Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells
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Title
Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells
Authors
Keywords
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Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-11-28
DOI
10.1007/s00262-022-03335-w
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- Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer
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- (2021) Enli Liu et al. Frontiers in Immunology
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- (2021) Dominique L. Birrer et al. ANNALS OF SURGERY
- Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy
- (2021) Noam Levin et al. CLINICAL CANCER RESEARCH
- Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
- (2021) Justina X. Caushi et al. NATURE
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- (2021) Adham S. Bear et al. Nature Communications
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- The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients
- (2020) Zuzana Strizova et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
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- (2020) Yan Yang et al. Molecular Therapy-Methods & Clinical Development
- 4‐1BB costimulation promotes bystander activation of human CD8 T cells
- (2020) Manuel Reithofer et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Broadening the impact of immunotherapy to pancreatic cancer: Challenges and opportunities
- (2019) Vinod P. Balachandran et al. GASTROENTEROLOGY
- Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
- (2019) Gal Cafri et al. Nature Communications
- CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15– and IL-21–Driven NK Cell Proliferation
- (2019) Laurent Vidard et al. JOURNAL OF IMMUNOLOGY
- Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
- (2019) Maria R. Parkhurst et al. Cancer Discovery
- Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells
- (2019) Evelyn O. Ojo et al. Scientific Reports
- Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
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- Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
- (2018) Thomas Duhen et al. Nature Communications
- Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers
- (2018) Wouter Scheper et al. NATURE MEDICINE
- FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer
- (2018) Thierry Conroy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes
- (2018) Andrew McGuigan et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity
- (2017) E Liu et al. LEUKEMIA
- Tumor-infiltrating lymphocytes (TILs) from patients with glioma
- (2017) Zhenjiang Liu et al. OncoImmunology
- Expansion of Tumor-reactive T Cells From Patients With Pancreatic Cancer
- (2016) Qingda Meng et al. JOURNAL OF IMMUNOTHERAPY
- Drugging the Undruggable Ras — Immunotherapy to the Rescue?
- (2016) Carl H. June NEW ENGLAND JOURNAL OF MEDICINE
- T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
- (2016) Eric Tran et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immunogenicity of somatic mutations in human gastrointestinal cancers
- (2015) E. Tran et al. SCIENCE
- Activation and Propagation of Tumor-infiltrating Lymphocytes on Clinical-grade Designer Artificial Antigen-presenting Cells for Adoptive Immunotherapy of Melanoma
- (2014) Marie-Andrée Forget et al. JOURNAL OF IMMUNOTHERAPY
- IL-21 promotes the expansion of CD27+CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells
- (2013) Saskia JAM Santegoets et al. Journal of Translational Medicine
- Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy
- (2013) Jessica Ann Chacon et al. PLoS One
- Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity
- (2013) Nina Shah et al. PLoS One
- Membrane-bound interleukin-21 and CD137 ligand induce functional human natural killer cells from peripheral blood mononuclear cells through STAT-3 activation
- (2012) X. Wang et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
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- Tumor Infiltrating Lymphocyte Therapy for Metastatic Melanoma: Analysis of Tumors Resected for TIL
- (2010) Stephanie L. Goff et al. JOURNAL OF IMMUNOTHERAPY
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