, Clinical
Mehri Sajjadian, Rudolf Uher, Keith Ho, Stefanie Hassel, Roumen Milev, Benicio N. Frey, Faranak Farzan, Pierre Blier, Jane A. Foster, Sagar Parikh, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Gustavo Turecki, Valerie H. Taylor, Raymond W. Lam, Stephen C. Strother, Sidney H. Kennedy
Summary: Predicting treatment outcomes for major depressive disorder can be improved by combining clinical, neuroimaging, and molecular data. Early measurement during treatment can increase precision, but adding more features does not necessarily enhance prediction accuracy.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Katerina Dikaios, Sheri Rempel, Sri Harsha Dumpala, Sageev Oore, Michael Kiefte, Rudolf Uher
Summary: The need for objective measurement in psychiatry has led to research on using speech analysis as an alternative indicator of mental disorders. The findings suggest that speech features can accurately classify and assess the severity of psychiatric illnesses, predict onset, and determine prognosis and treatment outcomes. However, differentiating between types of mental disorders and symptom dimensions remains a challenge.
HARVARD REVIEW OF PSYCHIATRY
(2023)
Article
Psychiatry
Alyson Zwicker, Janice M. Fullerton, Niamh Mullins, Frances Rice, Danella M. Hafeman, Neeltje E. M. van Haren, Nikita Setiaman, John A. Merranko, Benjamin I. Goldstein, Alessandra G. Ferrera, Emma K. Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergio Mas Herrero, Gloria Roberts, Claudio Toma, Peter R. Schofield, Howard J. Edenberg, Holly C. Wilcox, Melvin G. McInnis, Victoria Powell, Lukas Propper, Eileen Denovan-Wright, Guy Rouleau, Josefina Castro-Fornieles, Manon H. J. Hillegers, Boris Birmaher, Anita Thapar, Philip B. Mitchell, Cathryn M. Lewis, Martin Alda, John I. Nurnberger, Rudolf Uher
Summary: The authors found that polygenic scores (PGSs) can complement family history to improve identification of risk for major mood and psychotic disorders. PGSs for neuroticism and subjective well-being are significantly associated with the onsets of disorders, and PGSs for psychiatric illness have limited predictive power when family history is known.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Kate L. Harkness, Trisha Chakrabarty, Sakina J. Rizvi, Raegan Mazurka, Lena Quilty, Rudolf Uher, Roumen V. Milev, Benicio N. Frey, Sagar V. Parikh, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Raymond W. Lam
Summary: This study aims to investigate the differential associations of different types of childhood maltreatment with the response to antidepressant medication, and the role of anhedonia in driving poor response in patients with specific maltreatment histories. The results suggest that the severity of emotional maltreatment perpetrated by the mother is a significant predictor of lower odds of remission at week 16. In contrast, the relationships between paternal-perpetrated emotional maltreatment and physical maltreatment with week 16 remission were mediated through the severity of anhedonia at week 8.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Anthony L. Vaccarino, Sandra E. Black, Susan Gilbert Evans, Benicio N. Frey, Mojib Javadi, Sidney H. Kennedy, Benjamin Lam, Raymond W. Lam, Bianca Lasalandra, Emily Martens, Mario Masellis, Roumen Milev, Sara Mitchell, Douglas P. Munoz, Alana Sparks, Richard H. Swartz, Brian Tan, Rudolf Uher, Kenneth R. Evans
Summary: The study used Rasch Measurement Theory to evaluate the measurement properties of the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) in neurodegenerative disorders (ND) and major depressive disorder (MDD). The results showed that the QIDS-SR is suitable for assessing and screening depressive symptoms in persons with ND, but there are limitations in differentiating participants at certain severity levels.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Farhana Islam, Leen Magarbeh, Samar S. M. Elsheikh, Stefan Kloiber, Caroline W. Espinola, Venkat Bhat, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Treatment-emergent sexual dysfunction is a common issue in individuals with major depressive disorder on antidepressants. This study found that polymorphisms in genes encoding drug-metabolizing enzymes and the transmembrane efflux pump were associated with changes in sexual function and satisfaction. Specifically, CYP2C19 metabolizer phenotypes were linked to changes in sexual arousal, and higher concentrations of the escitalopram metabolite, S-desmethylcitalopram, were associated with a decline in sexual function and satisfaction in females.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
John-Jose Nunez, Yang S. Liu, Bo Cao, Benicio N. Frey, Keith Ho, Roumen Milev, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Valerie H. Taylor, Rudolf Uher, Sidney H. Kennedy, Raymond W. Lam
Summary: Depression is a complex disorder with a heterogeneous response to treatment. This study used machine learning to cluster patients with depression and found three distinct response patterns. The subjective mood state/anhedonia was identified as the core feature of response to escitalopram, but there were also other patterns related to neurovegetative symptoms, activation, and cognition.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Rudolf Uher, Barbara Pavlova, Joaquim Radua, Umberto Provenzani, Sara Najafi, Lydia Fortea, Maria Ortuno, Anna Nazarova, Nader Perroud, Lena Palaniyappan, Katharina Domschke, Samuele Cortese, Paul D. Arnold, Jehannine C. Austin, Michael M. Vanyukov, Myrna M. Weissman, Allan H. Young, Manon H. J. Hillegers, Andrea Danese, Merete Nordentoft, Robin M. Murray, Paolo Fusar-Poli
Summary: The offspring of parents with mental disorders have an increased risk of developing mental disorders themselves, extending beyond the specific disorders present in their parents. This comprehensive meta-analysis provides important insights for targeted prevention and genetic counseling.
Editorial Material
Psychiatry
Simone Battaglia, Andre Schmidt, Stefanie Hassel, Masaru Tanaka
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Katerina Rnic, Joelle Lemoult, Ivan J. Torres, Trisha Chakrabarty, Jane Foster, Benicio N. Frey, Kate L. Harkness, Keith Ho, Qingqin S. Li, Roumen Milev, Lena C. Quilty, Susan Rotzinger, Claudio N. Soares, Rudolf Uher, Sidney H. Kennedy, Raymond W. Lam
Summary: Implicit self-depressed associations (SDAs) may serve as a cognitive biomarker for predicting depression recurrence, as higher baseline SDAs and increasing SDAs over time were found to be associated with shorter time to MDD recurrence among treatment responders.
PSYCHIATRY RESEARCH
(2023)